These data suggest that ABL kinases promote breast cancer metastasis to bone in part by
increasing tumor cell survival within the bone microenvironment.
Not exact matches
Again, using mouse models of glioblastoma — this time created from brain
tumor cells that were resistant to the herpes virus — the therapy led to
increased animal
survival.
«One of the major and immediate downstream effects of myc activation is a dramatic
increase in the capacity of affected
cells to make protein,» Ruggero said «This, in turn, leads to
increased cell survival and proliferation, and to unstable genomes that foster additional mutations that turn these abnormal
cells into
tumor cells.»
Among patients with non-small
cell lung cancer (NSCLC) fueled by ALK gene alterations who were being treated with crizotinib (Xalkori), a decrease in the number of circulating
tumor cells (CTCs) harboring
increased copies of the ALK gene over the first two months of treatment was associated with
increased progression - free
survival.
Morris says vaccination with modified
tumor cells producing IL - 15 and IL - 15Rα slowed
tumor growth and led to
increased survival for animal models.
Their results demonstrate that specific rhoptry and dense granule effector proteins that T. gondii secretes before and after host
cell invasion, respectively, control the development of an effective host antitumor response, and
increase the
survival of mice with ovarian
tumors.
«A way to stabilize haploidy in animal
cells: Mammalian haploid
cells present problems during mitosis that limit their viability; the removal of the p53
tumor suppressor gene
increases the
survival rate of these
cells thereby stabilising their haploid state.»
Moreover, injection of 5E5 CAR T
cells into mice with leukemia or pancreatic cancer reduced
tumor growth and
increased survival.
The prognosis for metastatic cancer (also called stage IV cancer) is generally poor, so a technique that could detect these circulating
tumor cells before they have a chance to form new colonies of
tumors at distant sites could greatly
increase a patient's
survival odds.
Injecting the TRAIL - expressing stem
cells into the carotid artery, a likely strategy for clinical application, led to significantly slower
tumor growth and
increased survival, compared with animals receiving unaltered stem
cells or control injections.
Recently, we showed that bortezomib treatment in mice bearing breast and kidney
tumors provided host
survival benefit by amplifying
tumor cell caspase8 activation, CD8T
cell effector molecules via
increased NotchNFkB crosstalk and Fas ligandmediated lysis of
tumor cells.
Now, in a new study in the journal Cancer
Cell, Shaw and a team of scientists at the Salk Institute for Biological Studies found that phenformin, a derivative of the widely - used diabetes drug metformin, decreased the size of lung
tumors in mice and
increased the animals»
survival.
Injections of iPSC - EPCs did not however have significant effect on
tumor growth or on overall
survival, but transducing
cells with a baculovirus expressing CD40L, a member of the TNF gene family which can induce apoptosis [6, 7], and injection into the breast cancer lung metastasis,
increased levels of pro-apoptotic cytokines in lung tissues, indicating the induction of apoptosis by CD40L carried by the EPCs (See figure).
Dr. Sadelain's work has focused on developing novel strategies to extend
survival of CAR T
cells in the body and enable T
cells with
increased potency to overcome the resistance imposed by
tumor and other
cells in the
tumor microenvironment.
The CRISPR - Cas9 genome editing system could help fight cancer, and now, researchers have used the tool to target what they call cancer's command center, in a treatment that's been shown in mice to shrink aggressive
tumors and
increase survival rates, without harming healthy
cells.
Tumor hypoxia is often linked to decreased
survival in patients with breast cancer and has been shown to induce specific molecular changes in
cells including changes that confer a more malignant phenotype such as
increased proliferation (3),
survival (4), invasion (5), and metastasis (6).