The ENCODE maps allow researchers to inspect the chromosomes, genes, functional elements and
individual nucleotides in the human genome in much the same way.»
Scott D. Collins, Ph.D., University of Maine, Orono $ 850,000 (2 years) «High - speed Nanopore Gene Sequencing» Skilled in silicon fabrication methods, this group will try to fabricate a nanopore with tiny electrodes and built - in circuits that will be used in experiments that attempt to measure differences in the electron tunneling of
individual nucleotides in DNA molecules.
Not exact matches
«The mean difference
in leukocyte telomere length between the most active and least active subjects was 200
nucleotides (chemical structural units of DNA and RNA), which means that the most active subjects had telomeres the same length as sedentary
individuals up to 10 years younger, on average.»
The MGH investigators screened the genomes of 40
individuals with arhinia and 55 family members, from a total of 38 families, revealing rare single -
nucleotide mutations within the SMCHD1 gene
in 84 percent of affected
individuals.
In the 7 May 2010 issue of Science, an international team of researchers presents the draft sequence of the Neandertal genome composed of over 3 billion
nucleotides from three
individuals.
The research team's hunt for such age - related genetic associations involved studying more than 8 million single
nucleotide polymorphisms — changes of one
nucleotide for another at a particular spot
in the DNA —
in 2,693
individuals.
However, based on data now available, we see that the sequence of the 3 billion
nucleotides in any
individual genome is unique
in comparison with the sequence of another
individual's genome, while the degree of sequence similarity between the 3 billion
nucleotides in any two genomes is remarkably high.
Then,
in 2010, Pääbo and colleagues published a draft sequence of the Neanderthal's nuclear genome — 4 billion
nucleotides — based on three
individuals.
The DNA methylation revealed a much stronger link to survival than all other previously studied alterations
in individual DNA building blocks (SNPs, single
nucleotide polymorphisms).
HapMap is a directory of «single
nucleotide polymorphisms,» or SNPs, places
in the genome where differences between
individuals (
in the form of single chemical letters) appear
in the DNA code.
Called the stairway plot, it models the frequency of single
nucleotide polymorphisms (SNPs)
in whole genome sequences of hundreds of
individuals.
In myotonic dystrophy and other related neurological disorders, the symptoms stem from repeated individual nucleotides, or «building blocks,» in the RNA in muscle tissue cells that can build up over tim
In myotonic dystrophy and other related neurological disorders, the symptoms stem from repeated
individual nucleotides, or «building blocks,»
in the RNA in muscle tissue cells that can build up over tim
in the RNA
in muscle tissue cells that can build up over tim
in muscle tissue cells that can build up over time.
Each of the genetic variants studied by the researchers is a single -
nucleotide polymorphism, or SNP — a site at which the DNA code is altered by a single «letter» or
nucleotide in some
individuals, and where one «letter» is more commonly found
in individuals with higher fracture risk.
Called
individual nucleotide resolution crosslinking immunoprecipitation (iCLIP), the technique enabled Sanford's lab to identify IGF2BP3 binding sites
in several hundred RNA transcripts
in two B - ALL cell lines.
Previous genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize
individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of gene × environment interactions between regular use of aspirin, NSAIDs, or both and single -
nucleotide polymorphisms (SNPs)
in relation to risk of colorectal cancer.
The term «single -
nucleotide polymorphism» (SNP) refers to a single base change
in DNA sequence between two
individuals.
A single DNA sequence is formed from a chain of four
nucleotide bases and if some
individuals in a population do not carry the same
nucleotide at a specific position
in the sequence, the variation is classified as an SNP.
Luscombe, J. Ule (2010) iCLIP reveals the function of hnRNP particles
in splicing at
individual nucleotide resolution.
Replication
in 63,475 (47,227 of European ancestry)
individuals from 33 cohorts for whole body lean body mass and
in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single -
nucleotide polymorphisms
in / near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single -
nucleotide polymorphisms
in / near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass.
In African
individuals today, approximately 11 of every 10,000
nucleotides are heterozygous, meaning they differ between two copies of a chromosome.
They first looked for
individual letters
in DNA, called bases, that varied from one genome to the next, identifying about 4 million of these so - called single -
nucleotide polymorphisms (SNPs).
In GWA studies many hundred thousand single
nucleotide polymorphisms (SNPs) across the genome of many (often more than 1000)
individuals are genotyped.