Sentences with phrase «inducing mcd»

Importantly, when treated with steatosis - inducing MCD - media, enhanced hiPS - HEP cells show elevated expression of TNFα mRNA (Figure 6, Panel B).

Not exact matches

MCD diet - induced NASH is reversible in rats by switching to a diet with suffcient methionine and choline (15).

In a follow - up study, Pickens et al. showed that despite inducing the same overall level of hepatic fat accumulation, fructose was more effective than glucose at inducing hepatocellular injury in mice fed MCD diets for 21 days (16).

Importantly, unlike human or other diet - induced rodent models of NAFLD, rodents fed MCD diets lose weight (due to a vastly lower caloric intake) and do not become insulin resistant (9, 19).

Sucrose is an important component of the MCD diet, since replacing it with corn starch greatly reduces liver fat accumulation, inflammation and injury, likely through reductions in sucrose - induced de novo lipogenesis and triglyceride synthesis (17).

A combined methionine and choline deficiency (MCD) actually causes weight loss and reduces serum triglycerides and cholesterol, but induces more severe liver damage.