Sentences with phrase «increasing human breast cancer»
«It is believed that environmental and lifestyle factors, such as diet, play a critical role in increasing human breast cancer risk, and so we use animal models to reveal the biological mechanisms responsible for the increase in risk in women and their female progeny,» says Hilakivi - Clarke.
https://gumc.georgetown.edu/ Not exact matches
NAMPA appears to imply that we should ignore advice such as this one issued on May 21st from Harvard's School of Public Health: «With increasing evidence of the potential harmful effects of BPA in humans, the authors believe further research is needed on the effect of BPA on infants and on reproductive disorders and on breast cancer in adults.»
In tumors formed by human breast cancer cells, DNA damage (brown staining) is increased by simultaneous Olaparib treatment and PGAM1 suppression (right) when compared to either Olaparib treatment (left) or PGAM1 suppression (center) alone.
«Thus, exposure to EDCs may significantly increase the risk of breast cancer development and adversely affect human health,» the researchers state in the paper.
Previous evidence for a breast cancer link has been mixed — one study found increased risk in women exposed before age 14, whereas others found no association — but in a lab dish, DDT has been shown to activate the HER2 gene in human breast cells, which is expressed in some breast cancers.
Disruption of the circadian rhythm carries human health impacts, including an increased risk of breast cancer, metabolic diseases such as type - 2 diabetes and mood disorders, he said.
Some experts have traced estrogen - like chemicals to increased rates of human breast cancer, and there is even more evidence that they endanger animals by feminizing the sex organs of male frogs and fish living downstream from sewage treatment plants.
Additionally, overexpression of POSTN in human mammary epithelial and breast cancer cells resulted in enhanced tumor growth and metastasis (Wang et al., 2013), which is similar to a colon cancer cell model where overexpression of POSTN resulted in an increase in the number and size of liver metastases (Bao et al., 2004).
Mutations in the gene increase rat susceptibility to mammary cancer and FRY reduced the growth of highly aggressive human breast cancer cells.
IGFBP5 induces cell adhesion, increases cell survival and inhibits cell migration in MCF - 7 human breast cancer cells.
Low levels of a tiny RNA fragment in cells are associated with metastatic breast cancer in humans and increases the aggressive spread of breast cancer in mice, according to researchers at Whitehead Institute for Biomedical Research.
Recent reports show increased CSC activity following hypoxic exposure in breast cancer cell lines (18 — 20), but no reports have studied this rare population in primary human breast cancer samples.
There is also now abundant research that links BPA and phthalate exposure to such human health concerns as deformities of the male and female genitals; premature puberty in females; decreased sperm quality; and increases in breast and prostate cancers, infertility, miscarriages, obesity, type 2 diabetes, allergies and neurological problems, like attention deficit hyperactivity disorder.
«We not only uncovered the biological pathway stimulating cancer growth, but we found a compound that blocked it, increasing the survival of mice carrying human metaplastic breast tumors,» Chang says.
Epidemiologic data has shown that chronic depression, stress, and lack of social support are all risk factors for cancer.14 A study in humans even showed chronic depression and even the death of a mother during childhood to be associated with increased breast cancer in women.15 While we do not have concrete evidence in humans, animal studies more definitively point to stress as a cause of cancer.
«[I] ncreased dietary cholesterol intake [may result] in increased breast cancer risk,» and may at least partially explain the benefit «of a low - fat diet on [lowering] human breast cancer recurrence.»
Studies of Gluts in human tumors have shown a significant increase in the abundance of Glut1 and Glut3 mRNA in cancers of the esophagus, colon, and pancreas, overexpression of Glut1 and Glut3 mRNA and Glut1 protein expression in head and neck tumors and Glut1 protein overexpression in breast and renal cell carcinomas
Originated 1970s by Dr. Henry Lemon, who tested estrogen levels in 24 hour urine samples and found that an EQ > 1 strongly correlated with a higher survival rate after breast cancer.24 Further research conducted by Lemon, Heidel, et al., a meta - analysis of published fractional estrogen excretion collected from 2,846 healthy women worldwide aged 15 to 59 years, with a risk of breast cancer varying five-fold, found that an EQ < 1 reflects increased rates of oxidation of estrone or estradiol to 4 - OH catechols (also referred to in the literature as the 3,4 - catechol estrogen quinones), which have been identified as the principal proximal human mammary carcinogens after menarche, while an EQ > 1 reflects conversion to protective 2 - OH estrogen metabolites.2526
(21 - 22)(39) Three previous large scale human studies revealed increased breast cancer with progestin use.
Most human trials are not carried out long enough to detect any increase in cancer rates, but in one trial, breast cancer rates of those taking a statin were 1500 percent higher than those of controls.