Sentences with phrase «induces cell cycle»

Sulforaphane induces cell cycle arrest by protecting RB - E2F - 1 complex in epithelial ovarian cancer cells.

Shapiro GI, Koestner DA, Matranga CB, et al: Flavopiridol induces cell cycle arrest and p53 - independent apoptosis in non-small cell lung cancer cell lines.

We also show that rapamycin and total mTOR silencing induces cell cycle arrest and apoptosis interfering with proliferation and survival pathways in ALK + ALCL.

Inhibition of mTOR induces cell cycle arrest in ALCL cells.

It induces cell cycle arrest and senescence, an irreversible resting state marking these «out - of - order» cells to be cleared by the immune system.

Increasing β - catenin / Wnt3A activity levels drive mechanical strain - induced cell cycle progression through mitosis.

Cell cycle studies also showed that inhibition of mTOR function by using rapamycin or inhibition of mTOR expression by using mTOR - specific siRNA induced cell cycle arrest as shown by a dose - dependent decrease of cell cycle S phase (data not shown).

These results suggest that inhibition of mTOR - raptor complex or silencing mTOR gene expression induced cell cycle arrest at G1 phase in ALK + ALCL cells.

We also show that inhibition of mTOR with rapamycin, as well as silencing mTOR gene product expression using mTOR - specific small interfering RNA, decreased phosphorylation of mTOR signaling proteins and induced cell cycle arrest and apoptosis in ALK + ALCL cells.

TGFβ inhibits tumor initiation and progression by inducing cell cycle arrest and apoptosis; however epithelial tumorigenesis may escape this common antitumor mechanism by inducing aberrations in TGFβ signaling resulting in enhanced development and progression of human carcinomas.

Currently we are using new transgenic approaches to mark and isolate the proliferating cardiomyocytes and we generate single - cell transcriptomics and regulomics data to identify the mechanisms inducing cell cycle re-entry.

Not exact matches

It is well known that ribosome biogenesis is a key component of the cell cycle as it regulates cell size and growth and the IBS team has uncovered that SSUPs play a critical role in maintaining induced pluripotent stem cell integrity.

In normal cells, this is a part of the wound repair process when PGE2 induces tissues stem cells to regrow; in cancer PGE2 ironically induces regrowth of more cancer stem cells in between chemotherapy cycles, Kurtova and Xiao said.

Other studies have shown that the virus is capable of moving into brain cells, modifying the regulation of the cell cycle, and inducing their death.

«The cancer stem cells actively regrow and respond to the induced damage or apoptosis (cell death) caused by chemotherapy in between the different cycles, similar to how normal tissue stem cells respond to wound - induced damages.»

When instead the scientists suppressed activity in the same nerve - cell population during the typically active period of the mice's 24 - hour cycle, the mice conked out, snoozing through the presence of surefire arousal triggers: delicious high - fat chow, a female or fear - inducing fox urine.

When the researchers induced the clock cycles to shift with chemicals or slight changes in temperature, they found that the cells also varied in their adaptability to change, in keeping with the volunteers» reports of varying responses to jet lag and other disruptions.

While looking carefully at the areas of cell destruction induced by the viruses — called plaques — he and colleagues noticed that vaccinia spread four times faster than its replication cycle would allow.

In addition, the parasexual cycle is induced between two a / a mating partners when mixed in ménage a trois matings with a limited number of α / α cells that serve as pheromone donors to trigger unisexual a-a reproduction [43].

«While it was known that palbociclib stalls proliferation by inhibiting CDK4 / 6, inducing proteasomal activity may be an additional mechanism that ensures the completeness of the cell cycle arrest,» says Dr. Mikael Björklund, one of the lead authors of the study.

The authors discovered that FGF2 treatment forced a high percentage of astrocytic cell - cycle re-entry via FGF receptor - induced phosphorylation of ERK and mediated the generation of self - renewing Nestin - expressing NSCs.

Furthermore; p16INK4a inhibits CDK4 and CDK6, and induces phosphorylation of the protein retinoblastoma (Rb) and liberating the transcription factor E2F which consequently result in cell cycle progression [29].

Static mechanical strain induces capillary endothelial cell cycle re-entry and sprouting.

Thus, MyoD may induce terminal cell cycle arrest during skeletal muscle differentiation by increasing the expression of p21.

«This idea fits nicely with the findings from a number of groups — that forced expression of cell cycle regulators can induce cardiomyocyte proliferation in mammals,» says Jopling.

In our study, we found that exposing metastatic breast cancer cell lines to hypoxia and reoxygenation cycles induces a unique subpopulation that is highly metastatic and exhibits stem - like and EMT phenotypes.

Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation.

Its major target genes include proapoptotic genes Bax, Puma and Noxa, cell cycle regulator p21, and the senescence - inducing gene Plasminogen activator inhibitor 1 [5].

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

Gadd45b plays a role in cell cycle arrest, and it is a positive mediator in Fas - induced apoptosis when a DNA injury appeared in nonneoplasic cells [28].

Our «biased» profiling is based on an in vitro model of mouse terminally differentiated myotubes, induced to re-enter the cell cycle by the E1A oncogene (23).

In this case, the viral protein managed to deregulate the cell cycle and induce oncogenesis.

In cells from certain brain tumors, in stomach cancer, and in colorectal cancer lines, vitamin K halts the reproductive cell cycle and induces apoptosis.

This may be why a UK study found that athletes who consumed dark chocolate prior to exhaustive cycling experienced less exercise - induced cell stress.

Saturated fat causes more of those toxic breakdown products and mitochondrial dysfunction, and increases oxidative stress, free radicals, and inflammation, establishing a vicious cycle of events in which saturated fat - induced free radicals cause dysfunction in the little power plants within our muscle cells, which causes an increase in free radical production and the impairment of insulin signaling.

For example, Dr. Greger discusses a» vicious cycle of events in which saturated fat induced free radicals causes dysfunction in the little powerplants within our muscle cells, which causes an increase in free production and impairment of insulin signaling.»

In an in vitro study, vanillin induced apoptosis and arrested the cell cycle of human colorectal cancer cells, and some researchers think vanillin could reduce the metastatic potential (ability to spread to other parts of the body) of human cancer cells in vivo, too.

González - Sarrías, A.; Ma, H.; Edmonds, M.E.; Seeram, N.P. Maple polyphenols, ginnalins A-C, induce S - and G2 / M - cell cycle arrest in colon and breast cancer cells mediated by decreasing cyclins A and D1 levels.

✓ Cytotoxicity — WGA has been demonstrated to be cytotoxic to both normal and cancerous cell lines, capable of inducing either cell cycle arrest or programmed cell death (apoptosis).