Sentences with phrase «induced changes in the cell»

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The introduction of infant formula to babies» diets changes the infants» gut microbiome, thus affecting the response of the infant immune system to pathogens.47 - 51 A greater amount of natural - killer cells, suggesting a more mature immune system, have been found in breastfed infants than in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, in breastfed infants than in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, in tumor cells.51, 53

The bacteria Helicobacter, believed to be a cause of stomach cancer, has been shown to trigger potentially cancer - inducing epigenetic changes in gut cells.

Now we know that changes in RNA of the cumulus cells triggered by aging - induced hypoxia, are the key messengers.

In these canine cells we induced a morphological change similar to what happens in cancer progression and we have seen displayed significant alterations in the modulation of genes, called epigenetic lesions,» says Manel EstelleIn these canine cells we induced a morphological change similar to what happens in cancer progression and we have seen displayed significant alterations in the modulation of genes, called epigenetic lesions,» says Manel Estellein cancer progression and we have seen displayed significant alterations in the modulation of genes, called epigenetic lesions,» says Manel Estellein the modulation of genes, called epigenetic lesions,» says Manel Esteller.

Oral immunotherapy for peanut allergy induces early, distinct changes in immune T - cell populations that potentially may help researchers determine which people will respond well to the therapy and which immune mechanisms are involved in the response, a new study suggests.

«Potential to predict peanut allergy immunotherapy outcomes: Successful immunotherapy induces changes in immune cell subtypes.»

In addition, the KDM4 inhibitor induces a change of the molecular make - up of the cancer stem cells and drives them out of stemness.

When gold nanoparticles combine with red, blue and green glowing proteins, as in this sensor, it's possible to discern drug - induced physical and chemical changes on a cell's surface.

Researchers showed that BEZ235 reversed infection - induced metabolic changes in the cell and reduced production of new flu virus.

Although transcription factors are often the ingredients scientists use to induce stem cell fate, Dalby and Ulijn hypothesize that certain metabolites «fuel» the pathways that result in variable concentrations of transcription factors that drive these changes.

Some basic research findings are being translated into new treatments, and with the discovery of induced pluripotent stem cells in 2006, the field has seen a step - change in biological understanding that will affect the way new drugs are identified and tested and, potentially, the way cells can be generated in the lab.

The researchers theorized that the transplanted cells induced changes in neighboring cells, leading to today's view of development as a series of cell - cell interactions.

«It is striking that these changes, found in many human cancers, can be induced in normal mammary epithelial cells simply by varying the stiffness or composition of the matrix surrounding them.»

Short DNA sequences known as «PAM» (shown in yellow) enable the bacterial enzyme Cas9 to identify and degrade foreign DNA, as well as induce site - specific genetic changes in animal and plant cells.

When the researchers induced the clock cycles to shift with chemicals or slight changes in temperature, they found that the cells also varied in their adaptability to change, in keeping with the volunteers» reports of varying responses to jet lag and other disruptions.

While many types of immune cells are involved in obesity - induced inflammation, «NK cell modulations do not change any of the other immune cells,» Lee says.

Indeed, pre-treating of human cells with a compound that inhibits changes in mitochondrial morphology allows protecting the host cell from Legionella - induced changes of mitochondria and restricts bacterial infection of human cells.

In conclusion, the proteomic approach revealed that cellular stretching induced specific phosphorylation changes in chondrosarcoma cellIn conclusion, the proteomic approach revealed that cellular stretching induced specific phosphorylation changes in chondrosarcoma cellin chondrosarcoma cells.

The treatment induced changes in the synthesis of 101 proteins and ELISA analysis revealed a sixfold higher secretion of type II collagen compared to control cells.

Using induced pluripotent stem cells (iPSCs), a team led by Mount Sinai researchers has gained new insight into genetic changes that may turn a well known anti-cancer signaling gene into a driver of risk for bone cancers, where the survival rate has not improved in 40 years despite treatment advances.

Those doses were chosen in analogy with the prion field, in which it is very common to observe that 1 % and 0.1 % tissue homogenate containing prion protein aggregates is able to induce pathological changes both in cell culture experiments and in in vivo animal models.

Changes in cell junctions induced by inhibition of epidermal growth factor receptor in oral squamous cell carcinoma cells.

«We wanted to understand how a long - term high - fat diet influences the biology of stem cells, and how such diet - induced changes that occur in stem cells impact tumor initiation in the intestine,» Yilmaz says.

Changes in Bni4 localization induced by cell stress in Saccharomyces cerevisiae.

Forced expression of this SMN1 variant in cultured non-neuronal cells induces the formation of neurite - like extensions, a change in cell shape reminiscent of that occurring when motor neurons send out axons to their muscle targets.

Aromatase overexpression induces malignant changes in estrogen receptor α negative MCF - 10A cells.

His uses genome engineering methods to test the role of specific genetic changes in induced pluripotent cell (iPSC)- derived models of disease.

Reber, F., Reber, U. and Funk, R.H. Intracellular changes in astrocytes and NG 108 - 15 neuroblastoma X glioma cells induced by advanced glycation end products.

We found significant differences in overall cellular composition between pre - and post-mortem blood samples (p < 0.001), the most notable changes induced by death being an increase in resting NK cells and CD8 T - cells, and a substantial reduction in neutrophils (Fig. 7a).

Kyoto University cell biologists wanted to find out if «flipping» enzymes belonging to the P4 - ATPase family were involved in inducing cell membranes to change shape.

However, further investigations are needed to clarify whether previous metabolic influences at the level of quiescent satellite cells in vivo can induce irreversible metabolic changes in cultured human myotubes.

He is currently funded (2016 - 2021) by the National Cancer Institute to study radiation induced changes in neuron cell dendritic morphology in cancer treatment with X-rays, protons and carbon beams, and has received grants from the Department of Energy and NASA in the past.

Many, if not all, oncogenes and tumor suppressor genes induce metabolic reprogramming in cancer cells through changes in the regulation of enzymes and transporters.

Our data suggest that changes in the expression of genes associated with drug resistance and cancer cell «stemness», induced by treatment with MIA - 602, lead to a significant reduction in the efflux capacity of drug resistant cells.

Shinya Yamanaka's discovery of induced pluripotent stem (iPS) cells in 2006 fundamentally changed biomedical research.

CpG stimulation of precursor B lineage acute lymphoblastic leukemia induces a distinct change in costimulatory molecule expression and shifts allogeneic T cells towards a Th1 response.

For cell reprogramming, there are about 2,000 known transcription factors that might be useful in changing a cell from one state to another, such as creating induced pluripotent stem (iPS) cells from skin cells.

Tumor hypoxia is often linked to decreased survival in patients with breast cancer and has been shown to induce specific molecular changes in cells including changes that confer a more malignant phenotype such as increased proliferation (3), survival (4), invasion (5), and metastasis (6).

Here, we also observed little change in Oct4 mRNA levels following DMSO - induced differentiation, and we show that the transcript is present in differentiated, non-proliferative cells (Figure 1B).

Persistent inflammation induced by prolonged or repetitive exposure to specific allergens, typically characterized not only by the presence of large numbers of innate and adaptive immune cells (in the form of leukocytes) at the affected site but also by substantial changes in the extracellular matrix and alterations in the number, phenotype and function of structural cells in the affected tissues.

''... we hypothesize that repeated stress - related allostatic overload may affect brain function at three basic levels: (a) at the cellular level, it may compromise proteostasis (e.g. tau protein), organelles homeostasis, and induce epigenetic changes in neuronal DNA; (b) at the tissue level it may affect intracellular communication (synaptic contacts), number of cells (reduction of neuronal density), composition of the extracellular matrix (accumulation of amyloid plaques), and neuroinflammation; (c) at the systemic levels it may alter the brain's regulation of behavior (cognitive decline).

Recent studies show self - induced changes in mood can increase serotonin production, positively affecting cell signaling in the body (4).

But researchers don't know what exactly is causing this shift in the Hadley cell, whether it's explicitly due to human - induced climate change and how long the shift may last.

The resemblance of the NH cents SAT patterns to the typical cell - like NAM pattern effects in the meteorological data used here and the similarity of model predictions of Rozanov et al. to the positive NAM SAT pattern perhaps indicates a common mechanism between the NAM and changes induced by geomagnetic variations.