«It was really surprizing to realize that oncogenic Pik3ca
in basal
cells induced the formation of luminal
tumours, while its expression
in luminal
cells gave rise to heterogeneous and more aggressive tumors including basal - like tumors,» comments Alexandra Van Keymeulen, the first author of the paper.
Molecular characterization of the
cells that undergo
cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene -
induced reprogramming of these newly formed
cells and identified gene expression signatures, characteristic of the different
cell fate switches, which was predictive of the cancer
cell of origin,
tumour type and clinical outcomes
in women with breast cancers.
The researchers found much higher levels of heparanase
in childhood brain
tumours than
in the normal brain, and furthermore, a molecule that can block this enzyme
induces cell death
in medulloblastoma
cells in culture, while normal brain
cells were not affected.