Sentences with phrase «individual nucleotide»

As always, there was survival of the individual nucleotide complex and survival of the entity — the living earth.

Luscombe, J. Ule (2010) iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution.

Silence's specific siRNA molecules exhibit unique structural features which, irrespective of their individual nucleotide sequence, bar third parties from commercialising this type of molecule.

Called individual nucleotide resolution crosslinking immunoprecipitation (iCLIP), the technique enabled Sanford's lab to identify IGF2BP3 binding sites in several hundred RNA transcripts in two B - ALL cell lines.

In myotonic dystrophy and other related neurological disorders, the symptoms stem from repeated individual nucleotides, or «building blocks,» in the RNA in muscle tissue cells that can build up over time.

Scott D. Collins, Ph.D., University of Maine, Orono $ 850,000 (2 years) «High - speed Nanopore Gene Sequencing» Skilled in silicon fabrication methods, this group will try to fabricate a nanopore with tiny electrodes and built - in circuits that will be used in experiments that attempt to measure differences in the electron tunneling of individual nucleotides in DNA molecules.

The ENCODE maps allow researchers to inspect the chromosomes, genes, functional elements and individual nucleotides in the human genome in much the same way.»

Not exact matches

«The mean difference in leukocyte telomere length between the most active and least active subjects was 200 nucleotides (chemical structural units of DNA and RNA), which means that the most active subjects had telomeres the same length as sedentary individuals up to 10 years younger, on average.»

We present a draft sequence of the Neandertal genome composed of more than 4 billion nucleotides from three individuals.

They reveal 341 fixed substitutions (35 nonsynonymous, 173 synonymous, and 133 noncoding) between the 2014 EBOV and all previously published EBOV sequences, with an additional 55 single - nucleotide polymorphisms (SNPs; 15 nonsynonymous, 25 synonymous, and 15 noncoding), fixed within individual patients, within the West African outbreak.

The MGH investigators screened the genomes of 40 individuals with arhinia and 55 family members, from a total of 38 families, revealing rare single - nucleotide mutations within the SMCHD1 gene in 84 percent of affected individuals.

In the 7 May 2010 issue of Science, an international team of researchers presents the draft sequence of the Neandertal genome composed of over 3 billion nucleotides from three individuals.

The research team's hunt for such age - related genetic associations involved studying more than 8 million single nucleotide polymorphisms — changes of one nucleotide for another at a particular spot in the DNA — in 2,693 individuals.

Bustamante and Poznik obtained highly accurate sequencing results over a length of about 10 megabases of Y chromosome DNA (or 10 million nucleotides) for each of the 69 individuals.

Conventional analyses look for individual mutations called SNPs — single - nucleotide polymorphisms.

However, based on data now available, we see that the sequence of the 3 billion nucleotides in any individual genome is unique in comparison with the sequence of another individual's genome, while the degree of sequence similarity between the 3 billion nucleotides in any two genomes is remarkably high.

Then, in 2010, Pääbo and colleagues published a draft sequence of the Neanderthal's nuclear genome — 4 billion nucleotides — based on three individuals.

Falling well short of full genome analyses, these services scan an individual's DNA for single nucleotide polymorphisms — point mutations — that are linked to traits and diseases.

The DNA methylation revealed a much stronger link to survival than all other previously studied alterations in individual DNA building blocks (SNPs, single nucleotide polymorphisms).

HapMap is a directory of «single nucleotide polymorphisms,» or SNPs, places in the genome where differences between individuals (in the form of single chemical letters) appear in the DNA code.

Called the stairway plot, it models the frequency of single nucleotide polymorphisms (SNPs) in whole genome sequences of hundreds of individuals.

Each of the genetic variants studied by the researchers is a single - nucleotide polymorphism, or SNP — a site at which the DNA code is altered by a single «letter» or nucleotide in some individuals, and where one «letter» is more commonly found in individuals with higher fracture risk.

To find out, Craig and his colleagues developed a mathematical strategy to search the pool for DNA variants called single - nucleotide polymorphisms from a known individual.

To generate whole - genome and individual gene nucleotide phylogeny trees, all 95 fully sequenced unique adenovirus genomes were first downloaded from GenBank.

Previous genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of gene × environment interactions between regular use of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.

The term «single - nucleotide polymorphism» (SNP) refers to a single base change in DNA sequence between two individuals.

They may provide as much as three times the amount of base variation as the better - known single nucleotide polylmorphisms (SNPs), where single base pairs vary between individuals without affecting function.

A single DNA sequence is formed from a chain of four nucleotide bases and if some individuals in a population do not carry the same nucleotide at a specific position in the sequence, the variation is classified as an SNP.

After sequence read quality and damage filtering (Supplementary Fig. 4), we called per - individual consensus sequences for nucleotide positions covered by a minimum of two independent reads.

The resulting consensus sequences averaged 16,231 ± 455 bp, or 98.1 % of the complete mitochondrial genome, with the average number of reads per nucleotide position (fold - sequence coverage) ranging from 7.4 × to 117 × among the 9 individuals (Supplementary Data 1).

At the highest level of resolution, the user can inspect the nucleotide sequence of individual genes.

Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single - nucleotide polymorphisms in / near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single - nucleotide polymorphisms in / near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass.

In African individuals today, approximately 11 of every 10,000 nucleotides are heterozygous, meaning they differ between two copies of a chromosome.

They first looked for individual letters in DNA, called bases, that varied from one genome to the next, identifying about 4 million of these so - called single - nucleotide polymorphisms (SNPs).

In GWA studies many hundred thousand single nucleotide polymorphisms (SNPs) across the genome of many (often more than 1000) individuals are genotyped.