Sentences with phrase «induced at higher doses»

In contrast, p53 expression was still induced at higher doses of ActD (> 10 nM).

DNA interstrand crosslinks (ICLs) are highly toxic DNA lesions that can form endogenously but are also induced at high doses in cancer chemotherapy.

Not exact matches

Significantly, the effect of PARTICLE in limiting the time and extent of the radiation - induced increase in DNA methylation is more pronounced at lower radiation doses than at higher doses.

All doses of the malaria vaccine induced similar high levels of antibodies, with overlapping 95 % confidence intervals among the 3 malaria vaccine dose groups at all time points.

Using these orthogonal measures of cellular pathway analysis, we confirmed that HPP - 4382, in contrast to bardoxolone, did not induce significant cellular stress at high doses as measured by HSPA6 expression and that the mechanism of HPP - 4382 activity does not appear dependent on NF - B as ICAM1 expression is not induced by HPP - 4382 (data not shown).

The application of ActD at high doses (> 800 nM) is limited due to its high toxicity through acting as a transcription blocker; however at low doses (10 - 100 nM) it induces p53 expression and is not highly toxic [13, 14].

Caffeine is not recommended for heart patients because it can induce an abnormal, rapid heart rate, especially at high doses.

Licorice, at high doses... can exacerbate or induce fluid retention, raising blood pressure.

«Chocolate, especially chocolate with a high cocoa content, contains theobromine, which can be toxic to heart and can induce seizures or pancreatitis at high doses,» explains Dr. Wismer.