Sentences with phrase «induces hematopoietic»

Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice.

This process (see figure) started with spin - embryoid body (spin - EB) formation from cultures of single - cell hiPSC suspensions in 96 well plates, and the subsequent addition of BMP4 and FGF - 2 to induce mesoderm differentiation, and then VEGF and SCF to induce hematopoietic differentiation.

C / EBPdelta deficiency sensitizes mice to ionizing radiation - induced hematopoietic and intestinal injury.

Not exact matches

In contrast, the safety record of hematopoietic stem cell gene therapy is less clear, with a significant frequency of gene - therapy induced oncogenesis or clonal outgrowth reported in several hematopoietic stem cell trials [56], [57].

The chemokine receptor CXCR - 4 is expressed on CD34 + hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell - derived factor - 1.

Chemotherapy - induced bone marrow nerve injury impairs hematopoietic regeneration.

Professor Kyurkchiev's group is currently developing a project on the controlled differentiation of human induced pluripotent stem cells into hematopoietic stem cells and lymphoid cells.

It is well known that HDAC inhibitors are potent anticancer drugs in hematopoietic malignancies, including lymphoma.19 — 21 The aim of using HDAC inhibitors is to restore normal histone modification patterns through inhibition of various components of the epigenetic machinery.22, 23 In B - cell lymphoma, HDAC inhibitors can rescue deficits in histone acetylation induced by EP300 / CREBBP mutations, 24 rendering tumor cells more sensitive to suberoylanilide hydroxamic acid.25 This can explain why chidamide also has favorable efficacy on PTCL - NOS patients bearing EP300 / CREBBP mutations.

RIG - G gene expression can be induced not only by ATRA along with the differentiation of NB4 cells but also by IFNα in a series of hematopoietic cell lines as well as various types of solid carcinoma cells (1, 3), which pointed to a possible role of RIG - G in signal cross-talk between ATRA and IFNα.

Retinoic acid — induced gene G (RIG - G), a gene originally identified in all - trans retinoic acid — treated NB4 acute promyelocytic leukemia cells, is also induced by IFNα in various hematopoietic and solid tumor cells.

More recently, recombinant TAT - HOXB4 was used to expand hematopoietic stem cells up to 20-fold without the need for viral gene transfection, avoiding the potential hazards of inducing lymphoproliferative disease [15].

Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment.

Telomere dysfunction induces environmental defects limiting hematopoietic stem cell function and engraftment.

Thus, one can transplant fully allogeneic hematopoietic stem cells and co-transplant, for example, hearts from the hematopoietic stem cell donor to induce lifelong donor - specific acceptance of the transplant, without deleterious immunosuppression [4].