Sentences with phrase «induced cognitive impairment»

The available data suggest that reversal of scopolamine - induced cognitive impairment is a viable model for predicting pharmacodynamic signals of cognition enhancing compounds in animals [91].

However, they found no beneficial effect of the supplemented diet on mitigating chemotherapy - induced cognitive impairments.

Importantly, these studies provide the foundation for the in vivo characterization of the mechanisms that contribute to drug - induced cognitive impairments that will greatly facilitate the design and testing of therapeutic interventions to ameliorate excessive impulsivity that sabotages attempts at prolonged drug abstinence.

A deeper understanding of the pre-plaque stage is of great relevance in view of the fact that the intraneuronal compartment is also a place where Aβ can oligomerize [10, 21, 22] forming toxic aggregates which can impair synaptic plasticity [23 — 26], induce cognitive impairments [27, 28] and unleash a pro-inflammatory reaction [10, 29].

Not exact matches

The work also helps to determine the fine line between experience - induced changes in the brain and differences that are the cause of cognitive impairment.

The ambitious goal: to learn to identify early signs of trauma - induced brain damage from subtle changes in blood chemistry, brain imaging, and performance tests — changes that may show up decades before visible symptoms such as cognitive impairment, depression, and impulsive behavior.

The acetylcholinesterase inhibitor, donepezil, which transiently improves cognition in AD, reverses the cognitive impairment induced by scopolamine in both humans and animals [92, 93].

Abstract: Diabetes - associated cognitive decline (DACD) is a brain injury induced by diabetes mellitus, with cognitive impairment as the major symptom.

An earlier pilot study showed a high correlation between MCT - induced ketosis and improved cognition in mild cognitive impairment (Rebello et al., 2015).

As sleep loss induces significant safety impairments in cognitive performance equivalent to alcohol intoxication, we do not believe that experimentally induced sleep loss outside of a controlled laboratory environment is safe.

Amyloid - beta / fyn - induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of alzheimer's disease.

In addition, alcohol - induced impairments such as falling and visual and cognitive problems could be exaggerated in older people.

These toxic stress - induced changes in brain structure and function mediate, at least in part, the well - described relationship between adversity and altered life - course trajectories (see Fig 1).4, 6 A hyper - responsive or chronically activated stress response contributes to the inflammation and changes in immune function that are seen in those chronic, noncommunicable diseases often associated with childhood adversity, like chronic obstructive pulmonary disease (COPD), cirrhosis, type II diabetes, depression, and cardiovascular disease.4, 6 Impairments in critical SE, language, and cognitive skills contribute to the fractured social networks often associated with childhood adversity, like school failure, poverty, divorce, homelessness, violence, and limited access to healthcare.4, 19,58 — 60 Finally, behavioral allostasis, or the adoption of potentially maladaptive behaviors to deal or cope with chronic stress, begins to explain the association between childhood adversity and unhealthy lifestyles, like alcohol, tobacco, and substance abuse, promiscuity, gambling, and obesity.4, 6,61 Taken together, these 3 general classes of altered developmental outcomes (unhealthy lifestyles, fractured social networks, and changes in immune function) contribute to the development of noncommunicable diseases and encompass many of the morbidities associated epidemiologically with childhood adversity.4, 6