Sentences with word «inducible»

Another important molecule, the transcription factor hypoxia inducible factor - 1 (HIF - 1), is well established as a key molecular signal linking oxygen level to gene expression in many tissues.

Zuzana Kirsnerova (Baretton, TUD)-- «The role of Hypoxia Inducible Factors in physiological and pathological angiogenesis» (2006)

In animal studies, activation of nuclear factor - kappa B (NF - kB); activation of inducible nitric oxide synthase (iNOS), and cyclooxygenase - 2 (COX - 2); and formation of malondialdehyde (MDA) have all be shown to get reduced following consumption of either sweet potato or its color - containing extracts.

«Together, our data strongly suggest that cutaneous gene therapy with inducible expression of GLP1 can be used for the treatment and prevention of diet - induced obesity and pathologies,» the authors wrote.

Gesicle loading utilizes the iDimerize system, which enables inducible protein - protein interactions: The membrane - bound CherryPicker red fluorescent protein on the surface of the gesicle is tagged with one dimerization domain, and the Cas9 endonuclease contains another dimerization domain.

Using inducible cell lineage tracing, we have found that early Pax7 - expressing somitic cells directly give rise to adult muscle stem cells, i.e. the satellite cells.

In wild - type mouse blood vessels, estrogen attenuates vasoconstriction by an ERβ - mediated increase in inducible nitric oxide synthase expression.

For further temporal control, Tamoxifen inducible Cre versions can be used in these experiments.

In addition to PBAD, several other inducible promoter systems were evaluated in R. eutropha.

«I saw this as the perfect inducible model system.

To determine inducible endothelial cell adhesion molecule expression (E-selectin, VCAM - 1, and ICAM - 1), some of the chambers were given medium containing 10 ng / ml TNF - α for 4 — 6 h (these time points were selected to correlate with the known kinetics of endothelial cell adhesion molecule expression; Refs.

In contrast for ranavirus, a highly virulent pathogen capable of decimating amphibian populations, populations living close to agriculture with high baseline tolerance had higher viral loads than populations far from agriculture with inducible tolerance.

For the trematode, wood frogs living closer to agriculture with high baseline tolerance had lower trematode loads than populations living far from agriculture with inducible pesticide tolerance.

Another research group had shown that an enzyme called salt - inducible kinase inhibits melanin production in mice and that animals lacking the gene for this enzyme developed darkened fur.

Established a Jurkat cell model of HIV latency (5A8 cells) that is inducible by T - cell receptor cross-linking and displays drug reactivation profiles resembling that from resting CD4 T cells from aviremic patients.

To impute aging phenotypes directly to p16Ink4a - expressing senescent cells, van Deursen and colleagues with expertise in the aging and senescence of the relevant tissues developed and tested the effects of a pharmacologically - inducible system for the ablation of p16Ink4a - expressing cells.

Specifically, the study published in the May issue of Nature Immunology and led by La Jolla Institute Professor Shane Crotty, Ph.D., and Instructor Kok - Fai Kong, Ph.D., reported that an enzyme called TANK - binding kinase 1 (TBK1) controls the maturation of antibodies by associating with a key signaling molecule known as Inducible T cell Co-Stimulator or ICOS.

His current research focuses on inducible negative feedback regulation of inflammation, which provides novel insights into the tight regulation of inflammation and may lead to the identification of novel therapeutic targets.

Human gingiva - derived MSCs can induce IL - 10, IDO, inducible NO synthase and cyclooxygenase 2 thereby serving as immunomodulatory components in the treatment of experimental inflammatory diseases 43.

[7] Loss of VHL leads to dyregulated hypoxia inducible pathways and highly vascular renal tumors.

Elledge, who collaborated with Abraham Brass of Massachusetts General Hospital in Boston, found an entire family of these, called interferon - inducible transmembrane proteins.

Many of the genes known to be directly transactivated by the overexpression of the transcription co-factor HIF - 1α were identified, and included inducible nitric oxide synthetase 2, insulin - like growth factor 1, insulin - like growth factor binding protein 2, and hexokinase 2.

Positive feedback regulation of type I IFN genes by the IFN - inducible transcription factor IRF - 7.

lab has developed a CRISPR / Cas - based system for tagging endogenous proteins with an auxin - inducible degron (AID) tag to generate proteins which can be

Knockdown of menin affects pre-mRNA processing and promoter fidelity at the interferon - gamma inducible IRF1 gene.

Some wondered if this would translate into meaningful gains, I believe it may help but it will be therapeutic in nature (it will reduce inducible senescence (pathological aging) because SASP is inflammation - excess state).

Lepper, C. & Fan, C.M. Inducible lineage tracing of Pax7 - descendant cells reveals embryonic origin of adult satellite cells.

I had also shown that when I fused it to the herpesvirus thymidine kinase (TK) gene, I could get heat - inducible TK transcripts in mammalian cells.

They found IL - 10 promotes intestinal epithelial wound repair through the activation of cAMP response element - binding protein (CREB) signaling at the sites of injury, followed by synthesis and secretion of the WNT1 - inducible signaling protein 1 (WISP - 1).

J. Moyron - Quiroz et al., Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity.

In the research, the authors describe for the first time the generation of steroid - producing cells (named human inducible steroidogenic cells, hiSCs) from skin, blood and urine of healthy donors and patients with congenital adrenal disorders.

Furthermore, gel shift analysis revealed that these GAF proteins, detected after either EGF or IFN - gamma administration, specifically bound to the sis - inducible element of the c - fos promoter.

This was achieved by placing a modified h beta - AR gene under control of the galactose - inducible GAL1 promoter.

By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light - inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.

This helped to confirm that in addition to relying on leaky blood vessels for nanoparticles to gain access to the tumor, a major inducible vascular transit pathway is available in the form of the vesicle transport system.

In animals harboring intraperitoneal hollow - fiber or subcutaneous implants containing light - inducible transgenic cells, the serum levels of the human glycoprotein secreted alkaline phosphatase could be remote - controlled with fiber optics or transdermally regulated through direct illumination.

Thomson and Yamanaka had published independent studies the previous fall saying they could turn normal skin cells into inducible pluripotent stem cells (ones that are most therapeutically useful because they can become any of the 200 different types of cells in the body); Bush was saying that this new type of stem cell would give us all the biological usefulness of the embryonic variety with none of the nasty ethical hang - ups.

Engineered bacterial cells that are designed to express therapeutic enzymes under the transcriptional control of remotely inducible promoters can mediate the de novo conversion of nontoxic prodrugs in their cytotoxic forms.

When a protein called stress - inducible phosphoprotein 1 (STI1) interacts with the prion protein preventing the interaction of amyloid - β peptides, it protects neurons.