Sentences with phrase «increased tumorigenesis»

Not exact matches

All this work supports the conclusion that the over-expression of PREX2 can increase PI3K - dependent tumor growth (Fine et al., 2009), and that mutated PREX2 promotes tumorigenesis by increasing RAC - dependent invasiveness (Mense et al., 2015).

The pancreas seems to require two oncogenic events to initiate and promote tumorigenesis with tumor suppressors acting later to increase progression to malignant disease.

On the basis of this, we have hypothesized that p21 - deficient mice should not have an increased susceptibility to radiation - induced tumorigenesis.