Sentences with phrase «inducing genes»

He is the principal discoverer of the p21 activated protein kinase (PAK) family of cell signalling proteins and of novel virulence - inducing genes in pathogenic fungi.

Researchers in Japan have succeeded in inducing the genes involved in oil synthesis in seeds to work for longer periods of time, thereby allowing them to accumulate more seed oil.

The team also found that up to 40 percent of the symbiosis - induced genes were restricted to a single mycorrhizal species.

«For its own survival advantage, HIV induces these genes in order to survive and spread throughout the body,» Dr Nasr explained.

The researchers were studying a well - established mouse model that forms a significant number of CCMs following the injection of a drug to induce gene deletion.

«Pancreatic tumor - induced gene may prove beneficial as a drug marker.»

Research from UW Medicine and collaborators indicates that a drug - like molecule can activate innate immunity and induce genes to control infection in a range of RNA viruses, including West Nile, dengue, hepatitis C, influenza A, respiratory syncytial, Nipah, Lassa and Ebola.

By that time, the sex - inducing gene was active and the volvox began making male and female gametes instead of asexual ones, the group reports online 9 June in the Proceedings of the Royal Society, London, B.

«This is because while both cell types show hydroxyurea - induced gene expression, collision with replication occurs differentially because replication forks have progressed to different extent in these cells,» said Feng.

«Using the anti-cancer drug and a replication inhibitor, hydroxyurea, in the model organism Saccharomyces cerevisiae, we observed that double strand breaks preferentially occurred at hydroxyurea - induced genes,» said Feng.

Decreased nuclear HDAC activity results in global H3 acetylation, creating a permissive environment for cocaine - induced gene expression.

However, while the genetic factors responsible for reprogramming are well known, the mechanisms underlying the responses to induced gene expression changes are not as clear.

The scientists then engineered the virus to deliver the tumor - suppressing and - cell - death inducing gene mda - 7 / IL - 24 into the cancer cells, generating a CTV.

On the other hand, as a dimer, it directly binds to response elements in the DNA (GC - response elements), thus inducing gene transcription (transactivation).

The dynamics of nucleosome formation and positioning in promoters may, for example, help to understand why some genes are highly expressed, such as those involved in normal or malignant growth, while others, such as stress - induced genes, are only rarely expressed under normal conditions.

Whitehead Institute Member Peter Reddien and two of his former graduate students, Michael Gaviño and Danielle Wenemoser, address this longstanding question this week in the journal eLife, revealing a fascinating interplay of signals between two wound - induced genes.

Retinoic acid - induced gene - 1 (RIG - I) associates with the actin cytoskeleton via caspase activation and recruitment domain - dependent interactions.

Retinoic Acid - induced Gene - I (RIG - I) Associates with Nucleotide - binding Oligomerization Domain - 2 (NOD2) to Negatively Regulate Inflammatory Signaling.

The major outlier was a protein called androgen - induced gene 1 protein (AIG1).

Notably, several PGRPs are among the most - strongly induced genes after infection in D. melanogaster [49].

Although antimicrobial peptides are not the only functional class to be overrepresented among short, secreted proteins encoded by members of multi-gene families, the prevalence of these properties among induced genes strongly suggests the possibly that at least some of these genes encode novel immune effectors.

Finally, we show that a high proportion of these novel induced genes are taxonomically restricted, highlighting the rapid evolution of immune gene content.

This difference in proportion Metazoan is highly significant (P = 6.91 × 10 − 13, Fisher's Exact Test); induced genes are also much more likely to be wasp - specific (31.3 % induced, 16.3 % other genes, Fisher's Exact Test P = 8.85 × 10 − 7).

In this restricted set, induced genes are also more likely to be wasp - specific (26.7 % induced, 14.8 % others, Fisher's Exact Test P = 0.004).

Activation of mTORC1 induces genes involved in glycolysis, the pentose phosphate pathway, and sterol and lipid biosynthesis (52).

To understand the properties of highly induced genes encoding short proteins, we used several tools designed to characterize different protein properties.

Notably, however, the vast majority of induced genes are not recognized as immune - related by homology alone: just 12 % are in the homology - based immune set.

Excluding genes with homology evidence for immune function, 42.24 % of induced genes encode proteins with bioinformatic evidence for a signal peptide, a significantly higher fraction that the 15.95 % of non-induced and non-immune genes that encode a protein with bioinformatic evidence for a signal peptide (P = 3.4 × 10 − 15, Fisher's Exact Test).

These glycine and proline rich peptides are some of the most highly induced genes in our entire study, with hymenoptaecin - 2 induced over 50-fold and abaecin - 2 induced over 30-fold (Table S1).

Its major target genes include proapoptotic genes Bax, Puma and Noxa, cell cycle regulator p21, and the senescence - inducing gene Plasminogen activator inhibitor 1 [5].

As expected, the 497 immune genes we describe above by homology are significantly over-represented among induced genes: 5.6 % of immune genes with detectable expression are up - regulated after infection, compared to 1.2 % of non-immune genes (Fisher's Exact Test, P = 2.735 × 10 − 11).

Based on this classification of evolutionary age of each gene, induced genes are much younger than either non-regulated or repressed genes: excluding those genes without significant expression, induced genes are only 37.9 % Metazoan compared to 64.5 % Metazoan for non-regulated genes and 55.9 % Metazoan for repressed genes (Figure 4A).

The retinoic acid — induced gene G (RIG - G), also known as IFN - inducible gene 60, was originally identified in all - trans retinoic acid (ATRA)-- treated NB4 acute promyelocytic leukemia (APL) cells (1) and plays an important role in cell growth inhibition through up - regulation of p21 and p27 (2).

Our results revealed that transcript levels of temporally induced genes are highly correlated in individual cells.

Retinoic acid — induced gene G (RIG - G), a gene originally identified in all - trans retinoic acid — treated NB4 acute promyelocytic leukemia cells, is also induced by IFNα in various hematopoietic and solid tumor cells.

For example, cluster 5 of the concise «Time Series», which consists of transiently induced genes around day 3 of differentiation, similarly to Global Cluster 30, contains the same transcripts, but in addition, it also includes T - brachyury, Axin2, Mesp2, Fgf8, Wnt8a, Sp5, Sp8, Follistatin, Mix1 and Lim1.

Finally, pharmacological PPARα activation had a minimal effect on expression of cold - induced genes in murine WAT.

Azacytidine and Decitabine induce gene - specific and non-random DNA demethylation in human cancer cell lines

Biclustering of drug ‐ induced gene expression profiles resulted in modules of drugs and genes, which were enriched in both drug and gene annotations.

Graduate student André Velásquez from Greg Martin's lab shows how to do Virus - induced Gene Silencing (VIGS) in Nicotiana benthamiana and Tomato.

Dissertation: «Epigenetic Modification of Vitamin D - induced Gene Expression in Human Colorectal and Breast Cancer Cell Lines.»

Similar research has been documented with fermented and unfermented herbs used for gastrointestinal disorders, that is, more pronounced anti-inflammatory activity and minimization of LPS - induced gene expression with the fermented blend [150].

There was also a significant reduction in LPS - induced intestinal permeability and a significant rise in stool Lactobacillus species, neither of which was noted with the unfermented blend» «Similar research has been documented with fermented and unfermented herbs used for gastrointestinal disorders, that is, more pronounced anti-inflammatory activity and minimization of LPS - induced gene expression with the fermented blend [150].

Insulin - like growth factor - 1 (IGF - 1) inversely regulates atrophy - induced genes via the phosphatidylinositol 3 - kinase / Akt / mammalian target of rapamycin (PI3K / Akt / mTOR) pathway

Not exact matches

With respect to antibiotic resistance, this novelty can be induced and we can trace the novelty to particular mutations arising absent gene transfer; i.e. the genes which give rise the resistance were not present prior to the mutation, they are new sequences and not simply the activation of dormant genes.

The article notes that «the association of childhood trauma with increased in ammation is linked to stress - induced epigenetic changes in FKBP5, a gene implicated in the development of depression and anxiety» (ibid).

Volatile release stimulated by volicitin may also depend on the octadecanoid pathway, raising the possibility of cross talk between this molecule and the wound - induced expression of defense genes.

The goal of early SMA drug discovery programs has been to identify small molecules that induce the SMN gene to produce sufficient levels of protein to improve motor neuron functioning in affected patients.

When normal and gene - altered mice got the high - fat diet along with varying levels of doxycycline, to induce GLP1 release, the normal mice grew fat and mice expressing GLP1 showed less weight gain.

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.