Sentences with phrase «induced tumors in mice»

The incidence of herpes virus type 2 - transformed cell - induced tumors in mice was also reduced in animals fed a fish protein diet.

Not exact matches

While study results indicated that combining capsaicin with the chemicals «might promote cancer cell survival,» the report clearly stated that the control group of mice treated only with capsaicin ``... did not induce any skin tumors...» In addition, the study repeatedly cited other research studies in which the anti-cancer properties of capsaicin were solidly demonstrateIn addition, the study repeatedly cited other research studies in which the anti-cancer properties of capsaicin were solidly demonstratein which the anti-cancer properties of capsaicin were solidly demonstrated.

In contrast, treatment with only capsaicin or vehicle did not induce any skin tumors in either TRPV1 / WT or KO mice (Table 1; Fig. 1C), indicating that capsaicin alone does not act as a carcinogeIn contrast, treatment with only capsaicin or vehicle did not induce any skin tumors in either TRPV1 / WT or KO mice (Table 1; Fig. 1C), indicating that capsaicin alone does not act as a carcinogein either TRPV1 / WT or KO mice (Table 1; Fig. 1C), indicating that capsaicin alone does not act as a carcinogen.

Topical application of capsaicin on the dorsal skin of 7,12 - dimetylbenz (a) anthracene — initiated and TPA - promoted TRPV1 wild - type (WT) and TRPV1 knockout (KO) mice induced more and larger skin tumors in TRPV1 / KO mice, suggesting a TRPV1 - independent mechanism.

In this new study published in Nature, Alexandra Van Keymeulen and colleagues used state of the art genetic mouse models to identify the cellular origin of PIK3CA and p53 induced breast tumorIn this new study published in Nature, Alexandra Van Keymeulen and colleagues used state of the art genetic mouse models to identify the cellular origin of PIK3CA and p53 induced breast tumorin Nature, Alexandra Van Keymeulen and colleagues used state of the art genetic mouse models to identify the cellular origin of PIK3CA and p53 induced breast tumors.

Several studies have supported a role for cancer stem cells in the aggressive brain tumors called glioblastoma, but those studies involved inducing human tumors to grow in mice, and as such their relevance to cancer in humans has been questioned.

Loss of either GSTO1 or RYR1, the researchers report, decreased the number of cancer stem cells in the primary tumor, blocked metastasis of cancer cells from the primary tumor to the lungs, decreased the duration of chemotherapy required to induce remission and increased the duration of time after chemotherapy was stopped that the mice remained tumor - free.

Terbinafine, a U.S. Food and Drug Administration — approved antifungal drug targeting SQLE, markedly inhibited SQLE - induced NAFLD - HCC cell growth in NAFLD - HCC and HCC cells and attenuated tumor development in xenograft models and in Sqle transgenic mice.

They detected the presence of an enzyme that can induce tumor metastasis, MMP - 2 (matrix metalloproteinase - 2) in mice with cancer.

These compounds have been shown to inhibit cancer cell growth, induce cancer cell apoptosis, and reduce tumor volume in mice (14, 15, 16, 17).

In mouse models, carcinogen - induced tumors that arise in immunodeficient mice, when transplanted to wild - type mice, are usually eliminated by the intact immune system of the new hosIn mouse models, carcinogen - induced tumors that arise in immunodeficient mice, when transplanted to wild - type mice, are usually eliminated by the intact immune system of the new hosin immunodeficient mice, when transplanted to wild - type mice, are usually eliminated by the intact immune system of the new host.

In contrast, tumors induced in wild - type mice often grow when transplanted to other wild - type micIn contrast, tumors induced in wild - type mice often grow when transplanted to other wild - type micin wild - type mice often grow when transplanted to other wild - type mice.

However, tumors induced in wild - type mice have arisen despite an intact immune system.

Drew Pardoll, Glenn Dranoff, Elizabeth Jaffee, Hyam Levitsky, and colleagues conduct preclinical studies showing that a vaccine composed of tumor cells irradiated and genetically modified to produce immune system growth factor GM - CSF (granulocyte - macrophage colony - stimulating factor)-- which would become known as the therapeutic cancer vaccine GVAX — could induce potent, specific, and long - lasting anti-tumor immunity in multiple mouse tumor models.

In this study, we have addressed the role of p21 in tumor suppression by directly assessing the susceptibility of p21 - null mice to spontaneous tumors and also to radiation - induced tumorIn this study, we have addressed the role of p21 in tumor suppression by directly assessing the susceptibility of p21 - null mice to spontaneous tumors and also to radiation - induced tumorin tumor suppression by directly assessing the susceptibility of p21 - null mice to spontaneous tumors and also to radiation - induced tumors.

As it was the case among irradiated wild - type mice, the predominant tumors induced by radiation in p21 - null mice were T - cell lymphomas (Table 3) ⇓.

Intermittent Hypoxia - induced Changes in Tumor - associated Macrophages and Tumor Malignancy in a Mouse Model of Sleep Apnea.

An account of the discovery that tumors in mice metabolize glucose and glutamine differently depending on whether they are induced by the Myc or Met oncogene and on which tissue the tumors arise in.

Furthermore, although mutation of p21waf1 / cip1 is uncommon in cancers (12), p21waf1 / cip1 - deficient mice show susceptibility to spontaneously or chemically induced tumor formation (13 — 15).

We found that allosteric inhibition of the ABL kinases effectively impaired breast cancer bone metastasis and blocked tumor - induced osteolysis in mouse models.

Although vaccination induces an inflammatory response during pregnancy, the magnitude and the duration of response is much lower and shorter, respectively, for influenza vaccination than viral infection.27 Like infection, influenza vaccination during pregnancy has been reported to induce a transient increase in the levels of a number of proinflammatory cytokines, including interleukin 6, tumor necrosis factor α, and C - reactive protein.27 - 30 Studies on mice found an association between high interleukin - 6 levels during pregnancy and abnormal behavior and brain structure.19 However, in epidemiological studies, associations between maternal cytokine levels and ASD have been mixed.

First, they induced lung tumors in the mice by giving the mice chemicals.