Sentences with phrase «induced by cancer cells»

Not exact matches

Goji's are reported to have anti-aging properties and show anti-tumor activities against various types of skin cancer cells by inhibiting tumor growth and inducing apoptosis.

Scientists from Moffitt reported in the Jan. 19 online edition of Cancer Research that nicotine induces the metastatic spread of lung cancer cells by stimulating a protein called beta - arrestiCancer Research that nicotine induces the metastatic spread of lung cancer cells by stimulating a protein called beta - arresticancer cells by stimulating a protein called beta - arrestin - 1.

The test aims to detect and prevent the progression of HPV - induced cervical cancer and other abnormalities in the female genital tract by sampling cells from the outer opening of the cervix of the uterus and the endocervix.

By promoting DNA demethylation, high - dose vitamin C treatment induced stem cells to mature, and also suppressed the growth of leukemia cancer stem cells from human patients implanted in mice.

The research suggests that a cytokine produced by inflammatory cells near a prostate tumor induces cancer cells to decrease production of a protein that blocks metastasis.

The size difference between tumor and healthy circulating DNA was initially discovered in animal tumor models created by inducing tumors with human cancer cells.

When a cancer cell dies by apoptosis, the result is a neat and tidy process where the dead cell's remains are «recycled,» not contaminating healthy cells around them, and not inducing inflammation.

A new study led by University of Kentucky researchers suggests that activating the tumor suppressor p53 in normal cells causes them to secrete Par - 4, another potent tumor suppressor protein that induces cell death in cancer cells.

Previous studies from these researchers have showed that FL118 induces cancer cell death, or apoptosis, by inhibiting expression of multiple cell - survival proteins (survivin, Mcl - 1, XIAP or cIAP2).

Recently published in the journal eLife and featured in a poster session at this year's American Association for Cancer Research (AACR) annual meeting, preclinical experiments show for the first time that PLK1 promotes the migration of prostate cancer cells by setting in motion a process that induces what is known as the epithelial - to - mesenchymal transition Cancer Research (AACR) annual meeting, preclinical experiments show for the first time that PLK1 promotes the migration of prostate cancer cells by setting in motion a process that induces what is known as the epithelial - to - mesenchymal transition cancer cells by setting in motion a process that induces what is known as the epithelial - to - mesenchymal transition (EMT).

In examining these remaining myeloma cells, the Yale team discovered a previously unidentified biologic pathway induced by the immune modulating drugs that enabled the residual cancer cells to survive and proliferate.

Knowing more about the activation process has led researchers to be able to induce greater vulnerability by cancer cells to an existing first - line treatment for cancers (mainly lung) driven by a receptor called EGFR.

«It is striking that these changes, found in many human cancers, can be induced in normal mammary epithelial cells simply by varying the stiffness or composition of the matrix surrounding them.»

«The cancer stem cells are also recovering during this gap period, induced by PGE2 released from dying cancer cells

Because digoxin and other cardiac glycosides have been shown to induce cancer cell death, the researchers concluded that infection by Zika triggered synthesis of the molecule in glioblastoma cells and that this phenomenon is probably one of the factors that lead to neuronal cell death.

«The cancer stem cells actively regrow and respond to the induced damage or apoptosis (cell death) caused by chemotherapy in between the different cycles, similar to how normal tissue stem cells respond to wound - induced damages.»

But some cancer cells have a way to avoid apoptosis that is induced by chemotherapy.

The drugs work by jamming some of cancer cells» machinery to induce cell death.

It was originally thought that ATRA was successfully treating APL by inducing cell differentiation, causing cancer cells to change into normal cells by activating the cellular retinoic acid receptors.

Using induced pluripotent stem cells (iPSCs), a team led by Mount Sinai researchers has gained new insight into genetic changes that may turn a well known anti-cancer signaling gene into a driver of risk for bone cancers, where the survival rate has not improved in 40 years despite treatment advances.

CRI presents the Coley Award to Thierry Boon, for the isolation of genes responsible for mutation - induced production of cancer antigens by T cells, and to Rolf M. Zinkernagel, for landmark discoveries about MHC restriction of T cell recognition.

Currently, she is investigating how inhibiting aldehyde dehydrogenase can kill ovarian cancer stem cells by inducing necroptosis.

Other reported effects of PPAM included inhibition of autophagy which is an important survival mechanism that protects cancer cells against stress, impairment of the unfolded protein response (UPR) induced by glucose starvation and decrease of the activity of STAT3 [72, 73].

Growth inhibition induced by antiprogestins RU - 38486, ORG - 31710, and CDB - 2914 in ovarian cancer cells involves inhibition of cyclin dependent kinase 2.

Although persistent loss of IGF - 1R expression ultimately induced cell stasis and death, both of these processes are regulated by the tumor suppressor gene p53 that is commonly mutated in human prostate cancers.

Injections of iPSC - EPCs did not however have significant effect on tumor growth or on overall survival, but transducing cells with a baculovirus expressing CD40L, a member of the TNF gene family which can induce apoptosis [6, 7], and injection into the breast cancer lung metastasis, increased levels of pro-apoptotic cytokines in lung tissues, indicating the induction of apoptosis by CD40L carried by the EPCs (See figure).

The de-repressed satellite RNAs induced damage to the chromosomes by fusing them inappropriately and breaking them in what is called genomic instability, a catastrophic event for the cell during cell division, which can lead to cancer.

AXL mediates resistance to TRAIL - induced cell death in esophageal adenocarcinoma (55); it remains to be determined whether ABL - mediated protection from TRAIL - induced apoptosis in breast cancer cells is mediated by AXL or other targets.

He is currently funded (2016 - 2021) by the National Cancer Institute to study radiation induced changes in neuron cell dendritic morphology in cancer treatment with X-rays, protons and carbon beams, and has received grants from the Department of Energy and NASA in theCancer Institute to study radiation induced changes in neuron cell dendritic morphology in cancer treatment with X-rays, protons and carbon beams, and has received grants from the Department of Energy and NASA in thecancer treatment with X-rays, protons and carbon beams, and has received grants from the Department of Energy and NASA in the past.

Follin - Arbelet V, Torgersen ML, Naderi EH, Misund K, Sundan A, Blomhoff HK Death of multiple myeloma cells induced by cAMP - signaling involves downregulation of Mcl - 1 via the JAK / STAT pathway Cancer Lett (in press) PubMed 23454584

YAP interacts with PRDM4, thereby promoting transendothelial invasion of cancer cells by inducing expression of the leukocyte ‐ specific integrin ITGB2.

Thus, we evaluated whether addition of IL - 6 could in part rescue defective osteoclastogenesis induced by conditioned medium from breast cancer cells depleted of the ABL kinases.

Expression of a constitutively active STAT5A mutant (STAT5A *) reversed the reduction in MMP1, IL - 6, and TNC abundance induced by depletion of both ABL kinases in breast cancer cells (Fig. 7, E and F, and fig.

Our data suggest that changes in the expression of genes associated with drug resistance and cancer cell «stemness», induced by treatment with MIA - 602, lead to a significant reduction in the efflux capacity of drug resistant cells.

In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.10

We found that canonical signaling by the EphB4 receptor is low in breast cancer cells and that ephrin - induced stimulation of EphB4 kinase activity inhibits breast cancer cell malignancy in culture and tumor growth in vivo (Figure 1A) through inhibition of the CRK proto - oncogene.

In this article, we present a set of tools to quantify the flow dynamics of collagen contraction, induced by cells migrating out of a multicellular cancer spheroid into a three - dimensional (3D) collagen matrix.

15 - deoxy - Δ12, 14 - prostaglandin J2 (15d - PGJ2), a prostaglandin derivative, has shown its anti-tumor activity by inducing apoptosis through reactive oxygen species (ROS)- mediated inactivation of v - akt, a murine thymoma viral oncogene homolog, (AKT) in cancer cells.

Spatiotemporal temperature distribution and cancer cell death in response to extracellular hyperthermia induced by gold nanorods.

Some of their goals include the unravelling of disease mechanisms by using nanomaterials to track cellular components and probe the chemical niche of the cells, the transformation of adult human cells into induced pluripotent stem cells and the delivery of drugs directly to immune and cancer cells.

Shiitakes, of course, contain many of the superpower health benefits of mushrooms, including reducing cholesterol levels, helping maintain healthy weight levels, boosting immunity, and even helping to fight cancer by inducing a cell cleansing process called apoptosis.

Moreover, LA prevented the prostatic hyperplasia induced by testosterone in rats, triggered apoptosis in colon cancer cells through oxidative stress and improved the sensitization of the EGFR inhibitor cetuximab in KRAS / BRAF mutated colorectal cancer cells.

Sulforaphane induces cell cycle arrest by protecting RB - E2F - 1 complex in epithelial ovarian cancer cells.

They also act aggressively against cancer by preventing cancer cell proliferation, inducing apoptosis — or cancer cell «suicide» — and inhibiting the formation of new blood vessels that nourish tumor growth.

González - Sarrías, A.; Ma, H.; Edmonds, M.E.; Seeram, N.P. Maple polyphenols, ginnalins A-C, induce S - and G2 / M - cell cycle arrest in colon and breast cancer cells mediated by decreasing cyclins A and D1 levels.

Green tea reduces C - reactive protein and green tea catechins can successfully banish cancer cells, by slowing metastasis, inhibiting cell proliferation and inducing apoptosis.

A study published in 2012 by the Journal of Biomedicine and Biotechnology states that camel milk (but not bovine milk) induced cancer cell death in HepG2 and MCF7 and oxidative stress mediated mechanisms.

It rebalances acid / alkaline in the system and may help prevent other cancers by inducing apoptosis in human skin, thyroid, gastric, liver, colon, cervical and prostate cancer cells.

In a 2013 study, researchers had found that quercetin inhibited the growth of pancreatic cancer cells by inducing apoptosis, or «cell suicide.»

Excess aminos — typically the end result of metabolic processes stimulated by the stress - induced release of adrenal hormones — will be available for use by cancer cells].