Sentences with phrase «individual cell populations»

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These results could help gaining a clearer understanding of how cell populations collectively take robust decisions without individual coordination.»

Scientists could build chips containing cells from patients with specific genetic mutations, which could predict drug responses in specific populations, as well as personalized chips that predict an individual's drug response.

In order to thoroughly investigate cures for a diverse population, cell lines from a large sampling of individuals are needed.

«This strategy allows a colony to hedge its bets by enabling individual cells within a population to assume high levels of resistance while others avoid this extra work.»

«This transient resistance, distributed in varying degrees among individual cells in a population, may be the norm for many bacterial populations,» Dunlop said.

Although the new JNCI study did not analyze individual cell phone usage — preferring instead to take a broader look at the population at large — other research has examined subgroups of cell phone users to try to discern different trends among more frequent use.

In this mouse model, mutations in Kras and p53 genes resulted in the formation of individual tumor cell populations that were labeled with different colors.

Lee hopes the work will allow other researchers to investigate the effects of transfection on individual cells, not just large populations.

Therefore, adult stem cells become exhausted in aged individuals due to telomere length shortening that results in increased healing times and organ tissue degradation from inadequate cell populations.

Conservation work to defeat the disease has including removing infected individuals from the population and new research in Evolutionary Applications explains how this gives us a unique opportunity to understand how human selection alters the evolution of cancerous cells.

When an entire population is observed, rather than individual cells, the bacteria appear to develop a kind of collective memory.

Lepidoptera genetics is notorious for the fact that chromosome counts can vary between populations of the same species and occasionally even within cells from the same individual, he explains.

Microfluidic tools for precision measurements of cell migration speed reveal that migratory speed of individual cells changes stochastically from parent cells to their descendants, while the average speed of the cell population remains constant through successive generations.

In healthy individuals, MDSCs regulate immune responses and tissue repair, and the population of these cells rapidly expands during inflammation, infection and cancer.

This phenomenon, which indicates the presence of different mitochondrial DNA types in a cell or an individual, can be found in more than half of the population.

Western Pygmies I love population genetics for its ability to peer back into human history through the medium of DNA's ATCGs.One of the stars of this discipline is Sarah Tishkoff, a standout in African genetics, someone who will readily haul a centrifuge into the bush in Cameroon.Tishkoff of the University of Pennsylvania is lead author on a paper published online July 26 in Cell that details whole - genome sequencing of five individuals each from three extant hunter - gatherer groups — the Pygmies of Cameroon as well as the Hadza and the Sandawe of Tanzania.

B, Histograms of GFP and P2X3 normalized immunoreactivity of individual cells showing that whereas the P2X3 staining shows a unimodal normal distribution (mean 0.58), the GFP population is bimodal suggestive of high - expressing (mean = 0.69) and low - or nonexpressing populations (mean 0.12).

E, Histograms of GFP and FG normalized fluorescence intensity of individual cells showing bimodal distributions suggestive of a high - expressing population (mean GFP: 0.59, FG: 0.62) and a nonexpressing population (mean GFP: 0.08, FG: 0.08).

One of the most difficult things about treating the virus is that when a person is infected with HIV, it becomes part of the cellular population of that individual's immune cells, according to David Margolis, MD, professor of medicine, microbiology and immunology, and epidemiology at the UNC School of Medicine and director the UNC Cure Center and Collaboratory of AIDS Researchers for Eradication.

The center will develop new single - cell approaches that overcome limitations inherent in traditional techniques — which analyze bulk populations of cells, thereby obscuring individual cell behavior.

Dr. Sonntag studies this concept on the molecular and cellular level using a translational research approach that integrates the analysis of human material, such as postmortem brains, primary cell systems, and neural cell populations generated from patients» - or healthy individuals» - derived induced pluripotent stem cells (iPSC), or induced neurons (iNs), in combination with molecular, biochemistry, and lentivirus - mediated gene - engineering technologies.

Using white fat tissue from liposuction or weight - loss surgery, «we might purify a population of these progenitor cells from an obese individual expressing C29 with high potential to become energy - dissipating cells,» she explains.

The center also develops new approaches that overcome inherent limitations in traditional techniques, which analyze bulk populations of cells, thereby obscuring individual cell behavior.

Cells from a healthy individual can be reprogrammed to create an expandable population of healthy hiPS cCells from a healthy individual can be reprogrammed to create an expandable population of healthy hiPS cellscells.

Unlike other studies on p53, however, which target cell populations that average many cells together, Dr. Lahav developed a new approach, quantifying p53 at high temporal resolution in single cells and taking into account that «individual cell decisions are crucial in the development and treatment of cancer.»

When using the ClonTracer system, lentiviruses containing these barcodes infect the target cell population at low multiplicity of infection (MOI) such that each individual cell receives only one barcode.

Furthermore, it becomes increasingly evident that genome architecture varies significantly in individual cells and that many known features of genome folding, such as partitioning of chromosomes into topologically - associating domains, represent a population average.

High contrast images facilitate robust automatic tracking and behavioural analysis of hundreds of individual cells within heterogeneous cell populations is now possible without the need for intrusive dyes or labels, bringing unique morphological, temporal, and dynamic phenotypic data to your research.

The ClonTracer library allows a researcher to label individual members of a starting population of cells with specifc, easily read sequences that can be used to measure their clonal abundance before and after a treatment.

Profiling of populations from individual resting or TDLNs revealed significant transcriptional alterations in these cells.

In this study, we show that in elderly individuals seropositivity for human CMV leads to the development of oligoclonal populations of CMV - specific CTL that can constitute up to one - quarter of the total CD8 T cell population.

Developing novel tools to quantify gene expression in single cells As it has become increasingly apparent that gene expression in individual cells deviates significantly from the average behavior of cell populations, new methods that provide accurate integer counts of mRNA copy numbers in individual cells are needed.

The center will develop new approaches that overcome inherent limitations in traditional techniques, which analyze bulk populations of cells, thereby obscuring individual cell behavior.

However some technical challenges still need to be taken to make the technology more accessible and usable to its full potential: gaining selective and comprehensive genetic access to the neurons of interest, controlling variation in the expression of the optogenetic tools (when using viruses) and its precise localization (axon vs. presynaptic terminals), tailoring light - delivery system signals to individual cells in a population rather than the population as a whole, developing observation techniques which have the same spatial and temporal resolution as those tools... to cite only a few of them.

Through long - established collaborations in Durban and Kimberley, these studies in particular seek to define: the immune responses that are effective in control of HIV infection; the impact of HLA - mediated selection pressure on HIV at the individual and population level; the mechanisms of HIV non-pathogenicity; the nature and consequences of ontogeny of the virus - specific immune response; and finally the prospects for interventions including antiretroviral therapy, alone or in combination with broadly neutralising antibodies and / or T - cell vaccines, to achieve HIV eradication.

In parallel with cell culture, individual cells from each sort population were isolated for RT - PCR analysis.

Bioelectrical impedance vector analysis (BIVA) expresses tissue hydration status and body cell mass solely while considering the impedance vector relative to a population of healthy individuals (24); this was a valid method for detecting changes in hydration (classified as under -, normal or overhydration) and body fluid volume changes (25).

In addition, without asking officers to be conversant with the details of court rulings, it is not too much to expect that police would be familiar with the settled law that routine strip searches are inappropriate where the individual is being held for a short time in police cells, is not mingling with the general prison population, and where the police have no legitimate concerns that the individual is concealing weapons that could be used to harm themselves or others: Golden, at para. 97.