Sentences with phrase «increasing use of mice»

But the biggest factor appears to be the increasing use of mice and rats in biomedical research.

Not exact matches

Again, using mouse models of glioblastoma — this time created from brain tumor cells that were resistant to the herpes virus — the therapy led to increased animal survival.

To improve on this result, the researchers used recombinant DNA techniques to generate purified recombinant proteins from the designed multiepitope DNA strings, and gave the mice a series of protein booster shots to increase their immune response.

When researchers used optogenetics — a technique that allows cells to be switched on and off with light — to increase the amount of bursting in the lateral habenula, mice behaved in a more «depressed» way, remaining motionless when forced to swim in a container of water, for example.

St. Jude Children's Research Hospital scientists have reported a promising new approach that uses an investigational cancer drug to dial down viral production and dramatically increase survival of flu - infected mice.

In mice, this form of lipodystrophy was also characterized by «whitening» of brown fat cells, a loss of white fat, and signs of metabolic syndrome, including insulin resistance, fat tissue inflammation, dyslipidemia (elevated cholesterol and fat), increased resting energy use, and increased markers of cardiovascular disease.

Two compounds already approved for use in humans increased the survival of lab mice even after they were exposed to radiation

To test whether increased levels of Oprl1 could treat or prevent the mice's PTSD symptoms, Ressler and his colleagues used a newly developed compound from the Scripps Research Institute that activates the receptor.

They used a somewhat bizarre technique in which two mice were sutured together in such as way that they shared a circulatory system (known as parabiosis), and found old mice joined to their youthful counterparts showed changes in gene activity in a brain region called the hippocampus as well as increased neural connections and enhanced «synaptic plasticity» — a mechanism believed to underlie learning and memory in which the strength of neural connections change in response to experience.

Various mouse lines have been developed to express proteins that can be used to visualize changes in concentrations of calcium, which increase when neurons become active.

By contrast, a signal of tumor activity increased sixty-fold in mice treated with the widely used chemotherapy drug gemcitabine.

«Triclosan's increasing detection in environmental samples and its increasingly broad use in consumer products may overcome its moderate benefit and present a very real risk of liver toxicity for people, as it does in mice, particularly when combined with other compounds with similar action,» said Robert H. Tukey, PhD, professor in the departments of Chemistry and Biochemistry and Pharmacology.

That's the claim of a new study, which finds increases in metabolic disease and intestinal inflammation in mice fed two common emulsifiers used in processed food.

After tracking the injected cells in the mice for more than 10 days using bioluminescence and fluorodeoxyglucose (FDG)- positron emission tomography (PET) imaging, they found that the injection of the senescent cells into the knee region caused leg pain, impaired mobility and characteristics of osteoarthritis, including damage to surrounding cartilage, X-ray changes, increased pain and impaired function.

Also, when pregnant mice were exposed to tributyltin, which is no longer licensed for use as a fungicide, their children and grandchildren who weren't exposed had increased body fat, according to a new study from the University of California, Irvine.

When they turned up the volume on the signal, using gene therapy techniques to increase the production of the signaling molecule, the mice with CMT regained muscle strength and their ability to walk improved significantly.

They have found this can greatly increase the time that transplants survive in rats and mice, although the use of the technique in humans is a long way off.

Depletion of gram - positive bacteria within the gut, using an antibiotic called vancomycin, also increased the efficacy of the therapy, improving the anti-tumor response and overall remission rate in less - responsive mice.

Using mice that had been manipulated to develop MS, the researchers discovered that chronic MS leads to significantly increased levels of succinate, a small metabolite that sends signals to macrophages and microglia, tricking them into causing inflammation, but only in cerebrospinal fluid, not in the peripheral blood.

«We have shown for the first time that increasing synaptic connectivity within engram cell circuits can be used to treat memory loss in mouse models of early Alzheimer's disease,» says lead author Dheeraj Roy.

Harmonising ontological descriptions of phenotype in mouse and human and improving links between mouse model data and human data, using diabetes and obesity as examples, will increase the relevance of data that is generated in mouse studies for clinical studies.

Now, in a new study in the journal Cancer Cell, Shaw and a team of scientists at the Salk Institute for Biological Studies found that phenformin, a derivative of the widely - used diabetes drug metformin, decreased the size of lung tumors in mice and increased the animals» survival.

Using studies in both mice and humans, they found that exposure to farm dust increases expression of a protective protein that suppresses the inflammatory immune system by modifying the communication between the lining of the lungs and the immune system.

«The number of mice used in genetic and transgenic experiments is increasing.

«We have shown for the first time that increasing synaptic connectivity within engram cell circuits can be used to treat memory loss in mouse models of early Alzheimer's disease,» said lead author Dheeraj Roy in a release.

In another experiment, the researchers used viral gene transfer and increased RbAp48 expression in the DG of aged mice.

[19] In the current study, [15] PDGF - AS mice exhibited an increased number and intensity of areas staining for reactive microglia (using Iba1) and astroglia (using GFAP), but vaccination with AFF 1 prevented nearly all of this disease - associated excess, with treated animals exhibiting only the burden of reactive glia present in similar - aged WT mice.

Using gene therapy to increase the levels of progranulin in the mice, they reversed the symptoms.

Potential projects include identifying common pathways that modify retinal degenerative disease from a large collection of actively maintained mouse models; determining molecular networks implicated in pathological disruption of the retinal pigment epithelium; identifying molecular pathways that regulate postnatal ocular growth; and using mouse models to assess the pathogenic role of gene variants that increase the risk of age - related macular degeneration as identified by human genome - wide association studies.

Using diabetes and obesity as framework, Phenobridge will increase the relevance of data that is generated in mouse studies to be further applied in clinical studies.

For example, by using histone deacetylase (HDAC) inhibitors, which, by remodeling chromatin structure, are thought to promote gene expression broadly, including for SMN2, numerous groups showed that they could increase SMN protein levels — both truncated and full - length — in mouse models of SMA as well as in patient - derived cell lines.

The researchers then used a technique called mass spectrometry to track the increase of heavy nitrogen in GFAP protein in the mice.

A transformative technology such as the daughterless mouse project has the potential to rapidly increase global food production, reduce the use of rodenticides, improve human health and protect biodiversity around the world.

Using the two computer equipment, the team found that the knockout mice have seven genes that are vital to the increase and decrease of sleep duration.

Using AI and Computer Vision Techniques to Determine Age and Assess the Effect of Therapies Against Aging in Mice, Increasing the Pace of Research.

For that purpose, 21 - to 23 - month - old mice were treated with daily injections of either recombinant GDF11 (rGDF11, 0.1 mg / kg mouse body weight), a dosing regimen that increases GDF11 levels in old mice toward youthful levels (13), or phosphate - buffered saline (PBS)(vehicle) for 4 weeks, and their blood vessels were subsequently analyzed by using the volumetric assay described above.

A small study using mice as subjects found some evidence that coconut oil was effective in repairing cells and increasing antioxidants following the experience of stress.

Furthermore, CBD and another component of marijuana, tetrahydrocannabivarin (THCV), may reduce body weight, as animal models of obesity using overweight mice have shown THCV to increase metabolism of fat cells.

Still other research revealed that mice eating food laced with the artificial sweetener aspartame (commonly used to sweeten diet soda) had higher blood sugar levels than mice eating food without it, which suggests it may increase your risk of diabetes and metabolic syndrome.7 Plus, whether diet or regular, most soda contains many of the following toxic elements:

Let's look first at the dosing of AMH (0.12 mg / 100g / D) used on the mice in this study to see if this matches up with the increased amount found in women with PCOS in pregnancy.

And of course you don't have to grab the mouse, you can get everything done without the use of the mouse which saves you time and increases productivity.

Activity through play is most effective with obese cats as, in addition to burning calories, it increases muscle mass, increases resting metabolic rate, improves mobility and mental stimulation, and often improves the cat — owner bond.10 Owners should be encouraged to increase their cat's activity level at home gradually, based on its needs, starting with 5 to 10 minutes per day of low - intensity activities for sedentary pets (e.g., walking).22 Creativity in activities, such as incorporating food - dispensing toys, placing meals in different parts of the house, and using interactive toys, laser pointers, and electronic mice can also be helpful with a long - term weight loss program.22 Any increase in physical activity is likely beneficial for a cat of any weight.

Located at the front - left edge of the mouse are another two buttons, silver in color and marked G10 and G11, both of which are used for increasing and decreasing the DPI on the fly.

While we know that we can switch between Virtual Desktops using the mouse, it becomes cumbersome as the number of Virtual Desktops increase.