Sentences with phrase «induced immune responses in mice»

In 2010, we formally demonstrated ADE by developing a mouse mode of ADE - mediated disease, and we began to dissect the contribution of humoral vs. cellular immune components in dengue vaccine - mediated protection using model vaccine candidates as tools to probe the mechanisms by which the vaccine - induced immune responses in mice contribute to protection vs. ADE.

A key moment in her research occurred when she discovered that she could induce an immune response in mice by injecting them with an irradiated malaria parasite.

Not exact matches

To find out, the team genetically modified mice to block production of Nppb in TRPV1 neurons, then injected the skin on their shoulders with a range of itch - inducing compounds, including histamine, an inflammatory molecule involved in immune responses, and the malaria drug chloroquine.

A recent study published in Cell revealed that, while the related parasite Tritrichomonas musculis makes the intestine susceptible to both colitis and colorectal cancer, it induces an immune response that protects mice against Salmonella infection.

The researchers found that in mice, a single injection of 30 millionths of a gram of these mRNAs — a small fraction of the dose used for a typical vaccine — induced a rapid immune response, which protected mice from intravenous exposure to a separate Zika strain two weeks later.

We find that a single administration of the MN patch induces robust immune responses in a B16F10 mouse melanoma model compared to MN without degradation trigger or intratumoral injection of free aPD1 with the same dose.

Through this approach, she showed in mice that vaccine - induced immune responses — which correlated with predicted MHC binding affinity and the measured peptide - MHC complex stability — were associated with positive outcomes.