Sentences with phrase «inducing dedifferentiation»
Hypoxia - induced dedifferentiation of tumor cells — a mechanism behind heterogeneity and aggressiveness of solid tumors
http://cancerres.aacrjournals.org/ Not exact matches
We were able to use pharmaceuticals to induce cell self - eating effects and stimulate dedifferentiation though not as effectively as 3D culture, so we need to do more work on this.
E1A is the sole oncogene capable of overcoming the stringent proliferative block connected with terminal differentiation, likely due to E1A - induced mimicry of important proliferation and dedifferentiation pathways, which are prime candidates for cancer pathways (24).
Conclusions: We thus developed an FGF2 - induced model of human β - cell dedifferentiation, identified new markers of dedifferentiation, and found evidence for increased pancreatic FGF2, FGFR1, and β - cell dedifferentiation in T2D.