Sentences with phrase «increasing amyloid»

But in human cells, scientists noticed apoE4 has a very clear effect on increasing amyloid beta production, which highlights the species difference in the way apoE4 controls amyloid beta metabolism.

They also intend to incorporate functional imaging into their research to learn about how the relationship between function and structure is affected with increasing amyloid burden.

Low levels of progranulin can impair this process, leading to increased amyloid beta deposition.

Reducing progranulin markedly increased amyloid - beta plaque deposits in the brain as well as memory impairments.

The study suggests that «a slow - gamma deficit might be part of this [Alzheimer's disease] pathogenesis [and that] manipulating slow - gamma activity... could be a new way to suppress amyloid - β production and increase amyloid - β clearance,» Huang added.

«Increased amyloid beta production is not seen in mouse neurons and could potentially explain some of the discrepancies between mice and humans regarding drug efficacy.

«This study affirms that disrupted sleep may be a risk factor for Alzheimer's disease via increased amyloid.»

Further research is needed to learn more about the connection between lower body weight and increased amyloid levels, the investigators noted.

Increased amyloid β - peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late - onset Alzheimer disease.

According to the authors, vascular damage may predispose your brain to increased amyloid plaque buildup, which is a hallmark of this degenerative brain disease.

The inflammation both degenerates brain tissue and increases amyloid beta, the hallmark of Alzheimer's.

A new study from the Washington University School of Medicine in St. Louis shows that lack of sleep increases amyloid beta, a protein linked to Alzheimer's.

Not exact matches

The actual process of vascular aging may predispose a person's brain to the increased amount of amyloid plaque buildup.

In addition, compared to mice on a regular diet, brain cells from animals in the olive oil group showed a dramatic increase in nerve cell autophagy activation, which was ultimately responsible for the reduction in levels of amyloid plaques and phosphorylated tau.

When compared to other symptoms of depression such as sadness or loss of interest, anxiety symptoms increased over time in those with higher amyloid beta levels in the brain,» said first author Nancy Donovan, MD, a geriatric psychiatrist at Brigham and Women's Hospital.

In both trials, levels of two proteins that play major roles in transporting beta - amyloid out of the brain as well as enzymes that degrade beta - amyloid increased significantly after administering oleocanthal.

While these compounds did not reduce the amount of protein aggregates, they were found to reduce the protein's toxicity and to increase the stability of amyloid fibrils — a finding that lends further evidence to the theory that smaller assemblies of amyloid - beta known as oligomers, and not the fibrils themselves, are the toxic agents responsible for Alzheimer's symptoms.

The researchers compared each participant's amyloid beta and tau levels after the disrupted night to the levels after the uninterrupted night, and found a 10 percent increase in amyloid beta levels after a single night of interrupted sleep, but no corresponding increase in tau levels.

Specifically, the release of a stress - coping hormone called corticotropin - releasing factor (CRF), which is widely found in the brain and acts as a neurotransmitter / neuromodulator, is dysregulated in AD and is associated with impaired cognition and with detrimental changes in tau protein and increased production of amyloid - beta — protein fragments that clump together and trigger the neurodegeneration characteristic of AD.

He added that the purpose of this study was to investigate the associations between OSA severity and changes in AD biomarkers longitudinally, specifically whether amyloid deposits increase over time in healthy elderly participants with OSA.

The authors said this finding is compatible with an increase in amyloid deposits in the brain; the finding was confirmed in the subset of participants who underwent amyloid PET, which showed an increase in amyloid burden in those with OSA.

The study noted increased levels of amyloid beta in a large group of patients with no hereditary risk gene.

Previous studies have shown a link between increased brain activity and beta - amyloid deposits, but it was unclear whether the activity was tied to better mental performance.

«Lack of sleep may be linked to risk factor for Alzheimer's disease: Preliminary study shows increased levels of beta - amyloid.»

In Alzheimer's disease, beta - amyloid is estimated to increase about 43 percent in affected individuals relative to healthy older adults.

While approximately 80 percent of Alzheimer's disease patients also have cerebral amyloid angiopathy, or amyloid beta deposits in the brain's blood vessels that increase the risk for stroke and dementia, the predominant amyloid beta pathology is plaques.

«Interestingly, though, amyloid beta deposition was higher in blood vessels than in plaques, and this correlated with increases in tau lesions,» said Melissa Edler, Ph.D., lead author and former doctoral student in biomedical sciences at Kent State.

It is unknown whether the increase in beta - amyloid in the study participants would subside after a night of rest.

Losing just one night of sleep led to an immediate increase in beta - amyloid, a protein in the brain associated with Alzheimer's disease, according to a small, new study by researchers at the National Institutes of Health.

In a key memory experiment in the study, mice brains were injected with beta - amyloid, whose increase is one hallmark of Alzheimer's in humans.

«We suspect that as amyloid plaque load in the gray matter increases, the brain's white matter starts to break down or malfunction and lose its ability to move water and neurochemicals efficiently,» added Dr. Prescott.

But in APOE4 or APOE3 mice with earlier - stage AD, the amount of soluble amyloid - beta actually increased.

We think of this increase as a compensatory response that could protect against insults from this amyloid - β.

They then directly linked high synaptic activity to amyloid - beta increases.

«When we decreased the levels of STI1, the neurons became more sensitive to attack by amyloid - β, and when we increased the STI1, it seemed to mitigate or decrease the toxicity of amyloid - β.»

The drug, bexarotene, was found to reduce levels of the neurotoxic protein amyloid - beta in experimental mice with late - stage Alzheimer's but to increase levels during early stages of disease.

Several of these changes increase β amyloid formation and cause a devastating inherited form of Alzheimer's that afflicts people in their 30s and 40s — much earlier than the far more common «late - onset» form of Alzheimer's that typically strikes people their 70s and 80s.

Islet amyloid, increased A-cells, reduced B - cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes

Replication increases β - cell vulnerability to human islet amyloid polypeptide - induced apoptosis

But the findings do match up with studies in mice where PPIs increased a protein called beta - amyloid in their brains, the hallmark of Alzheimer's disease.

The age - related memory loss is related to an increase in β - amyloid in the hippocampus.

Such scans could help researchers determine if people with type 2 diabetes have elevated amounts of amyloid which may contribute to their increased risk for Alzheimer's disease.

«Interestingly, though, amyloid beta deposition was higher in blood vessels than in plaques, and this correlated with increases in tau lesions,» said Dr. Melissa Edler, lead author and former doctoral student in biomedical sciences at Kent State.

Increasing evidence suggests that the synaptic functions of the amyloid precursor protein (APP), that is key to Alzheimer (AD) pathogenesis, may be carried out by its secreted ectodomain.

New research has linked increasing symptoms of anxiety in older adults to higher brain levels of beta - amyloid, a protein linked to Alzheimer's disease.

Losing just one night of sleep led to an immediate increase in beta - amyloid, a protein in the brain associated with Alzheimer's disease, according to...

«We are working to increase our understanding of Alzheimer's disease all the time, and there are already a number of drugs in clinical testing that are targeted against amyloid.

Washington University scientists found that a lack of sleep could increase the protein amyloid beta, a protein linked to Alzheimer's disease.

Abstract: Gain - of - function mutations in the presenilin - 1 (PS - 1) promote Alzheimer's disease (AD) by increasing reactive oxygen species, at least part of which is derived by an accompanying increase in generation of amyloid - β (Aβ).

Administered in the food of 20 - month - old genetically engineered mice, at a stage when Alzheimer's pathology is advanced, J147 rescued severe memory loss, reduced soluble levels of amyloid, and increased neurotrophic factors essential for memory, after only three months of treatment.