Sentences with phrase «individual genes function»

«This could mean that the reversal or suppression of pathological gene expression by beta blockers is somehow protective against heart failure, but it's something we would need to look into further to understand how individual genes function in the heart.»

Using a new powerful technique, the Lund researchers have now been able to analyse practically the entire methylome and measure individual gene function and expression.

The technology was just not efficient enough to try to look at individual gene function as the embryo develops.»

Not exact matches

What all these have in common is that, without any central control, individual units (genes, cells neurons or workers) respond to simple, local information, in ways that allow the whole system (cells, brains, organisms or colonies) to function: the appropriate number of units performs each activity at the appropriate time.

In individuals affected by SMA, the survival motor neuron - 1 (SMN1) gene is mutated and lacks the ability to process a key protein that helps neurons function.

«In short,» said Pandey, «epigenetic reprogramming in the brain due to early life experiences or exposure to alcohol can lead to the changes in gene functions and predispose an individual to adult psychopathology.»

In individuals affected by SMA, the spinal motor neuron - 1 (SMN1) gene is mutated and lacks the ability to process a key protein that helps muscle neurons function.

Korenberg was the early pioneer of studying these individuals with partial gene deletions as a way of gathering clues to the specific function of those genes and gene networks.

Building on this concept, Sushant Patkar of the University of Maryland and colleagues hypothesized that alterations in protein interaction networks in breast cancer cells may change the function of individual genes.

An entire PKS enzyme is the product of a number of individual genes, each of which is the blueprint for a protein with a well - defined function.

Genes regulating immunologic function impart to individual mice a characteristic scent.

«What we are trying to do is identify the function of genes and how they affect the way the individuals process information and the structure of the brain.

Using this «subdued» CRISPR / Cas9 system, the researchers were able to disrupt each of T. gondii's 8,158 genes and study their individual functions.

«Estrogen alters memory circuit function in women with gene variant: Hormone - gene interaction may underlie sex / individual differences in mental disorders.»

Alexander Wyatt says: «Despite the enormous complexity between patients at the individual gene level, when we examined the functions of affected genes, clear commonalities between groups of patients emerged.

It would be great if we could just go in and quickly manipulate individual mouse genes and study their function in health and disease, but, until recently, it just wasn't that easy.

They also want to be able to insert more subtle mutations, such as those reported in HIV - resistant individuals, which could alter cell function just enough to confer resistance but without fully deactivating the gene and impeding cell function.

Researchers make knockout mice by disrupting the function of individual genes across the animal's genome.

«The challenge is to pick these individual gene variations and to really drill down and try and understand their function both in the normal operation of the immune system and in the disease state.»

To better understand this complex tissues and its functions — and the diseases that affect it — a multicenter team led by researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital has released a census of the cells that make up the lining of the small intestine, using gene expression profiles of more than 53,000 individual cells from the mouse gut or gut organoid models.

In these studies, sequence data from several thousands of individuals is compared to find disease - associated genes where cases have a higher load of genetic variants that are likely to disturb gene function, compared to the controls.

This knowledge, which will only be rapidly obtainable in the model organisms, will allow the reduction of most of the approximately 70,000 individual genes encoded by the human genome into a much smaller number of multicomponent, core processes of known biochemical function.

In order to analyze the function of individual proteins in neuronal circuits or synaptic remodeling, researchers combine the Cre and FLP recombinases to control both knockout of a target gene and expression of a separate gene.

The microbe is particularly well suited for testing the functions of individual plant genes because bacterial DNA disrupts the genome at the point of insertion.

Most dramatically, they've employed the use of RNA interference (RNAi), a technique that can knock out the function of individual genes.

Understanding the biochemical pathways and mechanistic strategies that produce and mediate the functions of these diverse small RNAs is of great interest, as is elucidating the specific roles of individual small RNA genes, particularly miRNAs and siRNAs.

By performing a meta - analysis of rare coding variants in whole - exome sequences from 4,133 schizophrenia cases and 9,274 controls, de novo mutations in 1,077 family trios, and copy number variants from 6,882 cases and 11,255 controls, we show that individuals with schizophrenia carry a significant burden of rare, damaging variants in 3,488 genes previously identified as having a near - complete depletion of loss - of - function variants.

Future studies, including data from larger sample sizes of wild - born and geographically well - defined individuals, and full Y - chromosome sequences from bonobos, gorillas and orangutans, promise to further our understanding of population histories, male - biased behaviours, mutation processes, and the functions of Y - chromosomal genes.

Loss of function mutations in CTNNB1 have been reported in individuals with intellectual disability [MIM # 615075] associated with peripheral spasticity, microcephaly and central hypotonia, suggesting a recognisable phenotype associated with haploinsufficiency for this gene.

The mode of inheritance is unknown, but since the blue eyes can be single or a pair and an individual eye may be half - and - half, there probably are either more than one gene involved or there is regulatory DNA that influences the function of the gene (s) that cause this type of blue eye.