Sentences with phrase «induced immunopathologies»

Systemic perspectives on the organism and organ level address fundamental questions of infection biology and shall contribute to reveal the molecular underpinnings of virus - induced immunopathologies and other inflammatory diseases.

Thus, all four vaccines evaluated induced the immunopathology; however, all four also induced neutralizing antibody and protection against infection when compared to control challenged animals.

In later experiments, these findings were confirmed and the vaccine utilized by Haagmans, et al. was also shown to induce the immunopathology in mice.

Not exact matches

In an effort to determine whether an adjuvant that induced a bias for a Th1 - type response would protect and prevent the immunopathology, we initiated an experiment where the DI PBS suspended vaccine was adjuvanted with Freund's complete adjuvant, a Th1 - type adjuvant.

However, challenge of mice given any of the vaccines led to occurrence of Th2 - type immunopathology suggesting hypersensitivity to SARS - CoV components was induced.

As indicated, strong animal model evidence indicates expression of the N protein by SARS - CoV vector vaccines can induce sensitization leading to a Th2 — type immunopathology with infection.

To be certain the Th2 type immunopathology was elicited by the S protein vaccine in our studies and in hopes a greater immune response would result from higher dosages of the vaccine and induce greater protection against infection as well as reduce or prevent the immunopathology, our experiment 2 used up to 9 µg of the S protein for immunization.

While increased titers of serum antibody were induced and no virus was detected day two after challenge in most animals, the Th2 - type immunopathology occurred after challenge, and the immunopathology seen earlier after vaccination with the DI whole virus vaccine was seen again.