«Although an association between exercise -
induced irisin and body composition change was found in obese adults, we could not evaluate their causal relationship in this study.
Therefore, future study should cover the role of exercise -
induced irisin on body composition including muscle mass and fat mass.»
«Exercise -
induced irisin may not only act as an endocrine factor capable of promoting the browning of white adipose tissue, but could also regulate bone metabolism by autocrine mechanisms,» said Chen, who also serves as faculty in the Cell, Molecular & Developmental Biology program at the Sackler School of Graduate Biomedical Sciences at Tufts.
Not exact matches
Previous studies have revealed that exercise
induces the production of
irisin and its precursor molecule, FNDC5 (fibronectin - type III domain - containing 5) protein, which convert white fat tissue into beneficial, calorie - burning brown fat.
Two weeks of voluntary wheel running
induces higher expression of
irisin — a fat - burning hormone that is released during exercise — in bone tissue in mice.
«Exercise -
induced hormone
irisin is not a «myth».»
This possibility is not exclusive to myostatin, because the cytokine interleukin - 6 (IL - 6) also plays a critical role in exercise -
induced muscle hypertrophy, and the secreted hormone
irisin is released in response to exercise and promotes energy expenditure (57).
Potentially, if turned into a viable drug,
irisin could
induce the benefits of a workout without the workout (Photo: iStock)
Spiegelman and his colleagues suspected that FNDC5 (and the
irisin created from it) was responsible for exercise -
induced benefits to the brain — in particular, increased levels of a crucial protein called brain - derived neurotrophic factor (BDNF), which is essential for maintaining healthy neurons and creating new ones.
This possibility is not exclusive to myostatin, because the cytokine interleukin - 6 (IL - 6) also plays a critical role in exercise -
induced muscle hypertrophy, and the secreted hormone
irisin is released in response to exercise and promotes energy expenditure (57).