Among berries, I mostly consume strawberries (daily morning smoothie with a cup of frozen strawberries, half banana, cup water, 3 tbsp flax seed, 2 tbsp wheat germ), as their flavonoid, fisetin, appears particularly potent in
inducing cellular stress responses and crossing the blood brain barrier.
Not exact matches
They showed that ZIKV infection of cortical progenitors (stem cells for cortical neurons) controlling neurogenesis triggers a
stress in the endoplasmic reticulum (where some of the
cellular proteins and lipids are synthetized) in the embryonic brain,
inducing signals in response to incorrect protein con - formation (referred to as «unfolded protein response»).
Th ey found that host RNAs generated during
cellular stress could
induce an RLR - dependent inflammatory response.
Based on the previous evidences, it rusults important to maintain
cellular NAD + availability especially in mitochondria when
stresses induce a major consumption of NAD + and ATP and prone the organism more susceptible to ROS damages.
Using these orthogonal measures of
cellular pathway analysis, we confirmed that HPP - 4382, in contrast to bardoxolone, did not
induce significant
cellular stress at high doses as measured by HSPA6 expression and that the mechanism of HPP - 4382 activity does not appear dependent on NF - B as ICAM1 expression is not
induced by HPP - 4382 (data not shown).
In response to
cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to
induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].
Stress resistance has not been assessed however and so the biological relevance of this finding is currently unknown.32 Several IER trials (75 - 85 % ER on restricted days) in overweight / obese populations have reported reductions in various markers of oxidative stress 37, 41, which in one study was accompanied by a complementary increase in the anti-oxidant uric acid.37 In a direct comparison of IER (75 % ER for two days / week) and CER, both ER strategies displayed equal efficacy in reducing levels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Dire
Stress resistance has not been assessed however and so the biological relevance of this finding is currently unknown.32 Several IER trials (75 - 85 % ER on restricted days) in overweight / obese populations have reported reductions in various markers of oxidative
stress 37, 41, which in one study was accompanied by a complementary increase in the anti-oxidant uric acid.37 In a direct comparison of IER (75 % ER for two days / week) and CER, both ER strategies displayed equal efficacy in reducing levels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Dire
stress 37, 41, which in one study was accompanied by a complementary increase in the anti-oxidant uric acid.37 In a direct comparison of IER (75 % ER for two days / week) and CER, both ER strategies displayed equal efficacy in reducing levels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER -
induced activation of autophagy, a key homeostatic
cellular process in which dysfunctional or unnecessary
cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Directions
One reason might be the role of fat in
inducing oxidative
stress and creating free radicals, which are highly reactive atoms and molecules that damage DNA and
cellular walls, ultimately killing heart muscle cells.
Also noted by IER studies are an increase in the expression levels of silent mating type information regulation 2 homolog 1 (SIRT1), an NAD + - dependent deacetylase.20 The expression of SIRT1, also increased by prolonged ER in rodents, is linked to the up - regulation of
cellular stress resistance and improved outcomes in animal models of metabolic, neurodegenerative and inflammatory diseases.106, 107These findings have been suggestively accompanied by improvements in resilience to disease progression in rodent models of Type 1 diabetic nephropathy 20, survival following
induced ischaemic injury 21 and a reduction in oxidative
stress.105
''... we hypothesize that repeated
stress - related allostatic overload may affect brain function at three basic levels: (a) at the
cellular level, it may compromise proteostasis (e.g. tau protein), organelles homeostasis, and
induce epigenetic changes in neuronal DNA; (b) at the tissue level it may affect intracellular communication (synaptic contacts), number of cells (reduction of neuronal density), composition of the extracellular matrix (accumulation of amyloid plaques), and neuroinflammation; (c) at the systemic levels it may alter the brain's regulation of behavior (cognitive decline).
A multitude of plant hormetic compunds such as polyphenols, flavanols, luteolin, apigenin, anthocyanins, and pterostilbene — these compounds actually
induce a small
stress response in our cells which build
cellular resilience and health