Sentences with phrase «induced cell stress»
This may be why a UK study found that athletes who consumed dark chocolate prior to exhaustive cycling experienced less exercise - induced cell stress.
http://www.athletesquarterly.com/ Not exact matches
The researchers experimented with inducing oxidative stress in a human cell line culture with and without VCOP (virgin coconut oil polyphenols) to observe how VCOP positively promoted catalase, a very important enzyme in protecting the cell from oxidative damage, and glutathione (GSH), a self - recycling antioxidant produced by the liver.
When it reaches the brain, Zika virus infects neuronal stem cells, which will generate fewer neurons, and by inducing chronic stress in the endoplasmic reticulum, it promotes apoptosis, i.e. the early death of these neuronal cells.
They showed that ZIKV infection of cortical progenitors (stem cells for cortical neurons) controlling neurogenesis triggers a stress in the endoplasmic reticulum (where some of the cellular proteins and lipids are synthetized) in the embryonic brain, inducing signals in response to incorrect protein con - formation (referred to as «unfolded protein response»).
In this research, the scientists disturbed endoplasmic reticulum function by introducing saturated fatty acids into cells to induce lipotoxic stress.
Bottom, artificially induced stress forces cells through the gaps (yellow arrow); they break free (white arrow), forming platelets.
The researchers also examined BRAF mutant melanoma cell lines, and found that BRAF inhibition induced autophagy by way of an endoplasmic reticulum (ER) stress response.
In this study, Nicchitta and his colleagues treated tissue culture cells with a stress - inducing agent called thapsigargin.
Innovative work with stem cells also provided findings that supported the theory that stress induces vulnerable cells to malfunction, the researchers reported.
Some of the genes involved help regulate the flow of ions in and out of the cells, particularly nerve cells; others code for so - called heat shock proteins that are typically induced during stress.
Writing in 2014 in the European Journal of Neuroscience, Leuner and colleagues reported that in rats with symptoms of postpartum depression (induced by stress during pregnancy, a major risk factor for postpartum depression in women), nerve cells in the nucleus accumbens atrophied and showed fewer protrusions called dendritic spines — suggesting weaker connections to surrounding nerve cells compared with healthy rats.
The scientists discovered that dinaciclib, by interfering with UPR activation, caused multiple myeloma and myeloid leukemia cells to initiate a form of cell suicide known as apoptosis when exposed to agents that induced ER stress.
«We found that fruit flies exhibit acoustic trauma effects resembling those found in vertebrates, including inducing metabolic stress in sensory cells,» Eberl says.
In a study in the journal Cell, Jorge Ruas and Maria Lindskog show how physical exercise protects the brain from stress - induced depression in mice.
«Our study revealed that one of these mechanisms involves metabolic stress - induced structural changes within liver cells that compromise their function.»
Using TransgeneOmic BAC cell lines, we can identify proteins that form non-membrane bound compartments in HeLa cells and test which stress - conditions induce their condensation.
Epizootic Hemorrhagic Disease Virus Induces and Benefits from Cell Stress, Autophagy, and Apoptosis.
Other reported effects of PPAM included inhibition of autophagy which is an important survival mechanism that protects cancer cells against stress, impairment of the unfolded protein response (UPR) induced by glucose starvation and decrease of the activity of STAT3 [72, 73].
And the new research published this week leans towards the latter: Certain anaesthetics apparently induce mutant protein aggregation in neurons and cause stress responses in those brain cells.
Changes in Bni4 localization induced by cell stress in Saccharomyces cerevisiae.
Certain anaesthetics apparently induce mutant protein aggregation in neurons and cause stress responses in those brain cells.
Ataxin - 1 Poly (Q)- induced Proteotoxic Stress and Apoptosis Are Attenuated in Neural Cells by Docosahexaenoic Acid - derived Neuroprotectin D1.
SIH — a novel lipophilic iron chelator — protects H9c2 cardiomyoblasts from oxidative stress - induced mitochondrial injury and cell death.
Highly active antiretroviral therapy drug combination induces oxidative stress and mitochondrial dysfunction in immortalized human blood — brain barrier endothelial cells.
L - Threonine induces heat shock protein expression and decreases apoptosis in heat - stressed intestinal epithelial cells.
On the one hand, it regulates progression from premalignancy to malignancy, most likely by preventing oxidative stress - induced death of HCC - initiating cells, thereby allowing such cells to accumulate multiple oncogenic mutations, while promoting their growth through mTORC1.
Mechanisms of H2O2 - induced oxidative stress in endothelial cells.
Increased free radical induced oxidative stress plays a pivotal role in pathogenesis of many diseases including obesity, T2D and AP [7, 39 - 43] leading to macromolecular damage (DNA, protein and lipids), inflammation, ER stress and necrosis of acinar cells [44].
L - arginine is a choice of molecule to induce AP as it causes dose - dependent selective necrosis of acinar cells by ROS and ER stress, also by inhibiting polyamine synthesis in acinar cells resulting in inhibition of protein metabolism [31, 32].
For her dissertation, Prerana developed several bacTRAP transgenic mouse lines to characterize molecularly distinct cortical pyramidal cell types, and focused on layer 2/3 pyramidal cell population in the prefrontal cortex that moderate stress induced depression related behavior.
Given the apoptosome's critical role in the execution of stress - induced apoptosis, these studies provide key insights into the mechanisms by which many, if not most, chemotherapeutic agents induce cell death.
Osmotic Stress Induces Rapid Activation of a Salicylic Acid - Induced Protein Kinase and a Homolog of Protein Kinase ASK1 in Tobacco Cells
Disrupted Stress Hormone Signals in Bone Cells Protect from Diet - Induced Obesity April 4, 2017 A high - calorie diet, even without a high amount of fat, causes bone loss, and both high - calorie and high - fat diets induce excessive fat gain and insulin resistance...
In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].
Osmotic stress induces rapid activation of a salicylic acid - induced protein kinase and a homolog of protein kinase ASK1 in tobacco cells.
Loss of this factor in these stem cells induced self - renewal in a HIF1α - dependent manner under steady - state as well as severe stress conditions (Singh et al., Blood, 2013).
Another is that reducing calorie intake keeps cells under a constant low level of stress, which makes them better able to cope with higher levels of stress when it comes along — similar to how the moderate stress induced by exercise can improve people's health.
In the skin, inflammation induces oxidative stress, reducing cells» ability to defend themselves from free radical damage and promoting collagen breakdown.
During the past few years, R + ALA has risen to the status of an essential supplement for bodybuilders because it can help increase lean muscle mass by protecting cells from training - induced oxidative stress and enhancing nutrient storage.
Moreover, LA prevented the prostatic hyperplasia induced by testosterone in rats, triggered apoptosis in colon cancer cells through oxidative stress and improved the sensitization of the EGFR inhibitor cetuximab in KRAS / BRAF mutated colorectal cancer cells.
One reason might be the role of fat in inducing oxidative stress and creating free radicals, which are highly reactive atoms and molecules that damage DNA and cellular walls, ultimately killing heart muscle cells.
Saturated fat causes more of those toxic breakdown products and mitochondrial dysfunction, and increases oxidative stress, free radicals, and inflammation, establishing a vicious cycle of events in which saturated fat - induced free radicals cause dysfunction in the little power plants within our muscle cells, which causes an increase in free radical production and the impairment of insulin signaling.
''... we hypothesize that repeated stress - related allostatic overload may affect brain function at three basic levels: (a) at the cellular level, it may compromise proteostasis (e.g. tau protein), organelles homeostasis, and induce epigenetic changes in neuronal DNA; (b) at the tissue level it may affect intracellular communication (synaptic contacts), number of cells (reduction of neuronal density), composition of the extracellular matrix (accumulation of amyloid plaques), and neuroinflammation; (c) at the systemic levels it may alter the brain's regulation of behavior (cognitive decline).
They produce free - radicals which then go on to induce oxidative stress in cells and tissues throughout the body, and they strain and degrade the function of the liver, one of the body's most important detoxifying mechanisms.1
A multitude of plant hormetic compunds such as polyphenols, flavanols, luteolin, apigenin, anthocyanins, and pterostilbene — these compounds actually induce a small stress response in our cells which build cellular resilience and health
Vitamin C - rich foods like berries, citrus fruits, bell peppers and kiwi also help to protect cells from free - radical damage induced by stress.
A study published in 2012 by the Journal of Biomedicine and Biotechnology states that camel milk (but not bovine milk) induced cancer cell death in HepG2 and MCF7 and oxidative stress mediated mechanisms.
For those suffering from lead or other heavy metal poisoning, a protective diet that avoids processed foods and emphasizes the central components of a nutrient - dense and antioxidant - rich WAPF - style diet is essential (see sidebar).21 Nutritional status shapes susceptibility to lead toxicity in important ways, affecting lead's intestinal absorption; its mobilization, distribution and retention in the body; and excretion.22 Because oxidative stress is a likely mechanism explaining some of lead's toxic actions, some investigators have begun to explore whether natural antioxidants and trace minerals may help mitigate lead - induced cell damage.17 Specifically, researchers in Spain found that administration of vitamins A, B6, C and E along with zinc modulated some of the negative effects of lead exposure in rat pups, confirming the influence of nutritional factors on health outcomes following lead exposure.17 Vitamin D also should be a major component of a protective diet.
Excess aminos — typically the end result of metabolic processes stimulated by the stress - induced release of adrenal hormones — will be available for use by cancer cells].
The study team discovered that GSE targets colorectal cancer through inducing oxidative stress that leads to the programmed cell death known as apoptosis.