Sentences with phrase «inducing cell»

This type of training causes damage to the muscle fibers, instead of inducing cell fatigue.

Shiitakes, of course, contain many of the superpower health benefits of mushrooms, including reducing cholesterol levels, helping maintain healthy weight levels, boosting immunity, and even helping to fight cancer by inducing a cell cleansing process called apoptosis.

Currently we are using new transgenic approaches to mark and isolate the proliferating cardiomyocytes and we generate single - cell transcriptomics and regulomics data to identify the mechanisms inducing cell cycle re-entry.

TGFβ inhibits tumor initiation and progression by inducing cell cycle arrest and apoptosis; however epithelial tumorigenesis may escape this common antitumor mechanism by inducing aberrations in TGFβ signaling resulting in enhanced development and progression of human carcinomas.

Kyoto University cell biologists wanted to find out if «flipping» enzymes belonging to the P4 - ATPase family were involved in inducing cell membranes to change shape.

It was originally thought that ATRA was successfully treating APL by inducing cell differentiation, causing cancer cells to change into normal cells by activating the cellular retinoic acid receptors.

The study nicely demonstrates how leukemia cells create space for themselves in the bone marrow by inducing cell death, says Michael Kharas, a molecular biology graduate student at the University of California, Irvine.

Four clinical studies have revealed that histone deacetylase (HDAC) inhibitors are the most effective LRA for inducing cell - associated HIV - 1 RNA.

Research has shown that artichoke leaf extract has key antioxidants for inducing cell death (apoptosis) and slowing cancer cell growth.

Cannabis prevents cancer; the cannabinoids induce cell death of damaged cells & promote blood flow positively.

For example, beyond the cell fusion effects of myomaker and myomerger, it isn't known how myomaker or myomerger induce cell membrane fusion.

The researchers also affected mouse models with Mantle Cell Lymphoma, using the new platform to target cancer cells, induce cell death and dramatically improve overall survival.

«Damaging consequences of Zika virus infection in human minibrains: Zika virus reduces growth, induces cell death, malformations in human neurospheres, brain organoids.»

Instead, Sen found that actin was trafficked into the nuclei of the stem cells, where it had the surprising effect of inducing the cells to become osteoblasts.

Like mRNA, gene therapy can induce cells to make therapeutic proteins, but it typically introduces DNA that can integrate unpredictably into the genome.

«We also know that this RhoB pathway, once turned on, can stimulate the expression of two proteins: p21, which prevents cells from replicating, and BIM, which induces cell death — both of which can help stop cancer growth.»

Once the inflammatory process has been initiated, neutrophils within the joint space release interleukin - 1, which induces cells lining the joint space to produce chemoattractants called chemokines that further facilitate the movement of neutrophils into the joint space.

«In time, knowledge of the mechanism by which KIF1B - β induce cell death might prove important in attempts to develop new neuroblastoma therapies.»

We were able to use pharmaceuticals to induce cell self - eating effects and stimulate dedifferentiation though not as effectively as 3D culture, so we need to do more work on this.

In 2013, the team found that nitric oxide is involved in cocaine - induced cell death through its interactions with GAPDH, an enzyme, but didn't learn how precisely the cells were dying.

or to induce cell death.

«Their properties and the ability to induce these cells by vaccination provide a tremendous opportunity to target and reduce the viral reservoir in lymphoid tissues.»

A new study led by University of Kentucky researchers suggests that activating the tumor suppressor p53 in normal cells causes them to secrete Par - 4, another potent tumor suppressor protein that induces cell death in cancer cells.

The hormone estrogen represses genes, such as HOXC10, that induce cell death and inhibit growth.

It is not known whether tryptophan byproducts from L. reuteri induce the cells to develop in people as they do in mice, but defects in genes related to tryptophan have been found in people with inflammatory bowel disease.

Receptors are protein structures that molecules bind with to induce cells to respond.

«The research showed that the aggressive form of basal breast cancer cells may be dependent on PLK4 for survival and that depleting it induced cell death,» says Dr. Mak.

In the studies led by Kanneganti, Kuriakose and colleagues first sought to identify the specific machinery that the innate immune system uses to induce cell suicide.

So they turned to a second DNA - targeting technique, known as TALENs, that entails inducing cells to produce enzymes that work together like a pair of scissors to cut DNA.

The analysis indicated that 48 hours of chokeberry extract treatment of pancreatic cancer cells induced cell death at 1 ug / ml.

«Never before has PTK6 inhibition been shown to inhibit growth and induce cell death of ER + breast cancer cells, including those resistant to standard treatments for this subtype such as tamoxifen,» said Hanna Irie, MD, PhD, Assistant Professor of Medicine (Hematology and Medical Oncology) and Oncological Sciences at The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, and senior author of the study.

By inducing cells that line the capillaries to keep a tight seal, astrocytes maintain the blood - brain barrier, which protects the brain from many circulating molecules.

The cell nuclei become fragmented, and some cells will even undergo apoptosis — auto - induced cell suicide.

Thus, by restraining metabolism in specific ways, GSK3 prevents ROS - induced cell death.

Plant defenses — which can include induced cell fortification, cell suicide, toxic chemicals, and defensive enzymes and proteins — typically were sufficient to keep the infection in check, but not strong enough to eliminate it.

The robotic system, described today in Science Robotics, induced cell proliferation and lengthened part of the esophagus in a large animal by about 75 percent, while the animal remained awake and mobile.

In this case, the researchers used samples from juveniles and adults with Fragile X syndrome and induced the cells to become neurons in a lab dish.

Kummer's group is working in an area that has intrigued biochemists for decades — the role of calcium in hormone - induced cell signalling.

«MCP - 1 is a chemokine, which induces cells to move along a gradient recruiting white cells and osteoclasts in tissues,» says Dr. Partridge.

«Probably, any molecule related to the nervous systems induce cell proliferation or differentiation during regeneration,» remarks Francesc Cebrià.

They bred mice that each had an extra X or Y chromosome, and then induced cells from their skin cells to become stem cells.

The scientists also found that exposing the uterine tract to seminal fluid decreased Trail, a cytokine that usually induces cell death.

McDonnell said is lab is continuing the research, including finding ways to induce cells to eject cholesterol, reverse the inhibition of CYP27A1 activity, or introduce compounds that interfere with cholesterol - production in the tumor.

The study found that the longer duration of exposure to high concentrations of local anaesthetic was most harmful because it interferes with the function of mitochondria, the «batteries» of the cell, and induce a cell death mechanism named «autophagy.»

Firstly, MSI1 binds to the Zika virus genome allowing it to replicate and making the cells more vulnerable to virus - induced cell death.

He adds that the stem cells used in the study have advantages over reprogrammed skin cells, including eliminating the tricky business of inducing the cells to become muscle cells, but he notes that both types of cells could pose risks because the virus used to modify them could cause cancer.

Activation of a gene induces a cell to make an RNA copy of its code, edit unneeded segments out of that message, and splice together a final version of the message that provides cellular factories (ribosomes) with a template to make one specific protein.

The drugs work by jamming some of cancer cells» machinery to induce cell death.

The activation of the oncogenes Cyclin E or Myc, on the other hand, induces the cells to begin replication of their DNA prematurely, without having had time to eliminate all the replication origins present in the genes.

The team led by Rory Fisher, Ph.D., professor of pharmacology in the UI Carver College of Medicine, has identified a protein called RGS6 (regulator of G protein signaling 6) that acts through two separate mechanisms to control alcohol - seeking behavior and alcohol - induced cell death in heart, liver, and other organs.