Sentences with phrase «induced osteoclast»
To directly examine whether ABL kinases regulate tumor - induced osteoclast activation, we used an in vitro osteoclastogenesis assay (Fig. 5A).
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Depletion of ABL kinases impairs tumor - induced osteoclast activation in part by decreasing IL - 6 secretion.
These findings suggest that ABL kinases promote tumor - induced osteoclast activation in part by increasing OPG abundance in osteoblasts.
In the present study, the researchers focused on the role of MCP - 1 in PTH - induced osteoclast formation.
These products, including the major malarial by - product hemozoin, malarial proteins and as yet undefined virulence factors, induce MyD88 - dependent inflammatory responses in osteoclast and osteoblast precursors, leading to increased RANKL expression (a key molecule inducing osteoclast differentiation), and over-stimulation of osteoclastogenesis favoring bone resorption.»
IL - 6 can induce osteoclast activation indirectly by altering the expression of RANKL and OPG in osteoblasts (51).
IL - 6 is a multifunctional cytokine with pleiotropic functions that include inducing osteoclast activation, enhancing bone resorption, and increasing metastasis (33 — 35).
Not exact matches
Denosumab, a fully human monoclonal antibody drug, binds specifically to RANK - ligand (RANKL) and inhibits osteoclast - induced bone resorption by preventing the binding of RANKL to RANK.
«MCP - 1 is a chemokine, which induces cells to move along a gradient recruiting white cells and osteoclasts in tissues,» says Dr. Partridge.
4 - 1BBL was largely thought to be on APC that have been activated for several days, such as dendritic cells, B cells, and macrophages although again it is clear that 4 - 1BBL is now more ubiquitous as it has been visualized to be induced on diverse cell types such as mast cells, osteoclasts, smooth muscle, and stem cells.