Dr. Barker and his colleagues show that the activity of certain «executioner» caspases (caspase - 3 and caspase - 9)
induce axonal degeneration and that their action is suppressed by a protein termed XIAP (X-linked inhibitor of apoptosis).
Not exact matches
Instead, the researchers found that dendritic, but not
axonal, varicosities could be
induced by prolonged treatment with glutamate, an excitatory neurotransmitter that is released from damaged axons.
Chen Gu and colleagues at The Ohio State University discovered that they could
induce the formation of
axonal varicosities in hippocampal neurons grown in the lab by «puffing» them with bursts of liquid from a small pipette.
In sciatic nerves of streptozotocin (STZ)-
induced diabetic rats, motor and sensory nerve conduction velocities (NCVs) and capillary density were reduced, and
axonal atrophy and demyelination were observed.
(2008) Trpv1 contributes to pressure -
induced death and disruption of
axonal transport in RGCs (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 5481).
Furthermore, CRF -
induced phosphorylation of tau protein interferes with neuronal energetics as it impairs
axonal transport of mitochondria.»