Sentences with phrase «individuals with gene»

Dr. Tove Fall, lead study researcher at the Department of Medical Sciences and the Science for Life Laboratory at Uppsala University commented, «We knew already that obesity and cardiovascular disease often occur together... in this study we found that individuals with gene variants that lead to increased body - mass index also had an increased risk of heart failure and diabetes.»

In individuals with the gene, those who exercised showed greater brain activity in memory - related areas compared to sedentary individuals.

Individuals with the gene who were physically active had greater brain activity compared to individuals who were not gene carriers and physically active.

In this study we found that individuals with gene variants that lead to increased body - mass index (BMI) also had an increased risk of heart failure and diabetes.

One abnormality that really stood out, and it was present in all 15 patients: a piece of DNA that had been broken and rejoined, creating a mutated gene that had the potential to wreak havoc in the bodies of individuals with the gene.

«This report helps shed light on what can go wrong in individuals with genes that make one susceptible to autoimmune disease.

«Screening for these genes also would give these families potentially life - saving information to prevent colon cancer by encouraging individuals with the genes to increase the frequency of their colonoscopies.»

In the first study, the researchers have used technologies at the SNP&SEQ Technology Platform at SciLifeLab to compare genes from healthy dog individuals with genes from individuals with breast cancer.

Not exact matches

These genes are implicated in highly penetrant genetic disorders for which surgical or other interventions aimed at preventing or significantly reducing morbidity and mortality are available to pathogenic variant carriers.5 Identification of a pathogenic variant in one of these genes could be diagnostic of a medical condition with potential implications for an individual's medical management.

Ever hear of mendle, or genetic engineering or really anything have to do with genes and dna and how dna from two individuals helps create a third with genetic traits inherited from both sets of dna either as dominant or recessive.

The issue should be understood as «which is more important, the individual replicator (the gene), or the patterns generated by interactions of a myriad of replicators with a complex environment?»

But lest you think those who lack the «happy marriage» gene are doomed to a life of perpetual divorce, researchers suggest that these individuals are actually happier when they encounter someone with their same gene «deficiency.»

If genes determine our mating preferences, how is it that these supposedly hardwired instincts erode in line with societies» and individual's gender - egalitarianism?

«Until recently we have been looking for individual genes associated with diseases, which drug companies then target with treatments.

But it's associated with liver problems in rare individuals carrying another specific gene set.

The individuals with the rare gene mutations did not appear to differ from the larger population in any other ways, including in measures of blood pressure, body mass index and rates of diabetes.

Just as with modern Homo sapiens, the genome of a single individual can not tell us exactly what genes and traits are specific to all Denisovans.

The investigators mined genetic data from large clinical trials to find individuals with naturally occurring mutations in the NPC1L1 gene that completely shut it down.

Gene therapy, generally, has been the holy grail of gene - based therapeutics since the 1980s, with just a sprinkling of individual successes over the yeGene therapy, generally, has been the holy grail of gene - based therapeutics since the 1980s, with just a sprinkling of individual successes over the yegene - based therapeutics since the 1980s, with just a sprinkling of individual successes over the years.

The more diverse the genes of the MHC, the more effective it is at conferring disease resistance, and in a variety of animals individuals with diverse MHCs are more likely to be chosen as a sexual partner.

Brains of individuals who died with Huntington's, Parkinson's or no neurological condition were analyzed using sequencing technology that provides a data readout of the activity of all genes in the genome.

«Perhaps as many as 30 percent of schizophrenic patients may now become candidates for more precise treatment based on the individual characteristics of these four genes, with the remaining cases becoming less mysterious as we pull these groups out of the mix,» says Malaspina, the Anita Steckler and Joseph Steckler Professor in the Department of Psychiatry at NYU Langone.

The result is that individuals with the most common form of the disease have a total of three copies of all the genes in this region.

Nearly everyone with the condition is missing these same genes, although a few rare individuals retain one or more genes that most people with Williams have lost.

Working with colleagues at St. Vincent's Hospital in Sydney, Martin identified two individuals who had the characteristics of hereditary nonpolyposis colorectal cancer, which is usually caused by a mutation that inactivates one of a person's two copies of the tumor suppressor gene MLH1, but who showed no signs of mutation.

For example, individuals with variations in a gene called FTO tend to desire high - calorie foods more often and have more fat as a result.

The MGH investigators screened the genomes of 40 individuals with arhinia and 55 family members, from a total of 38 families, revealing rare single - nucleotide mutations within the SMCHD1 gene in 84 percent of affected individuals.

Individuals with one altered gene had longer telomeres, the caps on the ends of chromosomes that wear away as we get older, and appeared to be protected against diabetes, the researchers report.

The largest of its kind, the study examined genetic data in 100,000 individuals including 40,000 people with a diagnosis of schizophrenia and also found that some of the genes identified as increasing risk for schizophrenia have previously been associated with other neurodevelopmental disorders, including intellectual disability and autism spectrum disorders.

So her team conducted an analysis of the genetic data from 36,626 individuals to see which genes were associated with body fat.

Although individuals with variants in their FTO gene have almost double the risk of obesity compared with those who do not inherit the gene, «having the FTO variant doesn't mean one is destined to be fat.

Korenberg was the early pioneer of studying these individuals with partial gene deletions as a way of gathering clues to the specific function of those genes and gene networks.

While several studies in the intervening years have investigated whether particular genes were responsible for modifying HD onset, this is the first to employ genome - wide association (GWA) analysis, which scans an individual's whole genome to identify chromosomal regions containing variants that are associated with the disease traits that are being studied.

Now, two UCLA researchers have come up with a computational tool that increases the reliability of measuring how strongly genes are expressed in an individual cell, even when the cell is barely reading certain genes.

Audiometric tests performed on individuals with mutations in this gene subsequently revealed an unusually high level of diversity in hearing impairments, in terms of both severity and characteristics.

The human UFD1L gene was deleted in all 182 patients studied with 22q11 deletion, and a smaller deletion of approximately 20 kilobases that removed exons 1 to 3 ofUFD1L was found in one individual with features typical of 22q11 deletion syndrome.

Gene editing could include altering genes in one person — say to treat leukemia in one patient or make a cosmetic change — but, more controversially, it could also include making changes to the germ line that would then alter the genome for an individual's children, grandchildren and the following generations, with potentially unknown repercussions.

Using antibiotics to tamper with this complicated and little - understood population could irrevocably alter the microbial ecology in an individual and accelerate the spread of drug - resistant genes to the public at large.

We screened a total of 394 Amish research subjects for the KCNH7 mutation; 84 of these individuals carried at least one copy of the gene variant, and the lifetime incidence of bipolar spectrum disorders among them was 49 percent (41 people were affected with the disease).

«The finding that ciliome genes may be disrupted in children with Down syndrome and AVSD may indicate differences in life - time care for these individuals,» Zwick says.

By knocking out individual genes in the mouse, they can systematically discover any that have a crucial biological role, or are linked with disease.

Individuals who had a particular variation in a specific gene (platelet derived growth factor D; PDGFD) had a markedly increased risk of adrenal suppression, both in the children with asthma and adults with COPD.

To confirm and strengthen the findings, Zwick and his team are currently performing an independent study of individuals with Down syndrome, using whole genome sequencing to further delineate alterations in genes that perturb heart development in children.

Within a species, when some individuals have a trait that aids their survival — such as a blunt beak that allows them to crack open tough seed coverings — they will pass on the genes for that trait to their offspring, whereas individuals with pointed beaks will have died.

Over time, a mating population of native and non-native fish will result in only hybrid individuals with substantially reduced fitness because their genomes have been infiltrated by nonnative genes that are maladapted to the local environment.

The competition had whetted everyone's enthusiasm for the age of the gene, along with creating some anxiety about what the knowledge would mean for individual privacy.

Recent work indicates that individual T lymphocytes possess receptors that interact with both thymus - dependent antigens and MHC gene products, either independently or as associated structures.

The investigators confirmed the activity of genes at the newly identified loci by probing discarded corneal tissue from deceased individuals with and without Fuchs.

Labs have started tackling the problem with a tool called single - cell transcriptome analysis, which gives readouts of all the genes that are active in individual cells.

In a population with so few individuals, an unhealthy mutant gene will more often find itself paired with the same mutant gene in an offspring because the parents are related and of similar genetic makeup.