Sentences with phrase «induced immune response»

Nippostrongylus brasiliensis, a nematode parasite of rodents, has a parasitic life cycle that is an extremely useful model for the study of human hookworm infection, particularly in regards to the induced immune response.

The identification of SH2D1A will allow the determination of its mechanism of action as a possible regulator of the EBV - induced immune response.

GIG's study investigated whether gluten - free and gluten - removed beers induced an immune response in blood samples from persons with celiac disease.

Treatment of male monkeys with a reproductive tract protein induces an immune response that causes reversible infertility, suggesting a potential male contraceptive.

Friedman and his team, therefore, designed their new vaccine to induce an immune response against not only gD2 but also two other viral glycoproteins, gC2 and gE2.

A recent study published in Cell revealed that, while the related parasite Tritrichomonas musculis makes the intestine susceptible to both colitis and colorectal cancer, it induces an immune response that protects mice against Salmonella infection.

Gardasil induces an immune response withan empty HPV viral envelope built from repeating shapes, much like a soccerball.

In experiments with dogs, Schlegel and Garcea have discovered that thesoccer ball doesn't have to be in one piece to induce an immune response.

Analyses of RV144 volunteers revealed that particular vaccine - induced immune responses, including production of certain antiviral antibodies and CD4 + T cell responses to HIV's outer shell, or envelope, correlate with reduced HIV infection.

Specific T cells then recognize these antigen - loaded MHC molecules and induce immune responses.

They hypothesize that the reactive particles may induce an immune response in the body or modify the biochemical signaling agents between cells.

This did induce an immune response but only led to tumor rejection in one - quarter of the animals.»

«If you immunize people with an antigen that induces an immune response against schistosomiasis, there will likely be benefits not only in controlling the immediate infection but also a means to avoid bladder cancer.»

vector - a bacterium or virus that does not cause disease in humans and is used in genetically engineered vaccines to transport genes coding for antigens into the body to induce an immune response.

We assess spontaneous and vaccine - induced immune responses against melanoma, and have a particular interest in developing methods for understanding functional subpopulations within melanoma and the optimal ways of targeting them therapeutically.

When he asked, rhetorically, if this vaccine induced immune responses against tumor neoepitopes, Coukos informed the audience «the answer is «absolutely, yes.

Through this approach, she showed in mice that vaccine - induced immune responses — which correlated with predicted MHC binding affinity and the measured peptide - MHC complex stability — were associated with positive outcomes.

This includes utilizing a modified chimpanzee virus as a vaccine carrier to induce an immune response against HIV, and a new therapeutic vaccine against human papillomavirus (HPV), a leading cause of cervical cancer.

Because hemagglutinin also happens to be the part of the flu vaccine that induces an immune response in people (it's the H in a virus name like H5N1), each mutation renders the vaccine less effective.

A key moment in her research occurred when she discovered that she could induce an immune response in mice by injecting them with an irradiated malaria parasite.

In 2010, we formally demonstrated ADE by developing a mouse mode of ADE - mediated disease, and we began to dissect the contribution of humoral vs. cellular immune components in dengue vaccine - mediated protection using model vaccine candidates as tools to probe the mechanisms by which the vaccine - induced immune responses in mice contribute to protection vs. ADE.

The same year, the FDA approved the start of the first human clinical trial of this vaccine that demonstrated its safety and efficacy at inducing an immune response against the virus.

Alterations in response profiles were related to vaccine - induced immune responses and subsequent outcome after wild - type Salmonella Typhi challenge.

The Dockrell group is examining vaccine - induced immune responses that may predict immune protection against tuberculosis (TB), and how co-infection and co-morbidity can affect such immune responses.

(14) Stress increases intestinal permeability, allowing bacteria and bacterial antigens to cross the epithelial barrier into the bloodstream, inducing an immune response that alters the microbiome.

HW - associated inflammatory mediators that induce immune responses in the lungs and kidneys (immune complex glomerulonephritis) cause vasoconstriction and possibly bronchoconstriction.

Not exact matches

In addition, the buildup of mucous in the lungs, as a result of this immune response to infection, induces coughing as a reflex to try to clear the airways.

The introduction of infant formula to babies» diets changes the infants» gut microbiome, thus affecting the response of the infant immune system to pathogens.47 - 51 A greater amount of natural - killer cells, suggesting a more mature immune system, have been found in breastfed infants than in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, 53

To investigate immune responses, the researchers injected an antigen — a derivative of a pathogen that creates an immune response without inducing illness — into the skin of 175 participants (78 were over 65 years old and the rest were under 40).

To fend off HIV, researchers introduced one vaccine (ALVAC) to induce a T cell response — thereby alerting the immune system — and another (AIDSVAX) later to spur an antibody response.

Researchers uncovered the following pathway: gut bacteria stimulate intestinal B lymphocytes to release interleukin (IL)-10 that, in turn, induces development of regulatory T lymphocytes that prevent excessive inflammatory responses and limit immune - mediated disease.

Oral immunotherapy for peanut allergy induces early, distinct changes in immune T - cell populations that potentially may help researchers determine which people will respond well to the therapy and which immune mechanisms are involved in the response, a new study suggests.

Currently, the NIAID - supported Immune Tolerance Network is conducting a randomized trial called IMPACT to determine whether peanut OIT can lower the risk of allergic reactions, induce tolerance and change the immune responses of peanut - allergic children aged 12 to 48 months.

This is believed to be why L - asparaginase induces a more moderate immune response than bacterial enzymes do.

Working with the Tulane National Primate Center in Louisiana, Friedman and his group showed that the trivalent vaccine — given three times at monthly intervals — induced a strong immune response in macaque monkeys, whose immune system closely resembles the human version.

The vaccine also induced a sharp rise in CD4 T - cells, whose job is to mobilize the antibody response and other immune elements against viral infections.

In a phase 2 trial that included nearly 1,000 adults, the AS03 and MF59 adjuvants (a component that improves immune response of inactivated influenza vaccines) increased the immune responses to two doses of an inactivated H7N9 influenza vaccine, with AS03 - adjuvanted formulations inducing the highest amount of antibody response, according to a study in the July 21 issue of JAMA.

Strains of bacterial species induce a greatly varied acute adaptive immune response: The contribution of the accessory genome.

To find out, the team genetically modified mice to block production of Nppb in TRPV1 neurons, then injected the skin on their shoulders with a range of itch - inducing compounds, including histamine, an inflammatory molecule involved in immune responses, and the malaria drug chloroquine.

This is because memory B cells, which remember antigens in the primary immune response, are induced and respond faster in the secondary exposure to bacteria or viruses and differentiate into antibody - producing cells.

The new findings explain why DCs are not effective in executing a specialized process that is required for inducing antitumor immune responses and effective cancer immunotherapy.

Dr. De Carvalho says: «Another important implication of our finding is that since decitabine induces an anti-viral response, which is highly immunogenic, it may be useful to combine this agent with immune therapy to further advance personalized cancer medicine by boosting an individual's natural defenses to fight disease.

Antigen - specific therapy using insulin before the development of autoantibodies may induce protective immune responses that prevent the emergence of autoimmunity and subsequent type 1 diabetes in genetically at - risk children, according to background information in the article.

Ezio Bonifacio, Ph.D., of the DFG Center for Regenerative Therapies Dresden, Technische Universitat Dresden, Germany and colleagues randomly assigned autoantibody - negative, genetically at - risk children to receive oral insulin at varying doses (n = 15) or placebo (n = 10) once daily for 3 to 18 months to assess whether oral insulin can induce a potentially protective immune response without causing adverse effects.

This study compared social and non-dependent problem drinkers on the impact of alcohol - related changes in the body's immune response to stress, alcohol - cue induced craving and anxiety, motivation to drink, and alcohol consumption.

The researchers found that in mice, a single injection of 30 millionths of a gram of these mRNAs — a small fraction of the dose used for a typical vaccine — induced a rapid immune response, which protected mice from intravenous exposure to a separate Zika strain two weeks later.

Future studies are needed to better define the molecular mechanism behind TREML4 - induced amplification of TLR7 signaling and to clarify beneficial reactions controlled by TREML4 — for example, the immune response to influenza virus, which the current study found was inhibited by TREML4 deficiency.

An additional mechanism to prevent the immune response from going «overboard,» the researchers conclude, is provided by a subset of T - cells called induced regulatory T - cells (iTreg cells).

To fend off HIV, researchers introduced one vaccine (ALVAC - HIV) to induce a T cell response — thereby alerting the immune system — and another (AIDSVAX B / E) later to spur an antibody response.

Historically, vaccines against viral diseases have used live - attenuated (weakened) viruses or inactivated whole viruses to induce protective immune responses.