Sentences with phrase «induce human stem»

Exosomes had not previously been studied as a way to induce human stem cell differentiation.

Not exact matches

A few weeks ago we all heard the announcement of a major scientific breakthrough that allowed scientists to create the equivalent of human embryonic stem cells (called induced pluripotent stem cells) but without using or destroying embryos.

We referred to the news that these cells, called induced pluripotent stem cells (iPSCs), could be made from human skin....

To make the HSCs, the Harvard group used human skin cells to create induced pluripotent stem cells (iPSCs), adult cells researchers genetically reprogram to an embryonic - stem - cell state, where they can grow into any kind of cell.

Anand and his colleague Susan McKay started with human skin cells, which they turned into induced pluripotent stem cells (iPSCs) using a tried - and - tested method.

«Today's findings exemplify the many advances we've made in using CRISPR - Cas9 and human induced pluripotent stem cell technologies and the amazing discoveries that have resulted,» said Hideyuki Okano, MD, PhD, of the Keio University School of Medicine in Tokyo, Japan.

Previous research shows human induced pluripotent stem cells (hiPSCs)-- generated directly from adult cells — can express markers for a wide variety of cells, including those that secrete NP.

Several studies have supported a role for cancer stem cells in the aggressive brain tumors called glioblastoma, but those studies involved inducing human tumors to grow in mice, and as such their relevance to cancer in humans has been questioned.

Scientists headed by Dr. Stevens Rehen differentiated human induced pluripotent stem (iPS) cells into neural stem cells and into further complex tridimensional structures, known as neurospheres and brain organoids.

By promoting DNA demethylation, high - dose vitamin C treatment induced stem cells to mature, and also suppressed the growth of leukemia cancer stem cells from human patients implanted in mice.

The researchers reprogrammed the cells to create induced pluripotent stem cells in an FDA - compliant facility at the Broad Stem Cell Research Center; the use of this facility is an important step in the process as preclinical research moves toward human clinical tristem cells in an FDA - compliant facility at the Broad Stem Cell Research Center; the use of this facility is an important step in the process as preclinical research moves toward human clinical triStem Cell Research Center; the use of this facility is an important step in the process as preclinical research moves toward human clinical trials.

We don't need to use a cocktail of small molecules, growth factors or other supplements to create a population of bone cells from human pluripotent stem cells like induced pluripotent stem cells,» Varghese said.

Investigators at Johns Hopkins report they have developed human induced - pluripotent stem cells (iPSCs) capable of repairing damaged retinal vascular tissue in mice.

First produced only in the past decade, human induced pluripotent stem cells (iPSCs) are capable of developing into many or even all human cell types.

Tufts University biomedical engineers recently published the first report of a promising new way to induce human mesenchymal stem cells (or hMSCs, which are derived from bone marrow) to differentiate into neuron - like cells: treating them with exosomes.

More recently, researchers have induced stem cells from diseased human somatic cells, which may serve as new model systems for various illnesses.

In the new study, the researchers instead started with human induced pluripotent stem cells.

In fact, recent breakthroughs in the creation of human induced pluripotent stem cells (IPS) and the engineering of biodegradable scaffolds to create tissues may ultimately be applicable to most health conditions known to humankind.

«Scientists turn human induced pluripotent stem cells into lung cells: «Bronchospheres» may pave way for personalized cystic fibrosis treatments.»

But with humans, she is using iPS cells and has been working to develop the correct protocols to induce her stem cells to differentiate into different kinds of lung tissue.

Shah and his team induced toxin resistance in human neural stem cells and subsequently engineered them to produce targeted toxins.

Attrition of novel drug candidates due to cardiovascular liabilities (including proarrhythmic risk due to delayed ventricular repolarization and Torsades - de-Pointes arrhythmia) remains a hurdle for drug discovery efforts, a hurdle which may be mitigated by the use of human induced pluripotent stem - cell derived (hiPSC)- cardiomyocytes.

These stem cells — known as induced pluripotent stem cells or iPS cells — can be turned into almost any specialised cell type of the human body, including the cells we need to see.

Finally, they demonstrated that zebrafish OPCs differentiate into mature oligodendrocytes when cultured together with human motor neurons, differentiated from induced pluripotent stem cells.

Alternative cell lines, such as induced pluripotent stem cells generated from patient skin cells, offer a more accurate window on human biology, he says.

This latest study reports the generation of multiple cell lineages of the eye, including the lens, cornea, and conjunctiva, using human induced pluripotent stem cells.

Opponents have argued that the law should be rescinded since embryonic stem cells can now be generated from induced pluripotent stem cells, a technique that does not involve human embryos.

The study carried out at the University of Eastern Finland used the induced pluripotent stem cell technology, which enables the generation of pluripotent stem cells from human skin fibroblasts.

To address these limitations, investigators from Japan developed a strategy to derive functional platelets from human induced pluripotent stem cells.

Conklin's lab at Gladstone, an independent, nonprofit life science research organization affiliated with UC San Francisco, supplied these human induced pluripotent stem cells for this study.

Nakauchi's project is proceeding with colleagues at the University of California, Davis, and at Stanford, where they have injected human induced pluripotent stem cells into sheep embryos.

So - called induced pluripotent stem (iPS) cells, which are derived from adult human tissue, have the added advantage of producing tissues and organs genetically matched to a recipient, avoiding the problem of immune system rejection.

The study, published in Proceedings of the National Academy of Sciences (PNAS), utilized human induced pluripotent stem cells (hiPS cells) to map lithium's response pathway, enabling the larger pathogenesis of bipolar disorder to be identified.

«We used human skin cells that we obtained from patients affected with ALS and converted them into neurons via a technology called induced pluripotent stem cell production,» she explains.

Using a process called cellular reprogramming, the researchers take a patient's skin cells, convert them into so - called induced pluripotent stem (iPS) cells, which can differentiate into all the cells within the human body.

The LCSB scientists worked with so - called induced pluripotent stem cells — stem cells that can not produce a complete organism, but which can be transformed into all cell types of the human body.

Researchers at the RIKEN Center for Developmental Biology in Japan have succeeded in inducing human embryonic stem cells to self - organize into a three - dimensional structure similar to the cerebellum, providing tantalizing clues in the quest to recreate neural structures in the laboratory.

When BMP protein was added for three days in human pluripotent stem cell - derived gut tube cultures, it induced a posterior HOX code.

To form axon fascicles, the research teams manufactured a microdevice in which human neurons derived from induced pluripotent stem cells were injected.

Motor nerve - like tissue (right) was generated using human induced pluripotent stem cell - derived motor neurons (left).

US scientists have successfully generated hypothalamic - like neurons from human induced pluripotent stem cells (hiPSCs) taken from the blood and skin cells of super-obese individuals and people with a normal body weight.

Human embryonic stem cells derived from affected embryos during a pre-implantation diagnostic (PGD), as well as the conversion of somatic cells, such as skin fibroblasts, into induced pluripotent stem cells by genetic manipulation, offer the unique opportunity to have access to a large spectrum of disease - specific cell models.

Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice.

Neuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells.

Scientists in the lab have successfully generated neural stem cells (NCS) from human embryonic stem cells and human induced pluripotent stem cells (these are stem cells that have been reprogrammed from adult cells).

Dr. Sonntag studies this concept on the molecular and cellular level using a translational research approach that integrates the analysis of human material, such as postmortem brains, primary cell systems, and neural cell populations generated from patients» - or healthy individuals» - derived induced pluripotent stem cells (iPSC), or induced neurons (iNs), in combination with molecular, biochemistry, and lentivirus - mediated gene - engineering technologies.

Patent explosion Meanwhile, science is rapidly advancing in the field of creating induced pluripotent cells, which like human embryonic stem cells can be manipulated to form other cells.

Exosome Derived From Human Umbilical Cord Mesenchymal Stem Cell Mediates MiR - 181c Attenuating Burn - induced Excessive Inflammation.

Human pluripotent stem cells from two sources today, one physiological embryonic stem cells «ES» from the embryo, and the other experimental cells «iPS» induced pluripotency by reprogramming genetic somatic cells.

Human - induced pluripotent stem (iPS) cells can be directed to develop into light - sensing photoreceptor cells of the retina.