Sentences with phrase «induced obesity»

In many mammal models of diet - induced obesity, leptin resistance is seen initially at and within the signaling though the vagal afferents into the area postrema.

Klaus S, Pultz S, Thone - Reineke C, Wolfram S. Epigallocatechin gallate attenuates diet - induced obesity in mice by decreasing energy absorption and increasing fat oxidation.

Also, combination therapy using the two agents may be more effective in preventing diet induced obesity than either agent alone.»

Typical western diets consist of poor food choices over a lifetime that can contribute to diet - induced obesity, systemic inflammation and a variety of other pathological conditions.

Typical western diets consist of poor food choices over a lifetime that can contribute to diet - induced obesity, systemic inflammation and

Modulation of central leptin sensitivity and energy balance in a rat model of diet - induced obesity

However in the article to which you refer, the phrase «The researchers measured insulin sensitivity in eight male dogs before and after diet - induced obesity.»

The increase in intracellular NAD elicited by CD38 deletion significantly activated SIRT1 and prompted clinical phenotypes similar to those expected for SIRT1 activation, including protection against diet - induced obesity and a robust deacetylation of SIRT1 targets.

Similarly, NR supplementation attenuated HFD - induced obesity in mice, improved insulin sensitivity and glucose tolerance, and ameliorated the adverse lipid profile [54, 162].

The MSG - induced obesity in rats was on diets of 2 - 4g / kg per day (or two) of weight.

Walewski, J. L., et al. «Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet ‐ induced obesity.»

In this case, you may start to see the ravages of stress and high cortisol: sugar cravings, increased fat storage, and ultimately, stress - induced obesity.

Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet - induced obesity via Nrf2 mediated pathway.

The endocannabinoid system regulates energy homeostasis through G protein — coupled cannabinoid - 1 receptors5, 6 located in the central nervous system and in various peripheral tissues, including adipose tissue, muscle, the gastrointestinal tract, and the liver.7 While peripheral cannabinoid - 1 receptor activation decreases adiponectin production in adipocytes, 8 central cannabinoid - 1 receptor activation in preclinical studies stimulates eating, decreases muscle, and stimulates hepatic and adipose tissue lipogenic pathways in animal models of obesity.9 In genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorders.

May contribute to the development of diet - induced obesity and several obesity - associated features, such as dyslipidemia and liver steatosis, regulating peripheral lipogenesis, energy expenditure and feeding behavior.

To explore if Hedgehog signaling also has an effect on diet - induced obesity after birth, Long and his team genetically engineered mice so that the Hedgehog pathway in fat cells would activate when they ate a high - fat diet.

In high carbohydrate diet - induced obesity, may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase / DLD in striated muscles, as well as that of selected glucose / pyruvate metabolic enzymes, hence affecting energy expenditure through mitochondrial metabolism (PubMed: 26671069).

Complete loss of mitochondrial CLPP protease protects mice from diet ‐ induced obesity and insulin ‐ resistance but impairs cold ‐ induced thermogenesis due to a decline in brown adipocyte function.

Resistance to diet - induced obesity in mice with a single substituted chromosome.

Adaptive changes in adipocyte gene expression differ in AKR / J and SWR / J mice during diet - induced obesity.

When planning a diet - induced obesity study, the composition of the high - fat diet deserves attention.

Variation in type 2 diabetes - related traits in mouse strains susceptible to diet - induced obesity.

Sex differences during the course of diet - induced obesity in mice: adipose tissue expandability and glycemic control

Differential Mechanisms and development of leptin resistance in A / J versus C57BL / 6J mice during diet - induced obesity.

Metlakunta AS, Sahu M, Sahu A. Hypothalamic phosphatidylinositol 3 - kinase pathway of leptin signaling is impaired during the development of diet - induced obesity in FVB / N mice.

Paradoxical resistance to diet - induced obesity in UCP1 - deficient mice.

Diet - induced obesity and cardiovascular regulation in C57BL / 6J mice.

Adaptive changes in adipocyte gene expression differ in AKR / J and SWR / J mice during diet induced obesity.

Variation in type 2 diabetes — related traits in mouse strains susceptible to diet - induced obesity.

Meal pattern analysis of diet - induced obesity in susceptible and resistant rats.

Effect of salt on hypertension and oxidative stress in a rat model of diet - induced obesity.

Enhanced vascular contractility and diminished coronary artery flow in rats made hypertensive from diet - induced obesity.

The triple uptake inhibitor (1R, 5 S)- (+)-1 -(3,4 - dichlorophenyl)-3-azabicyclo [3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet - induced obesity.

Glucagon receptor knockout mice are resistant to diet - induced obesity and streptozotocin - mediated beta cell loss and hyperglycaemia.

Pioglitazone prevents hypertension and reduces oxidative stress in diet - induced obesity.

«This means that if the mothers consume adequate vitamin A, in a safe dose, during their pregnancy, their offspring are less susceptible to diet - induced obesity and related diseases,» said Wang.

Perilipin -2-null mice are protected against diet - induced obesity, adipose inflammation, and fatty liver disease.

During his postdoctoral training, he studied the development of diet - induced obesity in selectively - bred strains of Sprague - Dawley rats that either become obese or remain lean when exposed to a high - fat diet.

Specific synbiotics in early life protect against diet - induced obesity in adult mice Mona Mischke — Diabetes, Obesity, and Metabolism

In the first part, they established the mouse model that mimics multiparity - induced obesity in humans.

In the current study, we found that while a high fat diet containing Plenish also induced obesity, glucose intolerance and fatty liver, it did not induce insulin resistance as did the conventional soybean oil.

The upregulation of Il15 mRNA in skeletal muscles from IL - 15Rα — KO mice reported in the current study could potentially contribute to the altered body composition observed in these mice (14), as HSA - IL - 15TG mice had lower adiposity and were resistant to high - fat diet — induced obesity (34).

To make their discovery, Jin and colleagues used both genetically obese mice and mice with diet - induced obesity as models.

Osteocalcin - deficient mice exhibit insulin resistance and hyperglycemia (27), and administration of undercarboxylated osteocalcin protects against the metabolic consequences of diet - induced obesity in WT mice (30, 60).

We examined six experimental groups of 20 - week - old C57BL / 6J mice: (a) lean C57BL / 6J female mice, (b) lean C57BL / 6J male mice, (c) moderately obese C57BL / 6J male mice with diet - induced obesity, (d) moderately obese female B6.Cg Ay / + mice, (e) severely obese female B6.V Lepob / ob mice, and (f) severely obese male B6.V Lepob / ob mice.

These results contribute to the understanding of the mechanisms that underlie diet - induced obesity and offer insight into how fermentable fibers might promote better health.»

Dr. Eibl and colleagues set out to develop diet - induced obesity and development of pancreas cancer in a set of mice and then compare them to another set of mice that are genetically identical but not given a high - fat, high - calorie diet.

In male mice, however, diet - induced obesity made more active inflammatory white blood cells and enhanced their progenitors.

«We provide the first evidence that the PPARα - dependent gene Fgf21 demethylation occurs in the postnatal mouse liver, and once established it persists into adulthood and exerts long - term effects on the magnitude of gene expression response to environmental cues, which may account in part for the attenuation of diet - induced obesity (Figure).»

«Our research shows that targeting cannabinoid receptors in the periphery with pharmacological inhibitors that do not reach the brain holds promise as a safe therapeutic approach for the treatment of overeating and diet - induced obesity,» said Nicholas V. DiPatrizio, an assistant professor of biomedical sciences in the School of Medicine, who led the research project.