Sentences with phrase «individual tumors targeted»
The new findings, says Korn, will encourage the researchers to clarify the status of 53 and p14ARF in the individual tumors targeted.
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Merck took a precision approach and targeted its medication towards patients whose tumors express the PD - L1 protein, enrolling these individuals in clinical trials.
Unlike conventional chemotherapies and radiation that indiscriminately eradicate fast - growing tissues and ravage people's bodies with side effects, new therapies specifically target tumors using tailored cells from individual patients.
Another possible application for the new machine is generating peptides that could be used as personalized cancer vaccines targeting unique proteins found in individual patients» tumors.
Little is known, however, about the metabolic pathways that drive the growth of individual glioblastoma subtypes — knowledge that is crucial for developing novel and effective targeted therapies that might improve treatment for these lethal tumors.
The study identified a multitude of events that could be selectively targeted in the context of individual pancreatic tumors.
By shedding light on subtle distinctions in tumor biology, these findings offer clues to designing more effective anticancer treatments to precisely target tumors in individual patients.
Whereas earlier, unsuccessful cancer vaccines usually targeted a single distinctive cancer protein shared among patients, these new ones contain multiple mutated proteins, or «neoantigens,» that are specific to an individual patient's tumor.
Additional studies in which we more precisely define the mechanisms of resistance and growth in an individual's tumor with genomic sequencing, and other means, will be important to maximize the ability to target all the critical pathways to achieve greater success.»
In the next decade, molecular research is going to further develop along five lines: predictive medicine, that investigates the genetic conditions predisposing to tumor risk; early molecular diagnosis; the evaluation of each patient's prognosis based on his / her genetic profile, in other words, the analysis of what kind of mutation affects the DNA of altered cells; the investigation of the individual response to drugs, based on our genetic knowledge; «smart drugs», molecules able to hit the target in a selective way, killing only the deprogrammed cells.»
My studies of cancer genomes have led to characterization of multiple pediatric and adult tumor types, to development of methods that identify and characterize changes in genomic heterogeneity, to defining acquired resistance mechanisms to targeted therapies and to designing novel, personalized vaccines for individual patients.
Physicians with the Personalized Medicine Program at The Tisch Cancer Institute have initiated a phase I proof - of - concept study, a fully personalized multipeptide therapeutic vaccine designed to target tumor - derived neoantigens for individual patients.
«We're using the whole tumor cell, and that allows us to stimulate a response that's broad, that's against multiple targets, and that's against targets that are unique to that individual patient,» Avigan said.
Understanding the genetic makeup of canine cancer tumors, and comparing their genetic makeup to those of people with cancer, will allow researchers to discover additional targeted drug therapies and the least toxic doses of those therapies that are most effective in curing the individual, whether canine or human.