Sentences with phrase «increases as the tumor»

Not exact matches

However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related lung cancers.

Instead, Schlom says, «what we're seeing is increases in patient survival, as opposed to tumor shrinkage.»

Dr. Joaquín Espinosa is enthusiastic about the results of his study, «The constant activation of the Interferon response could explain many aspects of Down syndrome, such as cognitive deficit, stunted growth, increased prevalence of autoimmune disorders, high risk of Alzheimer's disease, and protection against solid tumors.»

That increase came even as rates of colon and rectal tumors and deaths dropped in people 50 and older, researchers report online March 1 in CA: A Cancer Journal for Clinicians.

«These findings reveal a unique fulvestrant signaling process involving the increased regulation of hsa - miR - 765 that suppresses the HMGA1 protein as part of the mechanism underlying the tumor suppressor action in prostate cancer.

Loeb points out that much of the concern over cancer risk is that, as part of standard therapy for advanced prostate cancer, tumor growth is decreased by drugs that drastically reduce rather than increase male hormones.

However, evidence suggests that tumor genomic diversity might still defeat such combinations, and that it's axiomatic in oncology that side effects increase in number and intensity as more drugs are added to treatment.

«We also showed that as the number of mutant KRAS copies increases, the tumor's aggressiveness and ability to metastasize also increases.»

Researchers in Sweden sought to determine if use of tumor necrosis factor inhibitor drugs to treat RA would result in a reduced risk of acute coronary syndrome (commonly called ACS), defined as a diagnosis of a heart attack or unstable angina (the worsening or increasing cardiac symptoms)

The scientists also found consistent evidence of increased pro-inflammatory markers, such as C - reactive protein and tumor necrosis factor alpha, associated with PTSD.

Previous in vitro studies conducted by researchers in other countries showed that this molecule was able to reduce the multiplication and increase the mortality of cells from melanoma, the most aggressive type of skin cancer, as well as breast cancer and neuroblastoma, a tumor that typically affects patients aged 15 or younger.

Using chloroquine, the researchers not only increased the circulation of nanoparticles in the body, but also reduced the body's filtration of nanoparticles, as well as improved drug delivery to breast tumors.

Regrowth or progression of tumor was defined as any increase in size of known residual tumor on follow - up radiographic imaging.

Here, we show that ICB increased tumor vessel perfusion in treatment - sensitive EO771 and MMTV - PyVT breast tumor as well as CT26 and MCA38 colon tumor models, but not in treatment - resistant MCaP0008 and 4T1 breast tumor models.

NCI's efforts to develop new laboratory models of human cancer includes vastly increasing the number of human cancer cell lines (grown as two - dimensional and three - dimensional cultures) and patient - derived tumor xenografts.

In a first set of experiments, postdoctoral researcher and co-lead author Max - Felix Häring found that insulin increased the proliferation of mouse epithelial tumor cells in culture, as expected.

Transplanting non-cardiac stem cells also increases the risk for tumor formation, as many of the cells turn into other cell types besides the target heart cells.

Phosphatase and tensin homolog (PTEN): Adding an extra copy of the tumor suppressor gene PTEN to mice produces lower rates of cancer, much as expected, but also increased life span.

Previous studies have found that patient survival decreases as genetic diversity within tumors increases.

In the new study, published online March 27, 2018, in Cell Reports, a team led by UCSF's David Raleigh, MD, PhD, found that increased activity of a gene known as FOXM1 appears to be responsible for the aggressive growth and frequent recurrence of these tumors.

Other research is investigating whether agonist reagents that can signal various immune cells such as T cells, dendritic cells, or NK cells, through the TNF family receptors OX40, 4 - 1BB, HVEM, or LTβR can be used to increase natural immune responses to viruses or tumors that might lead to new strategies for vaccination.

Peptide Receptor Radionuclide and Octreotide: A Novel Approach for Metastatic Tumor - Induced Osteomalacia JES May 3, 2017 Abilash Nair, Semanti Chakraborty, Pramila Dharmshaktu, Nikhil Tandon, Yashdeep Gupta, Rajesh Khadgawat, Puthiyaveettil Khadar Jabbar, Chandra Sekhar Bal, Shipra Agarwal, and Mohd Ashraf Ganie Octreotide can be used as an adjunctive therapy to increase phosphorus levels in patients with tumor - induced osteomalTumor - Induced Osteomalacia JES May 3, 2017 Abilash Nair, Semanti Chakraborty, Pramila Dharmshaktu, Nikhil Tandon, Yashdeep Gupta, Rajesh Khadgawat, Puthiyaveettil Khadar Jabbar, Chandra Sekhar Bal, Shipra Agarwal, and Mohd Ashraf Ganie Octreotide can be used as an adjunctive therapy to increase phosphorus levels in patients with tumor - induced osteomaltumor - induced osteomalacia.

The increased precision will potentially allow treatment modalities beyond cancerous tumors to other malformations, such as trigeminal neuralgia, a painful neurological condition.

HHMI investigator Arul Chinnaiyan and colleagues at the University of Michigan showed that as prostate cancer develops and progresses, sarcosine levels increase in both tumor cells and urine samples, suggesting that measurements of the metabolite could aid in non-invasively diagnosing the disease.

Gb3 expression was detected independent of type (diffuse / intestinal), and was negatively correlated to increasing tumor - node - metastasis stages (P = 0.0385), as well as with markers for senescence.

It is defined as an increase of ≥ 25 % in total tumor size and / or number of tumors since the start of the trial.

Possible modes of hierarchy alteration are suggested as increased self - renewal (a), dedifferentiation of early progenitor cells (b), and blocked proliferation (c) of ER - α — positive and negative tumors.

Importantly, an inverse correlation was observed for ER - α — negative lines with a decrease in the proportion of MFC within the xenograft as tumor size increases (Fig. 5Bii).

Tumor hypoxia is often linked to decreased survival in patients with breast cancer and has been shown to induce specific molecular changes in cells including changes that confer a more malignant phenotype such as increased proliferation (3), survival (4), invasion (5), and metastasis (6).

The data presented in this article suggests that tumor subtype needs to be taken into account during treatment design as blocking angiogenesis and therefore increasing tumor hypoxia may be beneficial in the treatment of ER - α — negative breast cancer but could have catastrophic effects on ER - α — positive breast cancer.

Another reason is that stress prevents the elimination of lipids from the blood, and a third possible reason is that stress increases the production of a large number of inflammatory processes such as interleukin 6, tumor necrosis factor and C - reactive protein, which also increase production of lipids.

The research, which was funded by the Food and Drug Administration and other federal health agencies, contradicts numerous earlier studies that did find an increased risk of infection associated with the drugs, known as tumor necrosis factor (TNF) inhibitors.

The chronically stressed mice had decreased immune function and experienced tumor development significantly earlier than the non-stressed mice.16 Other mouse studies of ovarian cancer showed that chronic stress resulted in increased cancer growth as well as increased angiogenesis, the process with which cancer forms new blood vessels to feed itself nutrients for growth and metastases.17 Chronic stress has also been shown to decrease our body's ability to mount an attack against foreign invaders, including viruses.18 As we know that several viruses can cause cancer (HPV and cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risas well as increased angiogenesis, the process with which cancer forms new blood vessels to feed itself nutrients for growth and metastases.17 Chronic stress has also been shown to decrease our body's ability to mount an attack against foreign invaders, including viruses.18 As we know that several viruses can cause cancer (HPV and cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risas increased angiogenesis, the process with which cancer forms new blood vessels to feed itself nutrients for growth and metastases.17 Chronic stress has also been shown to decrease our body's ability to mount an attack against foreign invaders, including viruses.18 As we know that several viruses can cause cancer (HPV and cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risAs we know that several viruses can cause cancer (HPV and cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risk.

The detrimental effects of omega - 6s are articulated by Fernandes and Venkatraman (1993), with, «The increased consumption of many vegetable oils particularly of the n - 6 series is... viewed as pro-inflammatory and is suspected as one of the possible causes for the rise in certain malignant tumors, rheumatoid arthritis and autoimmune diseases primarily due to the increased production of pro-inflammatory cytokines» (p. S19).

Also, inflammation is thought to be a risk factor for most cancers, as increasing evidence links inflammation to all stages of tumor inception, growth and spread.

Researchers followed a subset of 1,139 subjects and found that those with the greatest increases in urinary polyphenols had significantly lower levels of five different biomarkers of inflammation, such as adhesion molecules, interleukin, tumor necrosis factor alpha, and monocyte chemotactic protein.

One study that administered strawberries to mice with colon cancer found tumor incidence to decrease as supplementation of strawberries increased.

Fasting and resistance exercise increases HGH+IGF 1 and HGH by 2000 % if they are done together, @ 20 - 23 hrs lets say, will this «internally» generated growth hormone surges also pose a potential problem if one has pre-cancerous condition such as polyps, tumors etc., as would eating meat / dairy etc?

Chemically - induced colon tumor incidence was increased in rats fed the semipurified diets containing 23 % corn oil, safflower oil, lard or beef tallow (high - fat) as compared to those fed 5 % corn oil, safflower oil, lard or beef tallow diets (low - fat).

Increased levels of circulating IGF - 1 as adults can promote unwanted growth, particularly in the form of tumors.

This disease - fighting nutrient can slow the growth and development of new blood vessels that nourish tumors, increase a type of programmed cancer cell death known as apoptosis and reduce the proliferation of new cancer cells.

Poor nutrition intake coupled with polluted environmental conditions increases the risk for respiratory cancers such as lung, tracheal and laryngeal tumors.

Given the well - established role of steroid hormones in breast cancer etiology for postmenopausal women, these findings may have important health implications» Tumor growth from these hormone imbalances is also evident «A dramatic increase in estrogen - dependent malignant diseases, such as ovarian, corpus uteri, breast, testicular and prostate cancers has been recognized.

And, although this effect may help to prevent heart attacks and other forms of heart disease, it may have the potential to promote cancer as well by increasing the growth of blood vessels in cancerous tumors.

While oxygen therapy alone did not influence cancer growth, the researchers found that combining keto and oxygen therapies together led to a significant decrease in blood glucose and tumor growth rate, as well as a 77.9 percent increased lifespan for the mice.

Spayed and neutered dogs have an increased incidence of mammary, testicular and ovarian tumors, as you might imagine, since these tumors are affected by the hormones.

The incidence of mammary tumors in cats is statistically similar as dogs, as is the predisposition to tumors increasing with each successive heat cycle.

Any dog can develop a tumor of the toe, but large breed, black coated dogs such as standard poodles, Rottweilers, Labrador retrievers and giant schnauzers have an increased risk of developing squamous cell carcinoma of the toe.

• Calcium (Ca +)-- Increased levels of calcium can be seen with diseases of the parathyroid gland and kidneys or as an indicator of certain types of tumors.

Reproductive disorders such as pyometra, mammary tumors, testicular cancer, ovarian cancer, and prostate cancer are also reduced / prevented with neutering (reviewed in [2]-RRB- although neutering has been associated with increased risk or aggressiveness of prostatic cancer [3 — 5].