Sentences with phrase «induce cell proliferation»

«Probably, any molecule related to the nervous systems induce cell proliferation or differentiation during regeneration,» remarks Francesc Cebrià.

The robotic system, described today in Science Robotics, induced cell proliferation and lengthened part of the esophagus in a large animal by about 75 percent, while the animal remained awake and mobile.

Not exact matches

In cell culture, high expression levels of GPR161 induced proliferation of mammary epithelial cells, disrupted the acinar structures formed by these cells, and enhanced their invasive capacity.

In the majority of cases, UV damage leaves a unique mutational footprint behind and as a result unstoppable cell proliferation is induced.

«In our study, we demonstrated that alpha - KGDH, when coupled with Gcn5, induces histone succinylation and promotes tumor cell proliferation and tumor development.»

Because the epigenetic study looked at the broader genome of NK cell DNA, not just at the IL - 10 gene, Tarrio added, the researchers can now go back to the data to look for other proliferation - induced changes.

During pregnancy, the elevated blood estrogen level induces the proliferation of mammary epithelial cells, leading to the development of the mammary gland in preparation for lactation.

With this technique, CpG oligonucleotides are only internalized into B cells that recognize the specific antigen, and these cells are therefore the only ones in which TLR9 is activated to induce their proliferation and development into antibody - secreting plasma cells.

«While it was known that palbociclib stalls proliferation by inhibiting CDK4 / 6, inducing proteasomal activity may be an additional mechanism that ensures the completeness of the cell cycle arrest,» says Dr. Mikael Björklund, one of the lead authors of the study.

In initial work with cell cultures in Petri dishes, the researchers methodically ruled out the possibility that HIV / gp120 would be inducing the death of stem cells and determined instead that HIV / gp120 was acting by inhibiting stem cell proliferation.

MicroRNA - 138 inhibits hypoxia - induced proliferation of endothelial progenitor cells via inhibition of HIF - 1a - mediated MAPK and AKT signaling.

miR - 34a suppresses proliferation and induces apoptosis of human lens epithelial cells by targeting E2F3.

Human adipose tissue - derived mesenchymal stem cells induce explosive T - cell proliferation.

Matrix metalloproteinase (MMP)-9 induced by Wnt signaling increases the proliferation and migration of embryonic neural stem cells at low O2 levels.

GCP, a genistein - rich compound, inhibits proliferation and induces apoptosis in lymphoma cell lines.

«This idea fits nicely with the findings from a number of groups — that forced expression of cell cycle regulators can induce cardiomyocyte proliferation in mammals,» says Jopling.

Bartonella - induced endothelial cell proliferation is mediated by release of calcium from intracellular stores.

We also show that rapamycin and total mTOR silencing induces cell cycle arrest and apoptosis interfering with proliferation and survival pathways in ALK + ALCL.

Ionizing radiation is a potent DNA damaging agent that interacts with cellular DNA and induces lesions in the irradiated cells and prevents cell proliferation and induces cell death by apoptosis or necrosis depending on the radiation dose.

DEC1 / STRA13 is a key negative regulator of activation - induced proliferation of human B cells highly expressed in anergic cells

hASC treatment also mediated a significant preservation of insulin staining and β cell mass, boosted β cell number, and also induced β cell proliferation, while hASC - conditioned medium (hASC - CM) was also able to support mouse islet survival after dissociation in vitro.

In project on BRAF - mutant melanoma and EGFR - mutant non-small cell lung cancer, we conceived a novel drug sensitivity metric, the DIP rate, that makes it possible to incorporate drug - induced proliferation rates in predictive models of response.

STAT6 specific shRNA inhibits proliferation and induces apoptosis in colon cancer HT - 29 cells.

Social isolation prevents exercise - induced proliferation of hippocampal progenitor cells in female rats.

These JAK1 mutations provide cells with tumorigenic potential by inducing constitutive activation of the JAK - STAT pathway, which supports their autonomous proliferation.

He seeks to understand the molecular mechanisms that underlie pluripotency and the rapid proliferation of embryonic stem cells — they can become any type of cell in the body — and to identify the factors that induce reprogramming.

Inhibition of Notch signaling reduces proliferation of stem cells, induces cell death, and down - regulates non-canonical Wnt5a, suggesting that the Notch pathway contributes to maintenance and motility of the stem cells.

In normal cells, cytokine - induced activation of STAT proteins provides the stimulus for proliferation, survival, self - renewal, differentiation and functional activation.

External cues act on tyrosine kinase proteins embedded in the cell membrane to induce a cascade of signals with a vital role in regulating cell proliferation.

Results : The application of specific optimised conditions induce multiple rounds of memory B cell proliferation equally across Ig isotypes, differentiation of memory B cells to antibody secreting cells, and importantly do not alter the Ig genotype of the stimulated cells.

Trastuzumab directly inhibits the proliferation of HER2 - overexpressing breast cancer cells and induces immune - mediated killing of target cancer cells through antibody - dependent cellular cytotoxicity [20].

Its binding to DPP4 induces T - cell proliferation and NF - kappa - B activation in a T - cell receptor / CD3 - dependent manner.

Balb / c splenocytes were used as third - party responder cells assuming that these would induce the same degree of T cell proliferation in tolerant and control animals.

Tumor hypoxia is often linked to decreased survival in patients with breast cancer and has been shown to induce specific molecular changes in cells including changes that confer a more malignant phenotype such as increased proliferation (3), survival (4), invasion (5), and metastasis (6).

Conversely, few pro-apoptotic genes are expressed in ES cells (day 0; most boxes appear in green), but many are gradually induced during the differentiation process showing the exact opposite pattern from the genes involved in cell proliferation (Figure 7).

For instance, the role of LIF - gp130 - Stat3 axis in promoting ES cell proliferation is particularly well - defined [1], [3], and BMP - induced differentiation signals are inhibited by a Nanog - Smad1 protein complex [4]; crosstalk between these pathways has also been reported [5].

It has recently been reported that miR - 150 induces proliferation and suppresses apoptosis of breast cancer cells (Huang et al., 2013).

Targeting autophagy potentiates chemotherapy - induced apoptosis and proliferation inhibition in hepatocarcinoma cells.

Sunflower seeds are also a good source of selenium, which has been shown to induce DNA repair and synthesis in damaged cells, to inhibit the proliferation of cancer cells, and to induce their apoptosis, the self - destruction mechanism the body naturally produces to eliminate worn out or abnormal cells.

They also act aggressively against cancer by preventing cancer cell proliferation, inducing apoptosis — or cancer cell «suicide» — and inhibiting the formation of new blood vessels that nourish tumor growth.

Green tea reduces C - reactive protein and green tea catechins can successfully banish cancer cells, by slowing metastasis, inhibiting cell proliferation and inducing apoptosis.

Lobelia also acts as an antidepressant by hindering cell proliferation in the hippocampus and inducing dopamine release in the brain.

Selenium has been shown to induce DNA repair and synthesis in damaged cells and to inhibit the proliferation of cancer cells.

Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis.

In normal cells butyrate has been shown to induce proliferation at the crypt base, enhancing a healthy tissue turnover and maintenance.

Titled, «Aromatic - turmerone induces neural stem cell proliferation in vitro and in vivo,» German researchers evaluated the effects of this turmeric - derived compound on neural stem cells (NSCs)-- the subgroup of brain cells capable of continuous self - renewal required for brain repair.

Selenium has been shown to induce DNA repair and synthesis in damaged cells, to inhibit the proliferation of cancer cells, and to induce their apoptosis, the self - destruct sequence the body uses to eliminate worn out or abnormal cells.

Subpopulations of lymphocytes, mitogen - induced peripheral blood mononuclear cell proliferation (PBMC) and serum IgA and IgG concentrations were determined.

Professional Duties & Responsibilities Biomedical and biotechnology engineer with background in design of biomaterials, biosensors, drug delivery devices, microfrabrication, and tissue engineering Working knowledge of direct cell writing and rapid prototyping Experience fabricating nanocomposite hydrogel scaffolds Proficient in material analysis, mechanical, biochemical, and morphological testing of synthetic and biological materials Extensive experience in bio-imaging processes and procedures Specialized in mammalian, microbial, and viral cell culture Working knowledge of lab techniques and instruments including electrophoresis, chromatography, microscopy, spectroscopy, PCR, Flow cytometery, protein assay, DNA isolation techniques, polymer synthesis and characterization, and synthetic fiber production Developed strong knowledge of FDA, GLP, GMP, GCP, and GDP regulatory requirements Created biocompatible photocurable hydrogels for cell immobilization Formulated cell friendly prepolymer formulation Performed surface modification of nano - particle fillers to enhance their biocompatibility Evaluated cell and biomaterial interaction, cell growth, and proliferation Designed bench - top experiments and protocols to simulate in vivo situations Designed hydrogel based microfluidic prototypes for cell entrapment and cell culture utilizing computer - aided robotic dispenser Determined various mechanical, morphological, and transport properties of photocured hydrogels using Instron, FTIR, EDX, X-ray diffraction, DSC, TGA, and DMA Assessed biocompatibility of hydrogels and physiology of entrapped cells Evaluated intracellular and extracellular reactions of entrapped cells on spatial and temporal scales using optical, confocal, fluorescence, atomic force, and scanning electron microscopies Designed various biochemical assays Developed thermosensitive PET membranes for transdermal drug delivery application using Gamma radiation induced graft co-polymerization of N - isopropyl acylamide and Acrylic acid Characterized grafted co-polymer using various polymer characterization techniques Manipulated lower critical solution temperature of grafted thermosensitive co-polymer Loaded antibiotic on grafted co-polymer and determined drug release profile with temperature Determined biomechanical and biochemical properties of biological gels isolated from marine organisms Analyzed morphological and mechanical properties of metal coated yarns using SEM and Instron Performed analytical work on pharmaceutical formulations using gas and high performance liquid chromatography Performed market research and analysis for medical textile company Developed and implement comprehensive marketing and sales campaign