Sentences with phrase «individual genetic studies»

In addition, it's been difficult to repeat the findings from individual genetic studies — partly, researchers think, because autism is so variable and may really be many different diseases.

Not exact matches

But it has been disappointing in that the kind of genetic variation it detects has turned out to explain surprisingly little of the genetic links to most diseases... One issue of debate among researchers is whether, despite the prospect of diminishing returns, to continue with the genomewide studies, which cost many millions of dollars apiece, or switch to a new approach like decoding the entire genomes of individual patients.The unexpected impasse also affects companies that offer personal genomic information and that had assumed they could inform customers of their genetic risk for common diseases, based on researchers» discoveries...

Genetic ontology would study the development of ontologies in an individual subject and bring these ontologies, where possible, into relationship with the historical sequences of ontologies.

Such studies show that we are all walking genetic junkyards: Recent U.S. research suggests that every individual carries, on average, 313 disease - causing mutations.

The genetic admixture appeared in an individual found in Siberia, but not in the European Neanderthals also analyzed in the study.

They studied genetic data from 1,983 living individuals across Africa, Europe, Asia, Oceania, and the Americas and concluded that Neanderthals or another ancient hominid group must have interbred with our ancestors at least once, in the eastern Mediterranean, soon after humans migrated out of Africa.

The study, published in August in Nature Genetics, analyzed the genetic variations of 75,607 individuals who reported having depression, and 231,747 healthy controls.

«We don't know why only a fraction of individuals with genetic risk factors for celiac disease actually become gluten intolerant,» said Peter Green, MD, the Phyllis and Ivan Seidenberg Professor of Medicine at Columbia University Medical Center (CUMC), Director of the Celiac Disease Center at Columbia University and co-author on the study.

The largest of its kind, the study examined genetic data in 100,000 individuals including 40,000 people with a diagnosis of schizophrenia and also found that some of the genes identified as increasing risk for schizophrenia have previously been associated with other neurodevelopmental disorders, including intellectual disability and autism spectrum disorders.

Two study aims were to use novel whole - genome sequence data to (1) study possible correlations between language groups and genetic clustering, and (2) investigate the ancestral compositions of these individuals, including maternal and paternal lineages.

The authors caution that further study and replication of their results in different populations is needed to verify their model before it will be useful for individual genetic tests — or before longevity «cocktails» are created.

The research team's hunt for such age - related genetic associations involved studying more than 8 million single nucleotide polymorphisms — changes of one nucleotide for another at a particular spot in the DNA — in 2,693 individuals.

One study of autistic or schizophrenic individuals found they'd received four times as many new genetic mutations from dad as from mom.

The small tags in each ear indicate that this individual had been previously captured and genetic material was sampled as part of a study to understand the dynamics of the hybrid zone in southern California.

The study's cohort of Quebec twins, which included 223 sets of monozygotic twins (with an identical genetic code) and 332 sets of fraternal twins, made it possible to determine whether the individual differences observed in proactive and reactive aggression were due to genetic or environmental factors.

«Extremely low values in indices of genetic differentiation told us that all colonies are connected by a continuous exchange of individuals,» says Emiliano Trucchi formerly at the University of Vienna and now at the University of Ferrara, one of the coordinator of the study.

In this study, a team led by Panos N. Papapanou, DDS, PhD, professor and chair of oral, diagnostic and rehabilitation sciences at the College of Dental Medicine at CUMC, «reverse - engineered» the gene expression data to build a map of the genetic interactions that lead to periodontitis and identify individual genes that appear to have the most influence on the disease.

Studying the budding yeast Saccharomyces cerevisiae, USC's Matthew B. Taylor and Ian M. Ehrenreich found that the effects of these genetic variants can depend on four or more other variants in an individual's genome.

DNA methylation is one form of epigenetic modification being studied by scientists trying to understand how the same genetic code can produce so many different cells and tissues as well as differences between individuals as closely related as twins.

In a study published online this week in the journal Scientific Reports, researchers from Rice University's Center for Theoretical Biological Physics (CTBP) and colleagues from Tel Aviv University and Harvard Medical School show how sophisticated genetic circuits allow an individual bacterium within a colony to act on its own while also ensuring that the colony pulls together in hard times.

A landmark international study of DNA samples from 520,000 individuals worldwide — including 67,000 affected individuals — identified 22 new genetic risk factors for stroke.

In «Greater Cognitive Deficits with Sleep - Disordered Breathing among Individuals with Genetic Susceptibility to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis,» researchers report that study participants carrying the apolipoproStudy of Atherosclerosis,» researchers report that study participants carrying the apolipoprostudy participants carrying the apolipoprotein?

Dr Matthew Hurles, leader of the DDD Study and lead author from the Wellcome Sanger Institute, said: «In order to be able to give a genetic diagnosis for these children with neurodevelopmental disorders, we must first associate individual regulatory elements with specific disorders.

In the new work, researchers looked at genetic and health data on more than 100,000 individuals from previous large studies to determine whether genetic alterations that are associated with vitamin D levels predispose people to asthma, dermatitis, or high IgE levels.

And the largest genetic study of autistic children and their parents to date has located a host of new variations in autistic individuals.

In all, about 62 % of the individual differences in academic achievement — at least when it came to GCSE scores — could be attributed to genetic factors, a number similar to previous studies» findings, the team reports online today in the Proceedings of the National Academy of Sciences.

The TAGC study further enables more effective discovery of disease - causing mutations, since some genetic factors are observable in Ashkenazi individuals but essentially absent elsewhere.

Blue eyes have their hue because of a single genetic mutation that occurred fewer than 10,000 years ago in one individual and swept rapidly through the European population, according to a study published in the journal Human Genetics in January.

The researchers studied the adhesion mechanisms using detailed biochemical analyses and state - of - the - art genetic systems, combined with unique H. pylori clinical strains and biopsy - materials collected from individual patients and animals over a span of many years.

The study indicates that brain networks supporting basic psychological functions such as attention do not communicate appropriately in young individuals at genetic risk for illnesses such as schizophrenia or bipolar disorder.

Researchers studying Lupus have identified a triad relationship of one's genome or genetic background; epigenome or how genetic material is modified over a lifetime; and exposome, which refers to the environmental factors individuals are exposed to over time, says Gulati.

An international team of scientists, led by researchers from the University of Tuebingen and the Max Planck Institute for the Science of Human History in Jena, successfully recovered and analyzed ancient DNA from Egyptian mummies dating from approximately 1400 BCE to 400 CE, including the first genome - wide nuclear data from three individuals, establishing ancient Egyptian mummies as a reliable source for genetic material to study the ancient past.

Low birth weight and preterm birth appear to increase the risk of schizophrenia among individuals with a genetic condition called the 22q11.2 deletion syndrome, a new study from the Centre for Addiction and Mental Health (CAMH) shows.

Variability between individuals is typically attributed to genetic differences or exposure to different environments, but the researchers designed this study to account for these differences, using genetically identical worms in identical environments.

Two studies published in the Journal of Alzheimer's Disease indicate that some of the pathologic changes associated with Alzheimer's disease in older individuals are not apparent in young people who carry the apolipoprotein (APOE) genetic risk factor for developing the disease.

For participants in the prospective studies, the research team investigated how each individual's genetic risk score and lifestyle factors related to the incidence of heart attack, the need for procedures designed to open blocked coronary arteries, or sudden cardiac death.

The road to answering these questions may have a lot to do with specific genetic factors that vary from individual to individual, a new study in rats suggests.

The first big advance occurred in the early 1990s, when epidemiological studies revealed that 90 to 95 percent of individuals with the disorder carry a genetic marker associated with autoimmune disease — self - inflicted damage that occurs when the body mistakes its own tissues for a foreign invader and attacks them.

In addition, individual genetic variation in the overall response to physical exercise likely plays a part in the effects of exercise on adult neurogenesis but is less studied.

Such rare individuals could shed light on «what happens when parts of the genetic material are not working,» says study co-leader Richard Trembath.

Each of the genetic variants studied by the researchers is a single - nucleotide polymorphism, or SNP — a site at which the DNA code is altered by a single «letter» or nucleotide in some individuals, and where one «letter» is more commonly found in individuals with higher fracture risk.

He explains, «Our study shows, for the first time, that we can classify an individual's risk of breaking a bone much more reliably when we take genetic factors into account alongside clinical factors.

The researchers found that, when the «genetic risk score» was used with the GFRC, the correct classification of individuals as high or low fracture risk was increased by 12 % over and above that of the traditional clinical risk factors, which together correctly classify up to 80 % of the studied individuals into high and low risk categories.

The world's biggest study into an individual's genetic make - up and the risk of developing lung disease could allow scientists to more accurately «predict» — based on genes and smoking — your chance of developing COPD, a deadly disease which is the third commonest cause of death in the world.

«Despite being difficult to study, as they have no fixed abode, we should pay more attention to these bachelor males as they can potentially have a big effect on genetic diversity and therefore the survival of species with very few individuals remaining.

As Rand says, «A much higher level of study with more subjects in the cohort would be required before concluding that a genotype [an individual's particular genetic variation] is a risk factor.»

As with other genetic studies linking diseases to DNA markers, her research tends to compare populations who have one variation of a genetic marker with those who have a different variation — a comparison that has limited application to individuals.

Gonçalo Abecasis of the University of Michigan, Ann Arbor, and his colleagues used data from 10 genome - wide studies involving 36,610 individuals to look for genetic variations that correlated with fasting glucose concentrations.

As part of a new study from The University of Texas MD Anderson Cancer Center, published online this week in the journal CANCER, researchers also discovered that individuals with specific genetic mutations are more susceptible to the harmful compounds created when cooking at high temperatures.

Population genetic studies usually compare thousands of individuals, but the researchers predicted they could detect differences in a much smaller sample because of the stark contrast between the islanders» blond and dark locks.