Sentences with phrase «induce organ damage»

During chronic inflammation, this immune response gets out of control and can induce organ damage.

FOA encourages applications that propose to conduct mechanistic studies of the circadian rhythms involved in alcohol - induced organ damage.

Furthermore l - valine may help to treat gallbladder and liver disease, including alcohol and drug abuse induced organ damage.

Not exact matches

In Cooper's case, his lungs were seriously damaged when doctors induced a coma and put him into therapeutic hypothermia after the treadmill incident to minimize damage to his organs.

They found that spaceflight appeared to activate specialized liver cells that may go on to induce scarring and cause long - term damage to the organ.

The L - arginine - induced pancreatitis is widely used as a relevant model for pre-clinical trials because 1) it is reproducible, 2) it shows dose and time dependent acinar cell necrosis, 3) it can be used for investigation of early as well as late phase of acute pancreatitis, and 4) it is suitable for investigation of extra-pancreatic organ damage (pulmonary, hepatic renal and circulatory) and insulo - acinar axis [3].

Abolition of hypertension - induced end - organ damage by androgen receptor blockade in transgenic rats harboring the mouse ren - 2 gene

Despite the protection offered by the cellular environment, the integrity of DNA is continuously challenged by a variety of endogenous and exogenous agents (e.g. ultraviolet light, cigarette smoke, environmental pollution, oxidative damage, etc...) that cause DNA lesions, interfering with proper cellular functions, such as transcription, inducing premature cellular death and finally premature ageing and organs dysfunctions.

Further understanding of the DNA damage checkpoints induced by telomere dysfunction during aging will lend support to develop therapeutic approaches to slow down aging process and improve old organ functions.

Hence, the FLI focuses on the origin of the aging - induced increases in molecular damage aiming to elucidate how it contributes to impairments in stem cell function and the evolution of organ dysfunction and diseases in aging.

Its unifying character is that some combination of causal factors induces «metabolic damage,» such as leptin resistance, in a variety of organs, including the brain.