Sentences with phrase «individual gene level»

Bootscanning analysis revealed no evidence for recombination of TMAdV with other adenoviruses at either the whole - genome or individual gene level (Fig.

Alexander Wyatt says: «Despite the enormous complexity between patients at the individual gene level, when we examined the functions of affected genes, clear commonalities between groups of patients emerged.

Not exact matches

There are a wide range of reproductive strategies resulting from the competing interests at various levels of selection, that is, the level of individual genes / gene clusters, the level of the individual and the level of the population / species.

Audiometric tests performed on individuals with mutations in this gene subsequently revealed an unusually high level of diversity in hearing impairments, in terms of both severity and characteristics.

Co-senior author Professor Jennifer Nichols at the Wellcome Trust - Medical Research Council Stem Cell Institute, said: «Our data allow us to study gene activity in individual cells to an unprecedented level of precision.

Apart from age, genes accounted for about half of the difference among individuals in their level of delay discounting.

For example, some people have a particular variant of the ADH1B gene that causes an amino acid change in this enzyme, which leads to faster enzyme activity so individuals with this variant metabolize alcohol more rapidly which means that acetaldehyde levels are temporarily increased.

Increasingly local adaptation to climate is being studied at the molecular level by identifying which genes control climate adaptation and how these vary between individuals.

If these genes were highly active before vaccination, an individual would generate a high level of antibodies after vaccination, no matter the flu strain in the...

If these genes were highly active before vaccination, an individual would generate a high level of antibodies after vaccination, no matter the flu strain in the vaccine, researchers report online August 25 in Science Immunology.

This gives a very detailed map of gene activity, down to the level of individual cells.

Because of this level of variation, natural selection acts on the level of individual genes, not the whole genome.

In one species, the black snub - nosed monkey (about 2,000 individuals are found in the wild), they identified several hypoxia - related genes that allowed them to thrive in the highest altitudes (a narrow region 3,400 - 4,500 meters above sea level in a narrow region between the Yangtze and Mekong rivers within the Tibetan plateau) than any other nonhuman primate.

To achieve this level of insight will require a network ‐ based analysis of the associations among the individual genes, proteins, metabolites, intermediate phenotypes, and environmental factors that conspire to yield the pathophenotype.

As a graduate student at Oxford University in England, Sabeti developed a way to detect natural selection at the level of individual genes.

Dr. Sonntag studies this concept on the molecular and cellular level using a translational research approach that integrates the analysis of human material, such as postmortem brains, primary cell systems, and neural cell populations generated from patients» - or healthy individuals» - derived induced pluripotent stem cells (iPSC), or induced neurons (iNs), in combination with molecular, biochemistry, and lentivirus - mediated gene - engineering technologies.

Thus, interactome hubs such as NR1 may exhibit low levels of change in individual gene expression following hypoxia, but, based on analysis of interaction networks, are likely to play an important role in regulating the biologic response.

• CpG methylation status quantification PyroMark ID provides highly reproducible quantification of methylation frequencies in individual consecutive CpG sites, enabling accurate measurement of even small changes in methylation levels that are associated with deregulation of gene expression and tumorigenesis.

In the 1980s, Dr. Kaufman's experience with gene transfer and engineering led him to become a founding scientist at Genetics Institute Inc., where he engineered mammalian cells for high - level expression of therapeutic proteins, such as clotting factors that are now used to treat individuals with hemophilia.

Supplementary Fig. 36a shows the performance of the model based on the TIN measure at the tissue level, while Supplementary Fig. 36b compares the predictions based on TIN with the predictions based on gene expression at the individual level.

Their detailed analysis of the entirety of transcribed genes in more than 9,000 individual cells also revealed an unprecedented level of heterogeneity.

Variation is why each individual is unique at the level of genes and traits.

A web - based tool in which users can upload their individual SNP data and obtain predicted expression levels for the set of predictable genes across the 14 different cell types.

To directly measure the level of coordination in the expression of genes, we used highly sensitive fluorescence in situ hybridization (FISH) to count individual mRNAs of functionally related and unrelated genes within single Saccharomyces cerevisiae cells.

Our results revealed that transcript levels of temporally induced genes are highly correlated in individual cells.

Home > Press > Single - cell mRNA cytometry via sequence - specific nanoparticle clustering and trapping: Cell - to - cell variation in gene expression creates a need for techniques that can characterize expression at the level of individual cells

We are now in a position to understand and fight cancer at the level of individual genes.

At the highest level of resolution, the user can inspect the nucleotide sequence of individual genes.

It consists of careful genomic analysis, then minimal gene tweaking, followed by sustained monitoring at every level from ecosystem to individual gene.

By utilizing paired genome - wide high - throughput DNA sequencing (DNA - seq) with RNA - seq, we found that gene dosage, at the level of individual genes or chromosomal «somy» (a general term covering disomy, trisomy, tetrasomy, etc.), accounted for greater than 85 % of total gene expression variation in genes with a 2-fold or greater change in expression.

For genes having multiple probe sets in the Affymetrix microarray, the corresponding gene rectangle is divided horizontally with each line depicting the expression level of an individual probe set.

Here we show that the predominant mechanism determining transcript abundance differences (> 85 %) in Leishmania tropica is that of gene dosage at the level of individual genes or chromosomal somy.

+ / + - Homozygotes for this variant allele in the CTH gene had significantly higher plasma homocysteine levels than other genotypes in a cohort of 496 Caucasian individuals.

Individuals with the MTHFR gene variation and high homocysteine levels may also benefit from activated versions of folate, B6, and B12, such as methylated folate (also known as L -5-MTHF Folate, methylfolate, 5 - formyltetrahydrofolate or NatureFolate), Pyridoxyl -5-Phosphate (P5P), and methylcobalamin, respectively.