Muscle - type phosphofructokinase (PFK) deficiency causes alkaline -
induced hemolytic crises and exertional
myopathy in English Springer Spaniel (ESSP) dogs and is inherited as an autosomal - recessive trait.
Affected littermates exhibited signs clinically distinct from neuromuscular disorders previously characterized in the breed: exercise -
induced collapse (EIC)[14], centronuclear
myopathy (CNM)[15], and myotubular
myopathy [16].