Sentences with phrase «induce high accumulation»

Not exact matches

(6) Following this initial test of abrogating the early, age - related rise in p16Ink4a - expressing cell burden, the investigators probed the effects of leaving BubR1H / H; INK - ATTAC to undergo 5 months of rapid «premature aging» (and thus, to the attendant accumulation of high levels of p16Ink4a - positive cells and onset of «early - aging» phenotypes), and only then inducing ablation of senescent cells with the INK - ATTAC drug - activated system (see Figure 2 (g) below).

Functionally, SGBS adipocytes displayed higher ISO - induced basal leak respiration and overall oxygen consumption rate, along with increased triglyceride accumulation and insulin - stimulated glucose uptake.

Several researchers have proposed that exercise - induced metabolic stress may in fact confer such an anabolic effect and some have even suggested that metabolite accumulation may be more important than high force development in optimizing muscle growth.