Sentences with phrase «individual than the genes»

External factors are likely to play a bigger part in developing the personality of an individual than the genes it inherits from its parents, suggests the study.

Not exact matches

A recent, groundbreaking study revealed that when a mother is insulin resistant, a particular gene is expressed more prominently than in insulin - sensitive individuals.

Rather than carry out conventional bulk analysis of cells, the research group examined individual cells, screening them for the presence of two critical gene mutations common in AML, known as FLT3 and NPM1.

Their analysis of more than 4,000 individual tumor cells, the largest effort to date in brain tumors, finds three developmental categories of cancer cells — one resembling neural stem cells and two characterized by sets of genes indicting paths towards differentiation.

Using a technique known as single - cell RNA sequencing, the team explored more than 65,000 individual cells that exist under normal or inflammatory conditions, looking for genes that were more active in one state or subpopulation versus another.

The Epigenetics Research group used these cells to perform genome - wide profiling across more than 20,000 individual genes in these patients.

Wu says, «Rather than looking for methylation changes at individual sites on the DNA, we looked at DNA regions or clusters on genes that might be more biologically meaningful than individual sites.

Although some research suggests that a preference for certain physical traits, such as height or muscular build, may be encoded in our genes, a new study finds it's our individual life experiences that lead us to find one face more attractive than another.

«First, there is no single road map to eusociality — the complex, cooperative social system in which animals behave more like superorganisms than individuals fending for themselves,» said Gene Robinson, a lead on the study who is a professor of entomology and director of the Carl R. Woese Institute for Genomic Biology at the University of Illinois.

By studying rare «copy number variations,» which are individual errant insertions or deletions of DNA segments (each of which occur in less than one percent of the population), researchers discovered a new cluster of genes that are affected in some autistic individuals as well as a number of mutations that were present in autistic children but not their parents.

By analyzing genetic samples for over half a million individuals as part of the GIANT research project, which aims to identify genes that regulate human body and size, researchers found more than 100 locations across the genome that play roles in various obesity traits.

That DNA includes slightly less than 21,000 protein - coding genes (some researchers once estimated we had more than 100,000 such genes); «genes» for 8800 small RNA molecules and 9600 long noncoding RNA molecules, each of which is at least 200 bases long; and 11,224 stretches of DNA that are classified as pseudogenes, «dead» genes now known to really be active in some cell types or individuals.

In 1978 Alec Jeffreys, a molecular biologist working at the University of Leicester, noticed that the DNA around a gene encoding part of the haemoglobin protein, varied between individuals much more than anyone expected.

An asexual species should adapt more quickly to a specific niche in the environment than a sexual species, because gene mixing between sexual individuals from different niches will produce maladapted hybrids that will not reliably pass on useful adaptations.

At first they could not determine more than six bases in the replica DNA, which did not provide enough unique addresses to identify individual genes in the human genome.

Using novel technologies developed at HMS, the team looked at how a single sensory experience affects gene expression in the brain by analyzing more than 114,000 individual cells in the mouse visual cortex before and after exposure to light.

Those few studies that have systematically compared individual gene sequences have shown that genes and the human genome may be much more variable than previously thought.

... When dopaminergic input comes in, [individuals with the SNPs on one gene copy] would have a chance of having more transmission» than those with two normal copies of the gene.

Most interestingly, the scientists found that individuals with a particular combination of mutations in both genes had five times the risk of developing asthma than those without.

«This means that the odds of an individual animal making it across I - 15, surviving to set up a territory, successfully breeding, and then their offspring breeding so the genes are spread throughout the population is harder to have happen naturally than one would expect.»

Rather Duesberg has also developed a novel theory about the origins of cancer, one that supposes a derangement of the chromosomes, rather than of individual genes, is the spark that ignites malignant changes in cells.

In one species, the black snub - nosed monkey (about 2,000 individuals are found in the wild), they identified several hypoxia - related genes that allowed them to thrive in the highest altitudes (a narrow region 3,400 - 4,500 meters above sea level in a narrow region between the Yangtze and Mekong rivers within the Tibetan plateau) than any other nonhuman primate.

Notably, besides patient EM, each individual set of VH genes averaged significantly more mutations than the IgG memory and GC or the primary responses (Fig.

In terms of functional groups rather than individual genes, of the 51.4 % Bt genes with COG annotations, those related to carbohydrate transport and metabolism comprised 10 % of the input library.

For example, the possibility of implanting brain chips raised more concern than gene editing because it would potentially impact individual personalities, rather than overall health.

Our guest published a historic paper less than one month ago (available here), describing the first comprehensive study of an individual, combining genomic (genome sequence), transcriptomic (genes turned on / off), proteomic (the total complement of proteins - or protein profiles), metabolomic (complete metabolic analysis), and autoantibody profiles.

Companion studies also shed light on the question of why boys are more likely to develop autism than girls, and begin to outline a network of genes whose activity is altered in the brains of individuals with autism.

For example, Brucella Bioinformatics Portal (BBP) is a web portal that allows users to search and analyze individual Brucella genes and link to more than 20 existing databases and analysis programs [4].

UC San Francisco researchers have identified cells» unique features within the developing human brain, using the latest technologies for analyzing gene activity in individual cells, and have demonstrated that large - scale cell surveys can be done much more efficiently and cheaply than was previously thought possible.

Epigenetics is the study of how genes can be switched on and off by factors in the environment or other external factors rather than an individual's DNA sequence.

To better understand this complex tissues and its functions — and the diseases that affect it — a multicenter team led by researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital has released a census of the cells that make up the lining of the small intestine, using gene expression profiles of more than 53,000 individual cells from the mouse gut or gut organoid models.

The condition is more common than muscular dystrophy and cystic fibrosis, but the development of new therapeutic concepts is hindered by the fact that unlike muscular dystrophy and cystic fibrosis, where a single mutated gene causing the disease is known, the entire human chromosome 21 (containing around 300 genes) still has to be dissected into individual gene - dose contributions to the DS symptoms.

They found that individuals with the variation on the RASGRF - 2 gene drank more frequently at the age of 16 than those with no variation on the gene.

At least 10 constructs of each individual HCC sample were sequenced and mutations appearing in more than five constructs were considered as somatic mutations of the p53 gene, not PCR - induced errors.

12/8/2008 Interactive Gene «Networks» May Predict if Leukemia is Aggressive or Slow - Growing Rather than testing for individual marker genes or proteins, researchers at the University of California, San Diego (UC San Diego) and the Moores UCSD Cancer Center have evidence that groups, or networks, of interactive genes may be more reliable in... More...

«The discovery of these genes means that we have to place more emphasis on treating diabetes in families rather than in individual patients,» added Bell.

The researchers hoped to create a cellular model to parse the effects of specific gene mutations, according to a press release, but in the process they discovered that skin cells from FOP patients were much more readily converted into iPSCs than cells from healthy individuals.

Their detailed analysis of the entirety of transcribed genes in more than 9,000 individual cells also revealed an unprecedented level of heterogeneity.

The vast differences between humans and chimpanzees are due more to changes in gene regulation than differences in individual genes themselves, researchers from Yale, the University of Chicago, and the Hall Institute in Parkville, Victoria, Australia, argue in the March 9, 2006, issue of the journal Nature.

By utilizing paired genome - wide high - throughput DNA sequencing (DNA - seq) with RNA - seq, we found that gene dosage, at the level of individual genes or chromosomal «somy» (a general term covering disomy, trisomy, tetrasomy, etc.), accounted for greater than 85 % of total gene expression variation in genes with a 2-fold or greater change in expression.

The early technology for locating de novo mutations was able to detect CNVs because these large structural changes in DNA could be seen more easily than individual genes.

Here we are less interested in the contribution of individual genes (as important as these obviously are) but in the behavior of large genetic networks — hence the emphasis on genomics rather than genetics in our group name.

+ / + - Homozygotes for this variant allele in the CTH gene had significantly higher plasma homocysteine levels than other genotypes in a cohort of 496 Caucasian individuals.

The idea of this theory is that autoimmune disease is caused by gene incompabilities, and that autistic individuals will get these more often than others, especially if one or both of the parents are non-autistic.

They found that those with particular alleles of these genes may take as much as 25 % more risk than individuals without.

Rare individuals are born with a mutation that allows them to survive and reproduce better than all the others so that this new gene eventually (over hundreds of thousands of years) becomes the new norm.

A clinically normal dog from a litter that had one or no individuals affected with hip dysplasia (which is a polygenic disorder) is expected to carry a lower amount of liability genes than a dog with a greater number of affected littermates.

In identifying a dog's liability for carrying defective genes for a polygenic disorder, the breadth of the pedigree (that is, consideration of all siblings of individuals in the pedigree) is more important than the depth of the pedigree (consideration only of parent - offspring relationships.)

This area becomes a bit more gray, because while there is a very good argument for not breeding close relatives of affected and carrier dogs, we also can not afford to eliminate all dogs in the gene pool who meet this criterion — to do so would risk further constriction of the gene pool to the point where the remaining «epilepsy - free» individuals might have higher - than - normal frequency for genes that contribute to some other genetic disorder.

The mode of inheritance is unknown, but since the blue eyes can be single or a pair and an individual eye may be half - and - half, there probably are either more than one gene involved or there is regulatory DNA that influences the function of the gene (s) that cause this type of blue eye.