Sentences with phrase «increasing number of combinations»

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

But a growing number of analysts and market watchers say the combination of increased rail capacity and alternative pipeline projects has made the cross-border segment redundant.

This increases the number of possible weight combinations for each weigh cycle.

The hoppers on a multi-head weigher can vary from 8 to 36, the increase in number of hoppers increases the speed and accuracy as the number of permutations and combinations for filling increase.

In combination with these menu changes the lunch price increased from $ 2.25 to $ 2.50 per meal for the full price lunch, most likely decreasing the number of full priced lunches purchased.

Increase your total number of feeds over 24 hours by breastfeeding your baby, using a pump, hand expression or combination of all three to drain the breasts really well.

Administration officials said the true deficit number at the start of the process was $ 4.4 billion and that keeping state spending to the 2 percent cap level — which got things down to a $ 1.7 billion deficit — took a combination of spending cuts and proposed tax increases.

ERIE COUNTY, NY — The Erie County Medical Examiner's office reports a recent increase over the past month in the number of suspected drug overdose deaths involving the drug fentanyl, either alone or in combination with other drugs such as heroin and cocaine.

«These findings are extremely encouraging and suggest that with sustained commitment to increase the number of people who use combination HIV prevention, it may be possible to achieve epidemic control and eventual elimination of HIV,» said David Serwadda, M.B.Ch.B., M.Med., M.P.H., co-founder of the Rakai Health Science Program and Professor at Makerere University School of Public Health in Kampala, Uganda.

Data from the clinical trial did show that the combination therapy substantially decreased the number of pulmonary exacerbations and hospitalizations, while also beneficially increasing the weight of CF patients.

Each time another electric vehicle is plugged in, this increases the number of possible combinations of simultaneous charging situations distributed geographically and over time.

The continued fall in transmission rates is thought to be due to a combination of factors including earlier initiation of antenatal combination antiretroviral therapy (cART) and an increase in the number of women already on cART when they conceive.

The increase could be the result of an increase in the resident population, in the number of visiting dolphins or a combination of both.

The report lists 30 cities that face increased health risks from heat waves worsened by global warming, based on a combination of four factors: average number of summer days with «oppressive» summer heat, the percentage of households without central air conditioning, ground - level ozone levels, and the percentage of households below the poverty line.

In previous studies, we showed that the increase in muscle mass in Mstn − / − mice results from a combination of increased fiber numbers and increased fiber sizes [2].

As per - seat fuel efficiency of jet airliners improved, a combination of cheaper fares, increasing incomes, and a growing population raised the number of airborne humans from millions in the 1960s to the current four billion a year.

For for an increasing number of beamlines we offer specialized sample environment equipment in combination with direct user service.

You have to rely on the combination of both to really increase your numbers.

This condition is a combination of medical disorders that increase the risk of developing cardiovascular disease and diabetes.It affects a great number of people, and prevalence increases with age.

The reasons for these increasing numbers seem to stem from a combination of both genetic and environmental factors.

A significant number of people are becoming increasingly sensitive to low exposures to 2,4 - D and many other chemicals.16 This increasing sensitivity may be due to a combination effect of simultaneous exposure to estrogenic nonylphenols15 mixed with locally sprayed herbicides, which are also highly estrogenic, and to antiandrogenic wind drift fungicides, 17 as well as to many other airborne chemicals.

PRODUCT PERKS Explore numbers, patterns, measurement, grouping, and more with this set of colorful tiles Tiles can supplement lessons in counting, addition, subraction, grouping, pattern matching, and more Four vibrant colors (red, blue, yellow, and green) Soft, durable, and quiet foam material WHAT TO TEACH Sorting - Sort the Color Tiles into unique groups Patterns - Create patterns using Color Tiles One More and One Less - Comparing numbers 1 through 10 Number Sense - Exploring the numbers 0 through 10 Make Ten - Increasing number sense by investigating the combination of Color Tiles needed to make a train of 10 tiles Addition - Developing the concept of addition Measuring - Take common objects for size comparison and estimate which object is longer Fractions - Introduce fractions Probability - Investigate probability Logical Thinking - Exploring problem solving and spatial reasoning RESOURCES Learning About... Color Tiles INCLUDES 400 Foam Color Tiles 1 Storage conNumber Sense - Exploring the numbers 0 through 10 Make Ten - Increasing number sense by investigating the combination of Color Tiles needed to make a train of 10 tiles Addition - Developing the concept of addition Measuring - Take common objects for size comparison and estimate which object is longer Fractions - Introduce fractions Probability - Investigate probability Logical Thinking - Exploring problem solving and spatial reasoning RESOURCES Learning About... Color Tiles INCLUDES 400 Foam Color Tiles 1 Storage connumber sense by investigating the combination of Color Tiles needed to make a train of 10 tiles Addition - Developing the concept of addition Measuring - Take common objects for size comparison and estimate which object is longer Fractions - Introduce fractions Probability - Investigate probability Logical Thinking - Exploring problem solving and spatial reasoning RESOURCES Learning About... Color Tiles INCLUDES 400 Foam Color Tiles 1 Storage container

An increasing number of high performance brake rotors feature disc slots, cross-drilled holes or a combination of both.

The number combinations identifying the performance levels in the Audi product range increase in increments of five, and they represent the hierarchy within both the respective model series and the brand's overall model range.

The TFSI / Quattro combination, which will power the lion's share of North American A4s, is a capable partner, with a newly fortified 252 horsepower and 273 pound - feet of torque (increases of 32 and 15, respectively) thanks to a number of tweaks including a redesigned cylinder head, variable valve lift, dual - mode fuel injection and an electronic wastegate on the turbo.

As we face the inevitable summer interest rate hike, an increasing number of Canadian homeowners are opting for combination mortgages, in which part of the principal is paid off at a fixed interest rate, and part is paid off at a variable rate.

The relative risk (RR) of producing affected offspring was found to increase with the number of affected parents in the breeding combination.

This gland has a number of functions, but the important ones can be revealed and one sees what can happen when it does not work properly: loss of haircoat (alopecia), weight gain and edema, poor heat - stress tolerance, increased dandruff, itching to the point of self - mutilation, smelly crud build - up in the ear canals, rancid body odor (especially in mature dogs), decreased fertility, lethargy, poor digestion and stool condition, possible fever, darkened skin, lowered resistance to flea infestation, or any combination of these.

«The distinction between compensatory and additive mortality does, however, become increasingly redundant as the number of birds killed in a given area increases: where large numbers of prey are killed, predators would probably be killing a combination of individuals with poor and good long - term survival chances.

Special potions can also be equipped, the number of slots depending on your characters level, they can provide increases to health, increased critical chances or an increased number of health recovery bottles to name but a few.The balance of tinkering should please both action and RPG fans, it is quick and easy to decide what to use while still providing enough combinations to find the best set ups if you wish.

One of the items mentioned allows the player to increase the number of accessory slots, further enhancing various build combinations.

Adding CO2 is a combination of directing more data into the buffer (absorption spreading) and lengthening the buffer (increasing the average number absorptions per photon / reducing the mean distance between absorptions).

paper that seems to have had such an effect on Joules Verne, some numbers might be useful: h = kb * T / (m * g) = 9.08 km for N2 at 300K λ = 68nm at 101325 Pa To get λ ~ 0.01 h where the deviation from the Fourier Law is ~ 10 % requires a reduction of pressure of 11 orders of magnitude to ~ 1E - 6Pa or an increase of g of a similar magnitude or some combination of both that increases λ and reduces h. I'm not going to touch the temperature gradient as that's even worse.

NOAA predicts a significant increase in the number of tidal flooding events all up and down the East Coast due to a combination of El Nino and impacts related to human - forced climate change.

The combination of a projected two thirds increase in numbers and our present level of consumption would be environmentally disastrous.

From 2000 onwards, firms were keen to convert to LLP status, and now we are seeing an increasing number set up as a corporate, while a handful are PLCs or a combination of structures.

Traditionally, for firms to grow their revenue, they needed to do one or more of the following: A) increase the number of producers (timekeepers); B) increase the rate of production (billable hours); C) increase the unit price (hourly rate); D) A combination of A, B, and / or C.

Robin Allen QC, Chair of the Bar Council's Equality and Diversity Committee, said: «The progress made in recruiting more female judges is to be welcomed; but there is an urgent need to increase the number of part - time salaried posts which offer a useful combination of certainty and flexibility for the large number of lawyers with caring responsibilities.

It may be that the increased number of lawyers will simply increase competition for limited work — or it may be that innovation will result in new services being provided to Ontarians — or there may be some combination of both.

That is why it is planning to increase number of parts that will be used for iPhones and is looking into combination of a face recognition module with a camera module.

The new data center, which will be KnC's fourth data center in The Node Pole, is a direct response to a growing market demand, where not only cryptocurrency functions but also a growing number of other blockchain technology applications drives an increasing global market demand for smart and efficient computing capacity — an area where KnC's combination of smart computing hardware, software models and attractive business applications has led to them dominating in the global market.

In contrast, North America saw the greatest increase in the number of imported workers; a combination of a post-Macondo surge in Gulf of Mexico activity coupled with several LNG projects moving into construction phase has continued to drive the need for expat workers with specialist knowledge.

Oahu Kauai Maui & Hawaii About Blog Our mission is to enhance Hawaii's food security and economy by increasing the number of local agricultural producers by offering those with an interest in agriculture a combination of knowledge, experience, and support designed to assist them in becoming viable production growers, and accomplish this in a manner that encourages sustainability.

An increasing number of career training schools now offer combination programs, which lead to cardio - phlebotomy technician diplomas that should be of particularly high interest to medical assistants.

And an increasing number of developers are focusing their projects around this concept, hoping their wide variety of health - focused amenities will be a winning combination to attract buyers» attention.

The United States housing market was adversely impacted beginning in 2006 by the combination of a number of factors, including but not limited to more stringent lending guidelines, increased unemployment, and an overall macroeconomic decline.