In the studies led by Kanneganti, Kuriakose and colleagues first sought to identify the specific machinery that the innate immune system uses to
induce cell suicide.
The cell nuclei become fragmented, and some cells will even undergo apoptosis — auto -
induced cell suicide.
Not exact matches
Their paper, which appears in Nature Communications, describes how an immune
cell recruited to the tumor
induces the programmed
suicide, or apoptosis, of the killer T
cells harnessed by many immunotherapies.
So alpha - lac may
induce apoptosis by directly causing the destruction of DNA from within the
cell's nucleus, or it may instigate the
suicide - generating caspace cascade through the mitochondria.
Discerning the basic mechanism wasn't enough — Svanborg wanted to find out if the
cells might be
induced to commit
suicide on demand: Could the discovery be developed into a cancer cure?
This protein stops potentially precancerous
cells from dividing and
induces suicide in those that are damaged beyond repair.
The scientists discovered that dinaciclib, by interfering with UPR activation, caused multiple myeloma and myeloid leukemia
cells to initiate a form of
cell suicide known as apoptosis when exposed to agents that
induced ER stress.
Plant defenses — which can include
induced cell fortification,
cell suicide, toxic chemicals, and defensive enzymes and proteins — typically were sufficient to keep the infection in check, but not strong enough to eliminate it.
Some researchers, for instance, have suggested that the AIDS virus may kill CD4
cells by
inducing them to commit
suicide.
By providing an exogenous apoptotic gene, which is only transiently expressed in
cells that already have the p16 gene active, we can precisely
induce the senescent
cell to commit
suicide.
This piquantly - flavored spice has a secret weapon: the ability to target cancer
cells and
induce them to commit
suicide — all without harming healthy
cells.
They also act aggressively against cancer by preventing cancer
cell proliferation,
inducing apoptosis — or cancer
cell «
suicide» — and inhibiting the formation of new blood vessels that nourish tumor growth.
In a 2013 study, researchers had found that quercetin inhibited the growth of pancreatic cancer
cells by
inducing apoptosis, or «
cell suicide.»