Sentences with phrase «individual cells changes»

Microfluidic tools for precision measurements of cell migration speed reveal that migratory speed of individual cells changes stochastically from parent cells to their descendants, while the average speed of the cell population remains constant through successive generations.

In the current study, the authors used single - cell RNA sequencing (RNA - Seq) to monitor how individual cells change when they are combined in a three - dimensional (3D) microenvironment.

Not exact matches

Every individual part may change and pass away, like cells in a body, but the one self goes on.

Instone - Brewer's own narrowing of the question of individual life -LRB-»... when does an embryo change from being a bundle of undifferentiated cells into a living human individual?»)

They used this novel simulation approach to build a model of a sperm cell that demonstrates cellular movement from individual dynein protein molecules in the tail all the way up to the whole cell, allowing them to observe how changes at the atomic level are reflected in larger - scale structures.

«By surveying thousands of individual cells, we were able to define the transcriptional landscape of lung - resident ILCs, observing changes in discrete subpopulations,» said Kowalczyk.

Holdcroft believes that the changes in the brain are more likely to be the result of changes in the volume of individual cells, rather than changes in the number of cells in the brain.

Stem cells are immature blood cells and, in theory, introducing the gene into them should produce a permanent change in that individual's maturing blood cells.

Unlike germline mutations, the post-zygotic genetic changes are only present in a proportion of the cells of the individual.

Building on this concept, Sushant Patkar of the University of Maryland and colleagues hypothesized that alterations in protein interaction networks in breast cancer cells may change the function of individual genes.

In sickle cell disease, individuals have two copies of a genetic mutation that produces an abnormal change in hemoglobin, the primary molecule that carries oxygen in the blood.

The specific changes included a higher frequency of antibodies that attack one's own cells, called autoantibodies; fewer immune regulatory T cells, which were also less active in these individuals; and a higher frequency of memory T follicular helper immune cells.

«While several lipid families are well - characterized at the molecular level, the total diversity and number of unique lipids in cells, how they change during cellular activation, and how they differ in individuals is unknown,» said Darley - Usmar.

The researchers showed that ABA concentration changes and waves of ABA movement could be monitored in diverse tissues and individual cells over time and in response to stress.

While for most individuals, there will be no long - term consequences, in some the infection may leave genetic scars and change the metabolism of these cells,» explained Wulf.

Lead researcher Dr Gabriella Ficz from QMUL's Barts Cancer Institute said: «It's surprising that cells from several healthy individuals are so permissive to gaining this epigenetic change and that one «hit» from an epigenetic editing tool is sufficient to set off this chain reaction of epigenetic inheritance and establish a cancer cell - like gene expression signature.»

The research, using cells from the Breast Cancer Now Tissue Bank and due to be published in Nature Communications, also shows that the epigenetic changes are inherited as long as the cell divides, and that the team's manipulations permanently and negatively affected the biology of a normal breast cell from a healthy individual.

The Tübingen group was making organotypic eye cultures and examining in vitro the changes that occur in the cells of living individuals.

Dr Annecchino added: «Ultimately, the problems in Alzheimer's result from changes in the information processing capability of networks of individual brain cells.

New information about how light energy is changed into neural signals shows how an individual photoreceptor cell of the eye registers the absorption of a single photon, or quantum of light

Rather Duesberg has also developed a novel theory about the origins of cancer, one that supposes a derangement of the chromosomes, rather than of individual genes, is the spark that ignites malignant changes in cells.

«In the future, we'll be able to study how this changes as stem cells differentiate and how decisions are made in individual developing stem cells.

Cells will be released to individual investigators after the first media change.

However, researchers have been skeptical of blood - based epigenetic studies for one main reason: While the genome is the same in any cell from the same individual, the epigenome necessarily changes from tissue to tissue.

This collaboration led to the discovery of distinct behavioral changes that occur in the motions of individual proteins on the surface of cells, thereby helping elucidate what it means for the pathway to be active or inactive.

They're working on engineering individual cells that react to changes in the environment and strengthen the soil around them, potentially making concrete - filled trenches unnecessary.

They also investigate how these interactions change in melanocytes depending on a combination of factors, including an individual's unique DNA sequence, DNA mutations that arise in a cell over time or due to environmental exposure, and the signals that are present in a cell's surrounding micro-environment.

We are developing methods to discover these changes in individuals, tumors, and even single cells, to promote early detection and treatments

Researchers here are cataloguing what makes cancer cells dangerous down at the level of individual genetic changes, how and why pathogens like malaria evolve to be more (or less) harmful and how humans adapt to those changes.

These include: a) Global Clusters that consist of a small, tight subset of genes that are co-expressed under the entire spectrum of experimental conditions; b) Time Series of gene expression profiles during successive days of standard ES cell differentiation; c) Specific Gene Classes based on hierarchical clustering of transcriptional factors and ESTs; d) Expression Waves of genes with characteristic expression profiles during ES cell differentiation, juxtaposed to waves of genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES database clusters.

A new study details the minute changes — down to the level of individual atoms — that cause a particular protein to form cell - damaging clumps associated with ALS and other diseases.

To examine the action of individual pathways in toto during ES cell differentiation, the FunGenES database was given an additional feature called «Pathway Animations» that depict dynamic changes in specific genetic, signaling or metabolic pathways viewed in time - related animations based on the KEGG annotation [44], [56].

Our cells in our bodies are constantly reproducing, nature is continually regenerating and growing, and as individuals, life causes each of us to change and evolve, providing our partners with more to discover and learn about us.

This therapy changes the constitution of each individual cell, stimulating excretion of waste products, and utilizing nutrients more efficiently and effectively.

The focus of the conference was connecting how epigenetics (cellular and physiological phenotypic trait variations that are caused by external or environmental factors that switch genes on and off and affect how cells read genes instead of being caused by changes in the DNA sequence — in other words nutrition and lifestyle choices) impact whether or not an individual actually develops a specific health issue even though they have a SNP mutation.

Bioelectrical impedance vector analysis (BIVA) expresses tissue hydration status and body cell mass solely while considering the impedance vector relative to a population of healthy individuals (24); this was a valid method for detecting changes in hydration (classified as under -, normal or overhydration) and body fluid volume changes (25).

Unfortunately, aging cells have a diminished ability to produce ATP due to changes in mitochondrial structure and function — unless we intervene or support our cellular energy production.Research indicates that mitochondrial DNA mutations begin accumulating in individuals starting in their mid-thirties which contributes to the decreased energy that so many people experience with increasing age.

We believe that this 10 - lipid phospholipid biomarker panel reflects the breakdown of neural cell membranes in those individuals destined to develop advanced moderate cognitive impairment or Alzheimer's disease and may mark the transition between preclinical states where synaptic dysfunction and early neurodegeneration give rise to subtle cognitive changes.»

For example, Alberts and coworkers (1990) supplemented individuals with 13.5 g / d of wheat - bran fiber (Dietary Fiber) for 8 weeks and analyzed rectal mucosa cell biopsies for changes in cell proliferation.

The first are those changes which supervene by reason of the conditions under which the embryonic or adult life of the individual is developing, these being influences on the body or soma and not on the germ - cells.

When lesions are multiple, they may be sufficiently characteristic to confirm the diagnosis; however, there are many simulants of warts, and a definitive diagnosis requires identification of the virus or its cytopathic effects on individual cells — a change known as koilocytic atypia or koilocytosis.

Like PCs and cell phones, electric cars and photovoltaics in particular (because they are all about technology, not «resources», and because they are consumer technologies that can be adopted by individuals) have the potential to cause disruptive radical change in a short time.