Sentences with phrase «increased tumor cell proliferation»

Dr. Gollnick's laboratory explores how tumor cells co-opt the host immune system to promote chronic inflammation that leads to increased vascularization, suppression of anti-tumor immunity and increased tumor cell proliferation and migration.

Hyaluronidase Hyal1 increases tumor cell proliferation and motility through accelerated vesicle trafficking.

Not exact matches

«One of the major and immediate downstream effects of myc activation is a dramatic increase in the capacity of affected cells to make protein,» Ruggero said «This, in turn, leads to increased cell survival and proliferation, and to unstable genomes that foster additional mutations that turn these abnormal cells into tumor cells.»

They found higher levels of JAK1 in resistant tumors, which caused increased expression of epidermal growth factor receptor (EGFR)-- a receptor tyrosine kinase that promotes cell proliferation.

In the laboratory they showed how morphine can increase proliferation, migration and invasion of tumor cells.

However, an overactive stimulation of mTOR in response to nutrients and growth factors — metabolic processes that are crucial in tumor biology — leads to an increase in cell growth and proliferation.

In a first set of experiments, postdoctoral researcher and co-lead author Max - Felix Häring found that insulin increased the proliferation of mouse epithelial tumor cells in culture, as expected.

Increased transforming growth factor beta expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells.

Deletion of DGKζ from T cells results in prolonged TCR signal transduction downstream of DAG, resulting in enhanced activation of Ras, increased effector T cell proliferation, and amplified cytokine production, which leads to increased antitumor activity against s.c. implanted EL4 tumors or murine mesothelioma (12, 16, 17).

Yet its contribution to tumor cell proliferation only increases the evidence that changes in metabolism are a cause of cancer and not just a consequence, according to Leif Ellisen, a cancer genetics researcher and oncologist who directs the MGH Translational Research Laboratory.

They also show how this interaction can increase proliferation, migration and invasion of tumor cells, three hallmarks of cancer growth and spread.

Possible modes of hierarchy alteration are suggested as increased self - renewal (a), dedifferentiation of early progenitor cells (b), and blocked proliferation (c) of ER - α — positive and negative tumors.

Tumor hypoxia is often linked to decreased survival in patients with breast cancer and has been shown to induce specific molecular changes in cells including changes that confer a more malignant phenotype such as increased proliferation (3), survival (4), invasion (5), and metastasis (6).

This disease - fighting nutrient can slow the growth and development of new blood vessels that nourish tumors, increase a type of programmed cancer cell death known as apoptosis and reduce the proliferation of new cancer cells.