«Never before has PTK6 inhibition been shown to inhibit growth and
induce cell
death of ER +
breast cancer cells, including those resistant to standard treatments for this subtype such as tamoxifen,» said Hanna Irie, MD, PhD, Assistant Professor of Medicine (Hematology and Medical Oncology) and Oncological Sciences at The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, and senior author of the
cancer cells, including those resistant to standard treatments for this subtype such as tamoxifen,» said Hanna Irie, MD, PhD, Assistant Professor of Medicine (Hematology and Medical Oncology) and Oncological Sciences at The Tisch
Cancer Institute, Icahn School of Medicine at Mount Sinai, and senior author of the
Cancer Institute, Icahn School of Medicine at Mount Sinai, and senior author of the study.
The international team of researchers modeled the lifetime risk of women developing radiation -
induced breast cancer from digital screening mammography and dying from the disease compared to the number of
breast cancer deaths prevented by early detection.
AXL mediates resistance to TRAIL -
induced cell
death in esophageal adenocarcinoma (55); it remains to be determined whether ABL - mediated protection from TRAIL -
induced apoptosis in
breast cancer cells is mediated by AXL or other targets.
The study found that curcumin is able to
induce apoptosis (normal programmed cell
death) in the most resistant
breast cancer cells that lack estrogen receptors.