Sentences with phrase «individual genes of interest»

«What we decided to do was take a completely unbiased approach where instead of targeting individual genes of interest, we would express randomized guides inside of the cell,» Lu says.

Not exact matches

There are a wide range of reproductive strategies resulting from the competing interests at various levels of selection, that is, the level of individual genes / gene clusters, the level of the individual and the level of the population / species.

Evolution was not of major interest to most of these biologists, but insofar as they had a theory of it, it was a theory in terms of mutations of individual genes, carried by individual organisms and submitted to natural selection.

A year ago we started thinking, why don't we select a single family with an interesting disease and see whether studying a smaller group of related individuals makes it possible to identify the genes involved in that disease.

Understanding the biochemical pathways and mechanistic strategies that produce and mediate the functions of these diverse small RNAs is of great interest, as is elucidating the specific roles of individual small RNA genes, particularly miRNAs and siRNAs.

Besides information gathered to answer specific experimental questions, as determined by the interests of individual partners [35]--[41], the collective data offered the opportunity to search for coordinated gene expression patterns in a systematic exploration of the mouse ES transcriptome under a battery of different experimental settings, thus minimizing possible site - specific artifacts.

Specifically, we have generated clusters of transcripts that behave the same way under the entire spectrum of the sixty - seven experimental conditions; we have assembled genes in groups according to their time of expression during successive days of ES cell differentiation; we have included expression profiles of specific gene classes such as transcription regulatory factors and Expressed Sequence Tags; transcripts have been arranged in «Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic resources.

Here we are less interested in the contribution of individual genes (as important as these obviously are) but in the behavior of large genetic networks — hence the emphasis on genomics rather than genetics in our group name.

The widely used strategy of allele association investigates correlations of gene variants with phenotypes, i.e., it probes if individuals with a trait of interest carry a specific gene variant more frequently than individuals in a control group (case - control studies).

Within the framework of modern evolutionary biology, attachment theory focuses on the «gene - selfish» interest of children in receiving as much of their parents» physical as well as psychological resources as possible.5, 9 In terms of Trivers ’10 parent - offspring conflict paradigm, attachment theory focuses on the offspring's side of the conflict, and on the parent's willingness or unwillingness to invest in any particular individual offspring.