In a continuation of this work, Goldman is also using mathematical modeling to pursue the most effective dose of chemotherapy to
induce the
vulnerable transition state of the cancer
cell demonstrated in this research.
Human pluripotent stem
cells (hPSCs), including human embryonic stem
cells (hESCs) and human
induced pluripotent stem
cells (hiPSCs), are known to be
vulnerable to apoptosis upon various technical manipulation, such as single
cell dissociation, freezing and thawing, etc., which hinder their use for clonal isolation in gene transfer, differentiation and FACS
cell sorting.