Sentences with phrase «increases than other programs»

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These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (tprograms; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (tPrograms (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (tprograms; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Within program expenses, major transfers to persons were up $ 1.1 billion, primarily due to higher old age security payments, reflecting an increase in the number of recipients and higher inflation, as benefits are indexed to quarterly changes in the consumer price index, major transfers to other levels of government were up $ 0.6 billion, reflecting legislative increases; while direct program expenses declined by $ 0.2 billion, as lower «other transfer» payments more than offset increases in departmental / agency operating costs.

«Many investors expected a more lengthy FDA review process of the JCAR015 trial (and potentially other CAR - T programs) and feared that a higher - degree regulatory scrutiny could increase the development risk of CAR T cell,» Leerink Research said in a note co-authored by analysts Michael Schmidt, Ph.D., Jonathan Chang, Ph.D., and Varun Kumar, Ph.D. «While it may take several weeks to reopen all clinical sites of the ROCKET trial, we believe the trial shouldn't be delayed by more than ~ 3 months.»

For instance, you can stretch out Ferber's seven - day program over 14 days so that you increase the wait between checks every other night rather than every night.

Finally, strongman training can increase the speed of your fat loss and improve your overall body composition in less time than any other program you've tried.

A recent study published in Frontiers in Physiology found that accentuated eccentric loading (AEL)-- which involves lowering a weight slowly during the lengthening of the muscle, rather than letting it drop — might be more effective in avoiding a plateau then changing a program week to week.Scientists conducted a ten - week experiment involving three strength - training groups, with the AEL programming noting an increase in force production, work capacity, muscle activation and resistance compared to the other methods.

In some cases, Olympic weightlifting has been reported to increase 1RM back squat to a greater extent than other programs (Hoffman et al. 2004) but other programs have sometimes proved superior, which makes it difficult to draw definitive conclusions about the relative superiority of the training methods (Tricoli et al. 2005).

Everybody has a setpoint somepeople carry more weight than others, but to get those last few pounds off you really need to focus on your diet and increase your exercise program.

Results were statistically analyzed, finding that the program increased students» awareness and knowledge of their natural environments more than other outdoor education or community service activities.

In general, the opposition to Bush's proposal to give states increased responsibility for Head Start hinges on three arguments: 1) Head Start, as constituted, is an immensely successful program that should not be toyed with; 2) there is little evidence that states can do a better job than Head Start programs of improving children's school readiness; and 3) states, especially in the current budget environment, may try to reduce spending on Head Start in order to use the money for other purposes.

SMB: We should take a page from the successful, ongoing efforts that address the lingering lag in girls» and women's participation in STEM (Science, Technology, Engineering, and Mathematics) fields and leadership positions: 1) mentoring and role - modeling programs that involve more men in schools, particularly men who hold other than traditionally male jobs so that students see men in a variety of careers; 2) a national fathers» reading campaign to engage more fathers in reading to their children; and 3) increased funding for innovative programs that engage students in literacy activities in and out of school.

Other than inflationary adjustments authorized in 2010, there has been no increase in the $ 2.25 billion cap on E-rate resources since the program's inception in 1996, and demand has consistently been much higher than the available funding.

Despite what the lack of action on this issue suggests, however, there is widespread public support for increasing the selectivity of teacher preparation programs: 60 percent of Americans believe that preparation programs should make their entrance requirements more rigorous.11 While there has been some recent evidence of a shift, the average SAT scores of college students pursuing education degrees have historically been lower than those of students entering other professions.12

Scholars at the University of North Carolina Chapel Hill conducted a comprehensive evaluation of the teaching fellows program and found positive results, including a) graduates teach in schools and classrooms with greater concentrations of higher performing and lower poverty students; b) graduates produce larger increases in student test scores in all high school exams and in 3rd - 8th grade mathematics exams; and c) teaching fellows remain in North Carolina public schools longer than other teachers.

Eight of 11 empirical studies show that choice programs increase students» tolerance for the rights of others and the likelihood to vote, volunteer, or give more to charity than their public school counterparts.

Participation in voucher and education savings account (ESA) programs, which fund private school tuition and other educational expenses, has more than doubled in the past 5 years, with enrollment expansion increasing from about 70,000 to 147,000 and funds provided for the students increasing from $ 400 million to $ 859 million.

Students in public schools faced with increased private school competition showed greater gains in test scores than students in other public schools with the introduction of the program.

In 2009, the Justice Policy Institute noted that some states have begun to decrease the size of the prison population — thereby reducing spending — by providing community - based substance - abuse treatment programs, increasing rehabilitation efforts, improving parole mechanisms and services, and decriminalizing nonviolent offenses.105 States that intentionally decreased their prison populations saw crime decrease even faster than national averages.106 Other states should consider such reforms.

In addition to the activities described above, the FAST Act expanded eligible purposes to include financing economic development, including commercial and residential development, and related infrastructure and activities, that (i) incorporate private investment, (ii) is physically or functionally related to a passenger rail station or multimodal station that includes rail service, (iii) has a high probability of the applicant commencing the contracting process for construction not later than 90 days after the date on which the RRIF loan or loan guarantee is obligated, and (iv) has a high probability of reducing the need for financial assistance under any other Federal program for the relevant passenger rail station or service by increasing ridership, tenant lease payments, or other activities that generate revenue exceeding costs (Transit - Oriented Development Projects or TOD Projects).

, with increased fuel economy (an estimated 4 percent)- Best - in - class performance: 0 - 60 mph in under 7 seconds - New interiors with premium seating, soft - touch materials, redesigned controls, floor console with shifter, and nearly double the storage options - More than 35 new or improved features - Industry - first RamBox cargo management system (crew cab) includes versatile, weatherproof, lockable, illuminated and drainable storage bins built into bed rails (a total of 8.6 cubic feet of space); pickup bed divider / 2 - foot bed extender; and cargo rail system with four sliding, adjustable cleats - RamBox bins hold up to 10 cases of 12 - ounce beverages, or other gear for work or leisure - First - in - segment «store in the floor» storage bins with removable liners, big enough for ten 12 - ounce beverages and ice - First - in - segment heated and ventilated front seats - Heated rear seats also available - Heated steering wheel a first for any Dodge vehicle - First - in - segment coil - spring, multilink rear suspension fitted to a solid rear axle provides ride and handling capabilities unexpected in a pickup truck - First - in - segment live SIRIUS Backseat TV ™ - First - in - segment surround - sound audio system - More than 30 safety features, including standard four - wheel Anti-lock Brake System and Electronic Stability Program with Hill Start Assist and Trailer Sway Control - All - new 2009 Dodge Ram to arrive this fall - Light - duty diesel to arrive after 2009; two - mode hybrid powertrain to be offered in 2010 model year

With increased features come added confusion, and some programs are simply more intuitive than others.

By that point, the hopelessness of Federal social insurance programs like Social Security and Medicare, plus underfunded Federal and state retirement plans, will force benefit reductions and tax increases on the US, and crimp borrowing capacity, unless they borrow in a currency other than dollars.

Discussion: While we agree that gross earnings and earnings gains as a result of obtaining additional credentials will increase for program graduates over the course of their lives, and gains for some occupations may be more delayed than others, we do not believe that this merits increasing the D / E rates thresholds for the purpose of program accountability.

As the largest No Kill animal shelter in Kansas City, we care for more than 10,000 animals a year and work collaboratively with Animal Control and other animal welfare organizations to increase the number of homeless pets adopted, and focus on lifesaving programs promoting pet retention, identification, lost pet reunions, and pet ownership education throughout the community.

The key findings of this research were that: GIS can be a valuable tool in selecting a target for an intake reduction intervention as well as tracking program success; outreach tools can be a successful way to increase participation in programming; some outreach tools were more successful than others in increasing participation in the program; the intervention area owned cat intake decreased by a greater number (and percentage) than the control areas; the estimated percentage of owned intact cats that were spayed or neutered was higher for the intervention area; and, as the estimated percentage of owned intact cats that were spayed or neutered approached or surpassed 20 % for a given area the intake reductions were more profound.

Some progress in reducing euthanasia or increasing adoptions reported by participating shelters will inevitably be related to factors other than the five core Challenge initiatives (such as increased access to spay / neuter services or community - based trap - neuter - return programs).

In other words, shelters that are proactive, rather than passive, can help drive intakes and killing downward beyond a pet retention program in the shelter, working with rescue groups, adoption programs, and increasing reclaim rates (see also http://bit.ly/1050UPb).

- the game's shading mechanism has changed, which allows for increased gear texture quality - all graphical aspects and programming mechanisms have been built up from scratch for this sequel - maximum resolution is 1080p in TV mode - a bigger focus for Nintendo was the 60 frames per second - occasionally the resolution will be scaled down when there is too much ink displaying on the screen - Nintendo reduced the CPU load and refined the way to use CPU power effectively to maintain 60 fps in all matches - weapons were tweaked to let players be more creative by thinking about unique weapon characteristics and their best uses - weapons are designed to be effective when they are used during the right occasion - Special weapons are stronger than the original ones when used in the right situation, but weaker otherwise - the damage and effect of slowing down your movement when you step in the opponent's ink are reduced from original - you can jump up in rank if you're good enough, but only up until S - you can't jump up from C, B or A to S + - when you win battles in Ranked mode, the Ranked meter fills and your rank goes up when its fully filled - when you lose a battle, the gauge does not decrease, but the meter starts to crack - once the meter reaches its limit, it breaks - when the meter breaks, you have to start over again from the beginning or from a lower rank - highest rank is still S +, but if you fill up the Ranked meter, you get numbers after the alphabet such as «S +1», «S +2» and so on - maximum number is «S +50», but this number will not be displayed to your opponent - you are the only one to see it, and you can check it on your own status screen - Ranked Power is calculated by an algorithm to measure how strong each player is with minuteness - this will determine if a player's rank is worthy of receiving a big jump (like from «C» to «A»)- Ranked Power has no relation to your splat rate, and is more tied into to how well you lead your team to victory - you won't drop off more than one rank even if you play poorly - stage rotation time was changed to two hours - this was done because the devs expected people to play for an hour or so, but they found people play much longer - with Salmon Run, Nintendo considered how to implement a co-op oriented mode in a player - versus - player type of game - the devs will monitor how users are playing this mode to see if there's some tweaks they can throw in - more Salmon Run maps will be added in the future, but Nintendo wouldn't comment on adding more enemy types to the mode - rewards are changed each time Salmon Run is played - you can obtain rewards when playing locally, but not gear - originally Nintendo had an idea for this mode, but had no background setting, enemy designs, etc. - Inoue suggested that it should be salmon - themed - when Nintendo hosted the Splatfest that pit Callie against Marie, the development of Splatoon 2 had started - the devs had already decided to have the result reflected in the sequel - they even had an idea to announce the Splatfest with a phrase «Your choice will change the next Splatoon» - the timing to announce a sequel wasn't right, so they decided against this - they eventually released a series of short stories about the Squid Sisters to show how the Splatfest affected the sequel's story - Nintendo wouldn't say if Marina is an Octoling, and noted that Inklings are not paying attention to this too much - Inklings don't care about appearances, as long as everyone is doing something fresh - the Squid Sisters had composers who produced their songs, but Off the Hook are composing their music by themselves - Pearl is genius artist, but she couldn't find a right partner because she's a bit too edgy - she eventually found Marina as a partner though, and their chemistry is sparkling right now - Nintendo is planning a year of content updates for Splatoon 2 - when finished, the quantity of stages will be more than the original - some of the additional stages are totally new and some will be arranged stages from the first game - not all original stages will return and they are choosing stages based on the potential for them to be improved - Brella is shotgun-esque weapon, so the ink hits your opponent more if you are closer - it can shield damage when you open it, but the amount of damage has a limit and once it reaches it, it breaks - you can shoot ink, but you can't use the shield feature when it breaks - the shield won't prevent your allies ink - there are more new weapon categories which haven't been revealed yet - there are no other ranked modes outside of the three current options - the future holds any sort of possibility, but the devs didn't get specific about adding more content like that - for the modes, they adjusted the rule designs so that players will experience the more interesting aspects

Beginning in the late 1980s, with exhibitions organized by curators William Olander and Laura Trippi, the New Museum placed increasing emphasis on areas other than painting and sculpture, and presented film, video, television, photography, and performance works as a regular part of the exhibition program.

But a closer look at the findings reveals why demand response may be worth more in some states than in others, and how the value can increase over time for successful programs.

Comprehensive intersectoral programs that combine measures to control deforestation and forest degradation with measures to increase agricultural productivity and sustainability will likely contribute more to reducing vulnerability of forests to climate change, land use change and other stress factors than independent sectoral initiatives.

Faced with shrinking government grants and tuition caps for other programs, the University of Windsor raised law tuition from $ 4,010.36 per year in 1998 to $ 14,556.60 today — an increase of more than 300 %, far greater than the rate of inflation.

It is important to keep in mind that more often than not of «Level Benefit» insurance with other programs, the rates usually do not increase for your policy term length.

Advanced through program faster than other trainees by maintaining commitment to continually increasing knowledge and skills.

• Secured more than 4 of the top 10 national homebuilders, rolled out innovative national program for Florida - based Lenner Home Builders, the second largest homebuilder in the United States, and numerous other record sales and marketing strategies that gained market and revenue company increases.

Reduced Trauma Symptoms and Perceived Stress in Male Prison Inmates through the Transcendental Meditation Program: A Randomized Controlled Trial Sanford Nidich, EdD; Tom O'Connor, PhD; Thomas Rutledge, PhD; Jeff Duncan; Blaze Compton, MA; Angela Seng; Randi Nidich, EdD Trauma events are 4 times more prevalent in inmates than in the general public and are associated with increased recidivism and other mental and physical health issues.

Three reviews, bridging somewhat different topics and using different methods for comparing the efficacy across groups, have all concluded that minority children and families appear to benefit as much as or more than other groups from evidence - based interventions like those proposed here.75 At the same time, because the success of a program depends importantly on participants» remaining engaged until they complete the program, as well as the fidelity with which the program is delivered, cultural adaptations that increase the likelihood of optimal delivery and receipt of these programs to practitioners, parents, and children would seem well warranted.76

Barkley et al found increased rates of comorbid substance abuse disorder, anxiety disorder, mood disorder, personality disorders, and disruptive behavior disorders among adults with ADHD that had persisted from childhood into adulthood.23 Adults whose childhood ADHD did not persist also had increased rates of psychiatric comorbidity, although lower than those with persistent ADHD (47.3 % vs 84.3 %).23 Other smaller studies also report elevated rates of psychiatric comorbidity (65 — 89 %) among adults with ADHD.15 — 22 However, these studies used nonrepresentative samples of children referred to specialty treatment programs for ADHD.

In other words how is it even with the increased level of expenditures and the many programs that you've described that I think are all quite laudable, so how is it that a country like Australia with the resources it has, has not yet been able to bring what's less than 2 % of the population up to reasonable levels in terms of standards of living?